PHX2A_MOUSE
ID PHX2A_MOUSE Reviewed; 280 AA.
AC Q62066;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Paired mesoderm homeobox protein 2A;
DE AltName: Full=Aristaless homeobox protein homolog;
DE AltName: Full=PHOX2A homeodomain protein;
DE AltName: Full=Paired-like homeobox 2A;
GN Name=Phox2a; Synonyms=Arix, Phox2, Pmx2, Pmx2a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=A/J;
RX PubMed=7910552; DOI=10.1242/dev.119.3.881;
RA Valarche I., Tissier-Seta J.-P., Hirsch M.R., Martinez S., Goridis C.,
RA Brunet J.-F.;
RT "The mouse homeodomain protein Phox2 regulates Ncam promoter activity in
RT concert with Cux/CDP and is a putative determinant of neurotransmitter
RT phenotype.";
RL Development 119:881-896(1993).
CC -!- FUNCTION: May be involved in regulating the specificity of expression
CC of the catecholamine biosynthetic genes. Acts as a transcription
CC activator/factor. Could maintain the noradrenergic phenotype (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; X75014; CAA52923.1; -; mRNA.
DR CCDS; CCDS21514.1; -.
DR PIR; I48713; I48713.
DR RefSeq; NP_032913.1; NM_008887.2.
DR AlphaFoldDB; Q62066; -.
DR SMR; Q62066; -.
DR STRING; 10090.ENSMUSP00000008090; -.
DR iPTMnet; Q62066; -.
DR PhosphoSitePlus; Q62066; -.
DR MaxQB; Q62066; -.
DR PaxDb; Q62066; -.
DR PRIDE; Q62066; -.
DR ProteomicsDB; 288203; -.
DR Antibodypedia; 16943; 212 antibodies from 35 providers.
DR DNASU; 11859; -.
DR Ensembl; ENSMUST00000008090; ENSMUSP00000008090; ENSMUSG00000007946.
DR GeneID; 11859; -.
DR KEGG; mmu:11859; -.
DR UCSC; uc009ipe.2; mouse.
DR CTD; 401; -.
DR MGI; MGI:106633; Phox2a.
DR VEuPathDB; HostDB:ENSMUSG00000007946; -.
DR eggNOG; KOG0484; Eukaryota.
DR GeneTree; ENSGT00940000161147; -.
DR HOGENOM; CLU_081152_0_0_1; -.
DR InParanoid; Q62066; -.
DR OMA; GPACPGL; -.
DR OrthoDB; 1505098at2759; -.
DR PhylomeDB; Q62066; -.
DR TreeFam; TF351612; -.
DR BioGRID-ORCS; 11859; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q62066; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q62066; protein.
DR Bgee; ENSMUSG00000007946; Expressed in superior cervical ganglion and 84 other tissues.
DR Genevisible; Q62066; MM.
DR GO; GO:0000785; C:chromatin; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:MGI.
DR GO; GO:0048484; P:enteric nervous system development; IBA:GO_Central.
DR GO; GO:0021703; P:locus ceruleus development; IMP:MGI.
DR GO; GO:0030901; P:midbrain development; IMP:MGI.
DR GO; GO:0003357; P:noradrenergic neuron differentiation; IMP:MGI.
DR GO; GO:0021623; P:oculomotor nerve formation; IMP:BHF-UCL.
DR GO; GO:0048486; P:parasympathetic nervous system development; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0043576; P:regulation of respiratory gaseous exchange; IMP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
DR GO; GO:0021523; P:somatic motor neuron differentiation; IMP:MGI.
DR GO; GO:0048485; P:sympathetic nervous system development; IMP:MGI.
DR GO; GO:0021642; P:trochlear nerve formation; IMP:BHF-UCL.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..280
FT /note="Paired mesoderm homeobox protein 2A"
FT /id="PRO_0000049260"
FT DNA_BIND 90..149
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 145..244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..205
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 280 AA; 29417 MW; F7CBFBCE66B57A5D CRC64;
MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP ALGSSNCALG
ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA QLKELERVFA ETHYPDIYTR
EELALKIDLT EARVQVWFQN RRAKFRKQER AASAKGAAGA TGAKKGEARC SSEDDDSKES
TCSPTPDSTA SLPPPPAPSL ASPRLSPSPL PAALGSGPGP QPLKGALWAG VAGGGGGGPG
TGAAELLKAW QPAEPGPGPF SGVLSSFHRK PGPALKTNLF
