ID   PHX2A_RAT               Reviewed;         281 AA.
AC   Q62782;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 136.
DE   RecName: Full=Paired mesoderm homeobox protein 2A;
DE   AltName: Full=ARIX1 homeodomain protein;
DE   AltName: Full=Aristaless homeobox protein homolog;
DE   AltName: Full=Paired-like homeobox 2A;
GN   Name=Phox2a; Synonyms=Arix, Pmx2a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8613746; DOI=10.1523/jneurosci.15-12-08109.1995;
RA   Zellmer E., Zhang Z., Greco D., Rhodes J., Cassel S., Lewis E.J.;
RT   "A homeodomain protein selectively expressed in noradrenergic tissue
RT   regulates transcription of neurotransmitter biosynthetic genes.";
RL   J. Neurosci. 15:8109-8120(1995).
CC   -!- FUNCTION: May be involved in regulating the specificity of expression
CC       of the catecholamine biosynthetic genes. Acts as a transcription
CC       activator/factor. Could maintain the noradrenergic phenotype.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in sympathetic superior cervical ganglia
CC       and in noradrenergic, dopamine beta-hydroxylase (DBH)-positive tissues.
CC       Not expressed in brain.
CC   -!- DEVELOPMENTAL STAGE: Expressed at E18 day in sympathetic ganglia.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR   EMBL; U25967; AAB04168.1; -; mRNA.
DR   RefSeq; NP_446321.1; NM_053869.1.
DR   AlphaFoldDB; Q62782; -.
DR   SMR; Q62782; -.
DR   STRING; 10116.ENSRNOP00000026702; -.
DR   jPOST; Q62782; -.
DR   PaxDb; Q62782; -.
DR   GeneID; 116648; -.
DR   KEGG; rno:116648; -.
DR   UCSC; RGD:621323; rat.
DR   CTD; 401; -.
DR   RGD; 621323; Phox2a.
DR   eggNOG; KOG0484; Eukaryota.
DR   InParanoid; Q62782; -.
DR   OrthoDB; 1505098at2759; -.
DR   PhylomeDB; Q62782; -.
DR   PRO; PR:Q62782; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0000785; C:chromatin; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:RGD.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; ISO:RGD.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR   GO; GO:0007568; P:aging; IEP:RGD.
DR   GO; GO:0048484; P:enteric nervous system development; IBA:GO_Central.
DR   GO; GO:0021703; P:locus ceruleus development; ISO:RGD.
DR   GO; GO:0030901; P:midbrain development; ISO:RGD.
DR   GO; GO:0003357; P:noradrenergic neuron differentiation; ISO:RGD.
DR   GO; GO:0021623; P:oculomotor nerve formation; ISO:RGD.
DR   GO; GO:0048486; P:parasympathetic nervous system development; ISO:RGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:RGD.
DR   GO; GO:0043576; P:regulation of respiratory gaseous exchange; ISO:RGD.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:RGD.
DR   GO; GO:0021523; P:somatic motor neuron differentiation; ISO:RGD.
DR   GO; GO:0048485; P:sympathetic nervous system development; ISO:RGD.
DR   GO; GO:0021642; P:trochlear nerve formation; ISO:RGD.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..281
FT                   /note="Paired mesoderm homeobox protein 2A"
FT                   /id="PRO_0000049261"
FT   DNA_BIND        90..149
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          145..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..182
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        189..206
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  29525 MW;  E6F4626DE0014B9A CRC64;
     MDYSYLNSYD SCVAAMEASA YGDFGACSQP GGFQYSPLRP AFPAAGPPCP ALGSSNCALG
     ALRDHQPAPY SAVPYKFFPE PSGLHEKRKQ RRIRTTFTSA QLKELERVFA ETHYPDIYTR
     EELALKIDLT EARVQVWFQN RRAKFRKQER AATAKGAAGA TGAKKGEARC SSEDDDSKES
     TCSHTPDSTA SLPPPPPAPS LASPLLSPSP LPAALGSGPG PQPLKGALWA GVAGGGGGGP
     GTGAAELLKA WQPAEPGPGP FSGVLSSFHR KPGPALKTNL F