PHYA1_TOBAC
ID PHYA1_TOBAC Reviewed; 1124 AA.
AC P33530;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Phytochrome A1;
GN Name=PHYA1;
OS Nicotiana tabacum (Common tobacco).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC Nicotiana.
OX NCBI_TaxID=4097;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8310074; DOI=10.1104/pp.101.4.1407;
RA Adam E., Deak M., Kay S., Chua N.H., Nagy F.;
RT "Sequence of a tobacco (Nicotiana tabacum) gene coding for type A
RT phytochrome.";
RL Plant Physiol. 101:1407-1408(1993).
CC -!- FUNCTION: Regulatory photoreceptor which exists in two forms that are
CC reversibly interconvertible by light: the Pr form that absorbs
CC maximally in the red region of the spectrum and the Pfr form that
CC absorbs maximally in the far-red region. Photoconversion of Pr to Pfr
CC induces an array of morphogenic responses, whereas reconversion of Pfr
CC to Pr cancels the induction of those responses. Pfr controls the
CC expression of a number of nuclear genes including those encoding the
CC small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B
CC binding protein, protochlorophyllide reductase, rRNA, etc. It also
CC controls the expression of its own gene(s) in a negative feedback
CC fashion.
CC -!- SUBUNIT: Homodimer.
CC -!- PTM: Contains one covalently linked phytochromobilin chromophore.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the phytochrome family. {ECO:0000305}.
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DR EMBL; X66784; CAA47284.1; -; Genomic_DNA.
DR AlphaFoldDB; P33530; -.
DR SMR; P33530; -.
DR STRING; 4097.P33530; -.
DR Proteomes; UP000084051; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0009584; P:detection of visible light; IEA:InterPro.
DR GO; GO:0017006; P:protein-tetrapyrrole linkage; IEA:InterPro.
DR GO; GO:0009585; P:red, far-red light phototransduction; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.270; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; -; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013654; PAS_2.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR016132; Phyto_chromo_attachment.
DR InterPro; IPR013516; Phyto_chromo_BS.
DR InterPro; IPR001294; Phytochrome.
DR InterPro; IPR012129; Phytochrome_A-E.
DR InterPro; IPR013515; Phytochrome_cen-reg.
DR InterPro; IPR043150; Phytochrome_PHY.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF00989; PAS; 2.
DR Pfam; PF08446; PAS_2; 1.
DR Pfam; PF00360; PHY; 1.
DR PIRSF; PIRSF000084; Phytochrome; 1.
DR PRINTS; PR01033; PHYTOCHROME.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55785; SSF55785; 3.
DR SUPFAM; SSF55874; SSF55874; 1.
DR TIGRFAMs; TIGR00229; sensory_box; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 1.
DR PROSITE; PS50112; PAS; 2.
DR PROSITE; PS00245; PHYTOCHROME_1; 1.
DR PROSITE; PS50046; PHYTOCHROME_2; 1.
PE 3: Inferred from homology;
KW Chromophore; Photoreceptor protein; Receptor; Reference proteome; Repeat;
KW Sensory transduction; Transcription; Transcription regulation.
FT CHAIN 1..1124
FT /note="Phytochrome A1"
FT /id="PRO_0000171995"
FT DOMAIN 218..401
FT /note="GAF"
FT DOMAIN 617..687
FT /note="PAS 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT DOMAIN 690..746
FT /note="PAC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00141"
FT DOMAIN 747..821
FT /note="PAS 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00140"
FT DOMAIN 901..1118
FT /note="Histidine kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 323
FT /ligand="phytochromobilin"
FT /ligand_id="ChEBI:CHEBI:189064"
FT /note="covalent, via 1 link"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1124 AA; 124297 MW; 4C2938CFE9A5F130 CRC64;
MSSSRPSQSS TTSARSKHSA RIIAQTTIDA KLHADFEESG DSFDYSSSVR VTSVAGDERK
PKSDRVTTAY LNQIQKGKFI QPFGCLLALD EKTFKVIAFS ENAPEMLTMV SHAVPSVGEL
PALGIGTDIR TIFTGPSAAA LQKALGFGEV SLLNPVLVHC KTSGKPYYAI VHRVTGSLII
DFEPVKPYEV PMTAAGALQS YKLAAKAITR LQALPSGSME RLCDTMVQEV FELTGYDRVM
TYKFHDDDHG EVVAEITKPG LDPYLGLHYP ATDIPQAARF LFMKNKVRMI CDCRAKHVKV
VQDEKLPFDL TLCGSTLRAP HYCHLQYMEN MSSIASLVMA VVVNDGDEEG ESSDSTQSQK
RKRLWGLVVC HNTTPRFVPF PLRYACEFLA QVFAIHVNKE LELESQILEK NILRTQTLLC
DMLMRVAPLG IVSQSPNIMD LVKCDGAALL YKNKIHRLGM TPSDFQLHDI VSWLSEYHTD
STGLSTDSLY DAGFPGALAL GDVVCGMAAV RISDKGWLFW YRSHTAAEVR WGGAKHEPGE
KDDGRKMHPR SSFKAFLEVV KTRSVPWKDY EMDAIHSLQL ILRNASKDAD AMDSNTNIIH
TKLNDLKIDG LQELEAVTAE MVRLIETASV PIFAVDVDGQ LNGWNTKIAE LTGLPVDEAI
GNHLLTLVED SSVDTVSKML ELALQGKEER NVEFEIKTHG PSGDSSPISL IVNACASRDV
GDSVVGVCFI AQDITGQKNI MDKFTRIEGD YRAIIQNPHP LIPPIFGTDQ FGWCSEWNSA
MTKLTGWRRD DVIDKMLLGE VFGTQAACCR LKNQEAFVNF GVVLNNAMTG QECAKISFGF
FARNGKYVEC LLCVSKRLDR EGAVTGLFCF LQLASHELQQ ALHIQRLSEQ TALKRLKVLA
YIRRQIRNPL SGIIFSRKML EGTNLGEEQK NILRTSSQCQ RQLNKILDDT DLDSIIDGYL
DLEMLEFKLH EVLVASISQI MMKSNGKNIM IVNDMVEDLL NETLYGDSPR LQQVLANFLL
VCVNSTPSGG QLSISGTLTK DRIGESVQLA LLEVRISHTG GGVPEELLSQ MFGTEAEASE
EGISLLISRK LVKLMNGEVQ YLREAGRSTF IISVELAVAT KSSC
