PHX1_SCHPO
ID PHX1_SCHPO Reviewed; 942 AA.
AC Q10328;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Homeobox transcription factor phx1;
GN Name=phx1; ORFNames=SPAC32A11.03c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=16299000; DOI=10.1074/jbc.m506611200;
RA Kwon E.S., Jeong J.H., Roe J.H.;
RT "Inactivation of homocitrate synthase causes lysine auxotrophy in
RT copper/zinc-containing superoxide dismutase-deficient yeast
RT Schizosaccharomyces pombe.";
RL J. Biol. Chem. 281:1345-1351(2006).
RN [3]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Trnascription factor that regulates the expression of the
CC homocitrate synthase (HCS) lys4. {ECO:0000269|PubMed:16299000}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:16823372}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329670; CAA93700.1; -; Genomic_DNA.
DR PIR; T38649; T38649.
DR RefSeq; NP_593776.1; NM_001019205.2.
DR AlphaFoldDB; Q10328; -.
DR SMR; Q10328; -.
DR BioGRID; 278869; 8.
DR STRING; 4896.SPAC32A11.03c.1; -.
DR iPTMnet; Q10328; -.
DR SwissPalm; Q10328; -.
DR MaxQB; Q10328; -.
DR PaxDb; Q10328; -.
DR PRIDE; Q10328; -.
DR EnsemblFungi; SPAC32A11.03c.1; SPAC32A11.03c.1:pep; SPAC32A11.03c.
DR GeneID; 2542405; -.
DR KEGG; spo:SPAC32A11.03c; -.
DR PomBase; SPAC32A11.03c; phx1.
DR VEuPathDB; FungiDB:SPAC32A11.03c; -.
DR eggNOG; KOG0849; Eukaryota.
DR HOGENOM; CLU_335282_0_0_1; -.
DR InParanoid; Q10328; -.
DR PRO; PR:Q10328; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000785; C:chromatin; NAS:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; NAS:PomBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:PomBase.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:2001172; P:positive regulation of glycolytic fermentation to ethanol; IMP:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:PomBase.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..942
FT /note="Homeobox transcription factor phx1"
FT /id="PRO_0000049410"
FT DNA_BIND 164..224
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 61..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 87..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 892..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 61..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 942 AA; 103986 MW; 3E5F22A7DA73F20F CRC64;
MRSYSNPENG GQINDNINYS EKRPTMLPEN LSLSNYDMDS FLGQFPSDNN MQLPHSTYEQ
HLQGEQQNPT NPNYFPPEFD ENKVDWKQEK PKPDAPSFAD NNSFDNVNSS KLTNPSPVQP
NIVKSESEPA NSKQNEVVEA TSVEKAKENV AHESGTPESG GSTSAPKSKK QRLTADQLAY
LLREFSKDTN PPPAIREKIG RELNIPERSV TIWFQNRRAK SKLISRRQEE ERQRILREQR
ELDSLNQKVS QAFAHEVLST SPTSPYVGGI AANRQYANTL LPKPTRKTGN FYMKSGPMQS
SMEPCIAESD IPIRQSLSST YYNSLSPNAV PVSSQRKYSA SSYSAIPNAM SVSNQAFDVE
SPPSSYATPL TGIRMPQPES DLYSYPREVS PSSGGYRMFG HSKPSSYKAS GPVRPPNMAT
GHMRTSSEPT SYDSEFYYFS CTLLVIGLWK RLRASPQDLM CFYSPPKKLF AYLIQFQGIQ
YRIEYSFFVI ESIHVFRVEE PLLNELSATA SSRDKPAPNE YWLQMDIQLS VPPVFHMITS
EGQGNCTDFT EGNQASEVLL HSLMGRATSM FQMLDRVRRA SPELGSVIRL QKGLNPHQFL
DPQWANQLPR QPDSSVFDHQ GRNPPIQGLS HDTSSEYGNK SQFKRLRSTS TPARQDLAQH
LLPPKTNTEG LMHAQSVSPI TQAMKSANVL EGSSTRLNSY EPSVSSAYPH HNLALNLDNT
QFGELGTSNI SYPLSAPSDV GSLPRASNSP SRPVMHPNTQ GINTEIKDMA AQFPNSQTGG
LTPNSWSMNT NVSVPFTTQN REFGGIGSSS ISTTMNAPSQ QLSQVPFGDV SLATENSVPS
YGFEVPSEES VYAQARTNSS VSAGVAPRLF IQTPSIPLAS SAGQDSNLIE KSSSGGVYAS
QPGASGYLSH DQSGSPFEDV YSPSAGIDFQ KLRGQQFSPD MQ
