PHYD1_DICDI
ID PHYD1_DICDI Reviewed; 281 AA.
AC Q54XH6;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Phytanoyl-CoA dioxygenase domain-containing protein 1 homolog;
DE EC=1.-.-.-;
GN Name=phyhd1; ORFNames=DDB_G0278961;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Has alpha-ketoglutarate-dependent dioxygenase activity. Does
CC not show detectable activity towards fatty acid CoA thioesters. Is not
CC expected to be active with phytanoyl CoA (By similarity).
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000250};
CC -!- SIMILARITY: Belongs to the PhyH family. PHYHD1 subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000024; EAL68082.1; -; Genomic_DNA.
DR RefSeq; XP_647827.1; XM_642735.1.
DR AlphaFoldDB; Q54XH6; -.
DR SMR; Q54XH6; -.
DR STRING; 44689.DDB0218136; -.
DR PaxDb; Q54XH6; -.
DR EnsemblProtists; EAL68082; EAL68082; DDB_G0278961.
DR GeneID; 8621787; -.
DR KEGG; ddi:DDB_G0278961; -.
DR dictyBase; DDB_G0278961; -.
DR eggNOG; KOG3290; Eukaryota.
DR HOGENOM; CLU_048953_0_0_1; -.
DR InParanoid; Q54XH6; -.
DR OMA; KYSEDNW; -.
DR PhylomeDB; Q54XH6; -.
DR PRO; PR:Q54XH6; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR008775; Phytyl_CoA_dOase.
DR Pfam; PF05721; PhyH; 1.
PE 3: Inferred from homology;
KW Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome.
FT CHAIN 1..281
FT /note="Phytanoyl-CoA dioxygenase domain-containing protein
FT 1 homolog"
FT /id="PRO_0000331232"
FT BINDING 95
FT /ligand="2-oxoglutarate"
FT /ligand_id="ChEBI:CHEBI:16810"
FT /evidence="ECO:0000250"
FT BINDING 134
FT /ligand="2-oxoglutarate"
FT /ligand_id="ChEBI:CHEBI:16810"
FT /evidence="ECO:0000250"
FT BINDING 149..151
FT /ligand="2-oxoglutarate"
FT /ligand_id="ChEBI:CHEBI:16810"
FT /evidence="ECO:0000250"
FT BINDING 149
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 151
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 166
FT /ligand="2-oxoglutarate"
FT /ligand_id="ChEBI:CHEBI:16810"
FT /evidence="ECO:0000250"
FT BINDING 239
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000250"
FT BINDING 241
FT /ligand="2-oxoglutarate"
FT /ligand_id="ChEBI:CHEBI:16810"
FT /evidence="ECO:0000250"
FT BINDING 250
FT /ligand="2-oxoglutarate"
FT /ligand_id="ChEBI:CHEBI:16810"
FT /evidence="ECO:0000250"
SQ SEQUENCE 281 AA; 32042 MW; EB5D2EB6397FB1C4 CRC64;
MKLTEEQVAQ YKKDGFLIIR NFNTTEEIDI VRGEMKKLID ELDTPSTISI FTTSEQERKV
DDYFLGSGDK IRYFFEKGSI EDGKLIVPKD MAFNKVGHAL HDLNPKFEEF SYSQKIHDLI
YSLGIYNKAL SGIMYIFKNQ KIGGEVDIHQ DSTFLHTTPL TTHAIWFAFE DSTIENGCLR
GLPGSHTEGI TRRFITDPNS ESGCSFIKLA EDKQYNKSDF VALECKKGDI ILLDGSVVHY
SEPNTSPNSR HAYTLHFIEG DNGVIYENDN WLQSAKPFRV L
