ID   PHYA_NOSS1              Reviewed;         765 AA.
AC   Q9LCC2;
DT   11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Cyanobacterial phytochrome A;
DE            EC=2.7.13.3;
GN   Name=aphA; OrderedLocusNames=alr3157;
OS   Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576).
OC   Bacteria; Cyanobacteria; Nostocales; Nostocaceae; Nostoc.
OX   NCBI_TaxID=103690;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Ohmori M., Kamiya A., Kasahara M.;
RT   "aphA, a phytochrome-like gene from Anabaena sp. strain PCC 7120.";
RL   Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7120 / SAG 25.82 / UTEX 2576;
RX   PubMed=11759840; DOI=10.1093/dnares/8.5.205;
RA   Kaneko T., Nakamura Y., Wolk C.P., Kuritz T., Sasamoto S., Watanabe A.,
RA   Iriguchi M., Ishikawa A., Kawashima K., Kimura T., Kishida Y., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakazaki N., Shimpo S., Sugimoto M.,
RA   Takazawa M., Yamada M., Yasuda M., Tabata S.;
RT   "Complete genomic sequence of the filamentous nitrogen-fixing
RT   cyanobacterium Anabaena sp. strain PCC 7120.";
RL   DNA Res. 8:205-213(2001).
CC   -!- FUNCTION: Photoreceptor which exists in two forms that are reversibly
CC       interconvertible by light: the R form that absorbs maximally in the red
CC       region of the spectrum and the FR form that absorbs maximally in the
CC       far-red region. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- PTM: Contains one covalently linked tetrapyrrole chromophore.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the phytochrome
CC       family. {ECO:0000305}.
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DR   EMBL; AB028873; BAA90662.1; -; Genomic_DNA.
DR   EMBL; BA000019; BAB74856.1; -; Genomic_DNA.
DR   PIR; AF2200; AF2200.
DR   RefSeq; WP_010997308.1; NZ_RSCN01000001.1.
DR   AlphaFoldDB; Q9LCC2; -.
DR   SMR; Q9LCC2; -.
DR   STRING; 103690.17132252; -.
DR   PRIDE; Q9LCC2; -.
DR   EnsemblBacteria; BAB74856; BAB74856; BAB74856.
DR   KEGG; ana:alr3157; -.
DR   eggNOG; COG4251; Bacteria.
DR   OMA; ECHRGRI; -.
DR   OrthoDB; 1635706at2; -.
DR   BRENDA; 2.7.13.3; 319.
DR   Proteomes; UP000002483; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR   GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0009584; P:detection of visible light; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00082; HisKA; 1.
DR   Gene3D; 3.30.450.270; -; 1.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 3.30.565.10; -; 1.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003594; HATPase_C.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR005467; His_kinase_dom.
DR   InterPro; IPR003661; HisK_dim/P.
DR   InterPro; IPR036097; HisK_dim/P_sf.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013654; PAS_2.
DR   InterPro; IPR016132; Phyto_chromo_attachment.
DR   InterPro; IPR001294; Phytochrome.
DR   InterPro; IPR013515; Phytochrome_cen-reg.
DR   InterPro; IPR043150; Phytochrome_PHY.
DR   Pfam; PF01590; GAF; 1.
DR   Pfam; PF02518; HATPase_c; 1.
DR   Pfam; PF00512; HisKA; 1.
DR   Pfam; PF08446; PAS_2; 1.
DR   Pfam; PF00360; PHY; 1.
DR   PRINTS; PR01033; PHYTOCHROME.
DR   SMART; SM00065; GAF; 1.
DR   SMART; SM00387; HATPase_c; 1.
DR   SMART; SM00388; HisKA; 1.
DR   SUPFAM; SSF47384; SSF47384; 1.
DR   SUPFAM; SSF55785; SSF55785; 1.
DR   SUPFAM; SSF55874; SSF55874; 1.
DR   PROSITE; PS50109; HIS_KIN; 1.
DR   PROSITE; PS50046; PHYTOCHROME_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chromophore; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Photoreceptor protein; Receptor; Reference proteome; Sensory transduction;
KW   Transcription; Transcription regulation; Transferase.
FT   CHAIN           1..765
FT                   /note="Cyanobacterial phytochrome A"
FT                   /id="PRO_0000171997"
FT   DOMAIN          152..320
FT                   /note="GAF"
FT   DOMAIN          535..748
FT                   /note="Histidine kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
FT   REGION          20..510
FT                   /note="Chromophore binding domain"
FT   BINDING         259
FT                   /ligand="a tetrapyrrole"
FT                   /ligand_id="ChEBI:CHEBI:26932"
FT                   /note="covalent, via 1 link"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         538
FT                   /note="Phosphohistidine; by autocatalysis"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00107"
SQ   SEQUENCE   765 AA;  86930 MW;  B66440F20AA37507 CRC64;
     MRIDVESQNI NVTSLKEAPI HLSGQIQPHG VLLVLEEPGL KILQVSNNTW GILGINAENI
     LQKKLEDLLD SFQIERIQSG LSSGNLEFIN PTKIWIRKKG DDYAVFDAVF HRNTEGFLIL
     ELEPAITQEN IPFLSFYHLA KASINQLQKT ANLRDFCQII VQEVRKVTDF DRVMLYKFDD
     DGHGSVIAEE KLDSLEPYLG LHYPESDIPK PARKLFISNS IRVIPNAQAQ AIQMIPALNP
     VSDRPVDLTN SILRSAANCH LEYLHNMGVG ASLTISLIKD NKLWGLIACH HLSAKYVSYE
     LRKACEFLGR VIFAEISARE ETEDYDYRMN LTHIQSLLVE YMSQEDNFVD GLIKHQPSLL
     DLTSAQGAAV CFGDHCTLIG ETPKAEDLVF LVQWLKNNVE EEVFYTDSLP QVYPDAERYK
     NVASGLLAIP ISQRNYVLWF RPEVIQTVNW GGDPNQPFEV NKLDGNVRLC PRKSFELWKE
     TVRLTSLPWR YVEIRAALEL RKAIVNIVLR QADELAQLAH DLERSNAELK KFAYVASHDL
     QEPLNQVANY VQLLEMRYQD QLDADANEFI TFAVEGVSLM QTLIDDVLAY SKVDTQAIAF
     QLTEVEKALD KALGNLRQRI AETGANITHD PLPTVMAGST QLMQLFQNLI ANAIKFRSEE
     APQIHIGAER LEDEWLFSVR DNGIGIDPQF SDRIFVIFQR LHTRDEYHGT GMGLAICKKI
     IECHRGRIWV ESQLGEGATF YFTIPVGGRE RERRNGRKTQ NNLFS