ID   PHTD_COMTE              Reviewed;         330 AA.
AC   Q59727;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=4,5-dihydroxyphthalate decarboxylase;
DE            Short=DHP decarboxylase;
DE            EC=4.1.1.55;
GN   Name=phtD;
OS   Comamonas testosteroni (Pseudomonas testosteroni).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Comamonas.
OX   NCBI_TaxID=285;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=M4-1;
RA   Lee J., Omori T., Kodama T.;
RT   "Identification of the metabolic intermediates of phthalate by Tn5 mutants
RT   of Pseudomonas testosteroni and analysis of the 4,5-dihydroxyphthalate
RT   decarboxylase gene.";
RL   J. Ferment. Bioeng. 77:583-590(1994).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=4,5-dihydroxyphthalate + H(+) = 3,4-dihydroxybenzoate + CO2;
CC         Xref=Rhea:RHEA:24184, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:36241, ChEBI:CHEBI:58051; EC=4.1.1.55;
CC   -!- PATHWAY: Xenobiotic degradation; phthalate degradation; 3,4-
CC       dihydroxybenzoate from phthalate: step 3/3.
CC   -!- SIMILARITY: To P.putida DHP decarboxylase. {ECO:0000305}.
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DR   EMBL; D16537; BAA03974.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q59727; -.
DR   UniPathway; UPA00726; UER00730.
DR   GO; GO:0018796; F:4,5-dihydroxyphthalate decarboxylase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046239; P:phthalate catabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR015168; SsuA/THI5.
DR   Pfam; PF09084; NMT1; 1.
PE   4: Predicted;
KW   Aromatic hydrocarbons catabolism; Decarboxylase; Lyase.
FT   CHAIN           1..330
FT                   /note="4,5-dihydroxyphthalate decarboxylase"
FT                   /id="PRO_0000058411"
SQ   SEQUENCE   330 AA;  37156 MW;  6CBDD65EA6CE5A3E CRC64;
     MSKLQLSIAV GNYDRMRPLI DGDVQIDGVD PVFMLQDPEE IFFRAFRTAD YDICELSLSS
     YSVKTAAGTS PYIAVPVFPS RAFRHSSVYV RADRGINSPA DLKGKRIGVP EYQLTANVWV
     RMFLEEEYGV KASDIQWVRG GYEDPTRIEK ISLKLPEGVS LVNAPEGRTI SNLLADGEID
     GVIGPRAPSC FDRGHPQVKY LFEDPQKAAA EWYERRKLFP IMHTLGVRKT LAEQHPWLPG
     ALVKAFEHSK AVALTRLSDT SATKVTLPFI EDQLRNARRL MGQDFWSYGF AENAHVVDRF
     LARDHAEGLS SRRLQPAELF HPASLESFKI