ID   PHYIP_RAT               Reviewed;         330 AA.
AC   Q568Z9;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Phytanoyl-CoA hydroxylase-interacting protein;
DE   AltName: Full=Phytanoyl-CoA hydroxylase-associated protein 1;
DE            Short=PAHX-AP1;
DE            Short=PAHXAP1;
GN   Name=Phyhip;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Its interaction with PHYH suggests a role in the development
CC       of the central system. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PHYH and ADGRB1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PHYHIP family. {ECO:0000305}.
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DR   EMBL; BC092627; AAH92627.1; -; mRNA.
DR   RefSeq; NP_001017376.1; NM_001017376.1.
DR   RefSeq; XP_017455395.1; XM_017599906.1.
DR   RefSeq; XP_017460418.1; XM_017604929.1.
DR   AlphaFoldDB; Q568Z9; -.
DR   BioGRID; 253176; 4.
DR   IntAct; Q568Z9; 1.
DR   STRING; 10116.ENSRNOP00000014441; -.
DR   GlyGen; Q568Z9; 2 sites.
DR   iPTMnet; Q568Z9; -.
DR   PhosphoSitePlus; Q568Z9; -.
DR   jPOST; Q568Z9; -.
DR   PaxDb; Q568Z9; -.
DR   PRIDE; Q568Z9; -.
DR   Ensembl; ENSRNOT00000014441; ENSRNOP00000014441; ENSRNOG00000010555.
DR   GeneID; 290356; -.
DR   KEGG; rno:290356; -.
DR   UCSC; RGD:1305790; rat.
DR   CTD; 9796; -.
DR   RGD; 1305790; Phyhip.
DR   eggNOG; ENOG502QQIT; Eukaryota.
DR   GeneTree; ENSGT00390000014563; -.
DR   HOGENOM; CLU_054218_1_0_1; -.
DR   InParanoid; Q568Z9; -.
DR   OMA; FQHVRMH; -.
DR   OrthoDB; 659430at2759; -.
DR   PhylomeDB; Q568Z9; -.
DR   TreeFam; TF314485; -.
DR   PRO; PR:Q568Z9; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000010555; Expressed in frontal cortex and 10 other tissues.
DR   Genevisible; Q568Z9; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:1990782; F:protein tyrosine kinase binding; ISO:RGD.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR042868; PHYHIP/PHYHIPL.
DR   InterPro; IPR045545; PHYIP/PHIPL_C.
DR   PANTHER; PTHR15698; PTHR15698; 1.
DR   Pfam; PF19281; PHYHIP_C; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   PROSITE; PS50853; FN3; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Reference proteome.
FT   CHAIN           1..330
FT                   /note="Phytanoyl-CoA hydroxylase-interacting protein"
FT                   /id="PRO_0000285814"
FT   DOMAIN          6..115
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT   CARBOHYD        14
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        325
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   330 AA;  37555 MW;  C87196F5D6BDA7AD CRC64;
     MELLSTPHSI EINNITCDSF RISWAMEDSD LERVTHYFID LNKKENKNSN KFKHRDVPTK
     LVAKAVPLPM TVRGHWFLSP RTEYSVAVQT AVKQSDGEYL VSGWSETVEF CTGDYAKEHL
     AQLQEKAEQI AGRMLRFSVF YRNHHKEYFQ HARTHCGNVL QPYLKDNSGS HGSPTSGMLH
     GVFFSCNTEF NTGQPPQDSP YGRWRFQIPA QRLFNPSTNL YFADFYCMYT AYHYAILVLA
     PKGSLGDRFC RDRLPLLDIA CNKFLTCSVE DGELIFRHAQ DLILEIIYTE PVDLSLGTLG
     EISGHQLMSL STADAKKDPS CKTCNISVGR