ID   PHYD1_DANRE             Reviewed;         291 AA.
AC   Q5U3U0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Phytanoyl-CoA dioxygenase domain-containing protein 1 {ECO:0000250|UniProtKB:Q5SRE7};
DE            Short=Protein PHYHD1 {ECO:0000250|UniProtKB:Q5SRE7};
DE            EC=1.14.11.- {ECO:0000250|UniProtKB:Q5SRE7};
GN   Name=phyhd1; ORFNames=zgc:101639;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: 2-oxoglutarate(2OG)-dependent dioxygenase that catalyzes the
CC       conversion of 2-oxoglutarate to succinate and CO(2) in an iron-
CC       dependent manner. However, does not couple 2OG turnover to the
CC       hydroxylation of acyl-coenzyme A derivatives, implying that it is not
CC       directly involved in phytanoyl coenzyme-A metabolism. Does not show
CC       detectable activity towards fatty acid CoA thioesters.
CC       {ECO:0000250|UniProtKB:Q5SRE7}.
CC   -!- COFACTOR:
CC       Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC         Evidence={ECO:0000250|UniProtKB:Q5SRE7};
CC   -!- SIMILARITY: Belongs to the PhyH family. PHYHD1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC085396; AAH85396.1; -; mRNA.
DR   RefSeq; NP_001007446.1; NM_001007445.1.
DR   RefSeq; XP_005161033.1; XM_005160976.3.
DR   AlphaFoldDB; Q5U3U0; -.
DR   SMR; Q5U3U0; -.
DR   STRING; 7955.ENSDARP00000123099; -.
DR   PaxDb; Q5U3U0; -.
DR   DNASU; 492804; -.
DR   Ensembl; ENSDART00000025612; ENSDARP00000015072; ENSDARG00000029905.
DR   Ensembl; ENSDART00000147187; ENSDARP00000123099; ENSDARG00000029905.
DR   GeneID; 492804; -.
DR   KEGG; dre:492804; -.
DR   CTD; 254295; -.
DR   ZFIN; ZDB-GENE-041114-159; phyhd1.
DR   eggNOG; KOG3290; Eukaryota.
DR   GeneTree; ENSGT00390000006287; -.
DR   InParanoid; Q5U3U0; -.
DR   OMA; KYSEDNW; -.
DR   OrthoDB; 1316775at2759; -.
DR   PhylomeDB; Q5U3U0; -.
DR   TreeFam; TF300011; -.
DR   PRO; PR:Q5U3U0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000029905; Expressed in liver and 27 other tissues.
DR   ExpressionAtlas; Q5U3U0; baseline and differential.
DR   GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR008775; Phytyl_CoA_dOase.
DR   Pfam; PF05721; PhyH; 1.
PE   2: Evidence at transcript level;
KW   Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome.
FT   CHAIN           1..291
FT                   /note="Phytanoyl-CoA dioxygenase domain-containing protein
FT                   1"
FT                   /id="PRO_0000313636"
FT   BINDING         102
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250|UniProtKB:O14832"
FT   BINDING         141
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250|UniProtKB:O14832"
FT   BINDING         156..158
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250|UniProtKB:O14832"
FT   BINDING         156
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:O14832"
FT   BINDING         158
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:O14832"
FT   BINDING         174
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250|UniProtKB:O14832"
FT   BINDING         246
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /evidence="ECO:0000250|UniProtKB:O14832"
FT   BINDING         248
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250|UniProtKB:O14832"
FT   BINDING         257
FT                   /ligand="2-oxoglutarate"
FT                   /ligand_id="ChEBI:CHEBI:16810"
FT                   /evidence="ECO:0000250|UniProtKB:O14832"
SQ   SEQUENCE   291 AA;  33194 MW;  A00B8B72C8E87E5F CRC64;
     MDVLTDQDVQ KFRDEGYLVL EGLLSPEECD ALRRRMSEII ESMDVPEHCR TQFSTDHDEQ
     LKTQGNADYF ITSGDKIRFF FEKGVFDDKG EFVVPKEQSL NKIGHALHAY EPLFKRVTHS
     PKVQNICKKL ELINPVILQS MYIFKQPGIG GEVTPHQDAT FLYTQPLGRV MGVWVALEDA
     MQENGCLWFI PGSHNDGITR RMVRTPKGTF PLTDFIGREK DYDDKLFVPA PVKKGGAVLI
     HGEVVHRSAA NTSDASRHVY TFHIMESENT VWSPENWLQA TEELPFPSLY T