PHZB1_PSEAE
ID PHZB1_PSEAE Reviewed; 162 AA.
AC O69753; Q7DC83;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Phenazine biosynthesis protein PhzB1 {ECO:0000303|PubMed:11591691};
GN Name=phzB1 {ECO:0000303|PubMed:11591691}; OrderedLocusNames=PA4211;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND PATHWAY.
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=11591691; DOI=10.1128/jb.183.21.6454-6465.2001;
RA Mavrodi D.V., Bonsall R.F., Delaney S.M., Soule M.J., Phillips G.,
RA Thomashow L.S.;
RT "Functional analysis of genes for biosynthesis of pyocyanin and phenazine-
RT 1-carboxamide from Pseudomonas aeruginosa PAO1.";
RL J. Bacteriol. 183:6454-6465(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
RN [3]
RP INDUCTION.
RX PubMed=11544214; DOI=10.1128/jb.183.19.5529-5534.2001;
RA Whiteley M., Greenberg E.P.;
RT "Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-
RT controlled genes.";
RL J. Bacteriol. 183:5529-5534(2001).
RN [4]
RP FUNCTION, AND INDUCTION.
RX PubMed=23129634; DOI=10.1073/pnas.1213901109;
RA Recinos D.A., Sekedat M.D., Hernandez A., Cohen T.S., Sakhtah H.,
RA Prince A.S., Price-Whelan A., Dietrich L.E.;
RT "Redundant phenazine operons in Pseudomonas aeruginosa exhibit environment-
RT dependent expression and differential roles in pathogenicity.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:19420-19425(2012).
CC -!- FUNCTION: Involved in the biosynthesis of the antibiotic phenazine, a
CC nitrogen-containing heterocyclic molecule. PhzB1 (operon
CC phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during
CC planktonic growth. {ECO:0000269|PubMed:23129634,
CC ECO:0000305|PubMed:11591691}.
CC -!- PATHWAY: Antibiotic biosynthesis; phenazine biosynthesis.
CC {ECO:0000305|PubMed:11591691}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9S508}.
CC -!- INDUCTION: Under control of LasR (PubMed:11544214). In liquid cultures
CC (aerobic), phz1 operon is induced by quinolone signal via 2-heptyl-3-
CC hydroxy-4-quinolone (PQS) (PubMed:23129634). In biofilm (microaerobic),
CC phz1 operon is not induced by PQS, because the biosynthesis of PQS by
CC the monooxygenase PqsH requires molecular oxygen (PubMed:23129634).
CC {ECO:0000269|PubMed:11544214, ECO:0000269|PubMed:23129634}.
CC -!- SIMILARITY: Belongs to the PhzA/PhzB family. {ECO:0000305}.
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DR EMBL; AF005404; AAC64490.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG07598.1; -; Genomic_DNA.
DR PIR; F83118; F83118.
DR RefSeq; NP_252900.1; NC_002516.2.
DR RefSeq; WP_003114730.1; NZ_QZGD01000024.1.
DR AlphaFoldDB; O69753; -.
DR STRING; 287.DR97_3700; -.
DR PaxDb; O69753; -.
DR PRIDE; O69753; -.
DR DNASU; 880518; -.
DR EnsemblBacteria; AAG07598; AAG07598; PA4211.
DR GeneID; 880518; -.
DR KEGG; pae:PA4211; -.
DR PATRIC; fig|208964.12.peg.4412; -.
DR PseudoCAP; PA4211; -.
DR HOGENOM; CLU_141345_0_0_6; -.
DR OMA; QREFMNP; -.
DR PhylomeDB; O69753; -.
DR BioCyc; PAER208964:G1FZ6-4284-MON; -.
DR UniPathway; UPA00099; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0002047; P:phenazine biosynthetic process; IDA:PseudoCAP.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR004964; PhzA_PhzB.
DR Pfam; PF03284; PHZA_PHZB; 1.
DR SUPFAM; SSF54427; SSF54427; 1.
PE 2: Evidence at transcript level;
KW Antibiotic biosynthesis; Reference proteome.
FT CHAIN 1..162
FT /note="Phenazine biosynthesis protein PhzB1"
FT /id="PRO_0000287800"
SQ SEQUENCE 162 AA; 18888 MW; F641EECE73F0B78F CRC64;
MPDTTNPIGF TDANELREKN RATVEKYMNT KGQDRLRRHE LFVEDGCGGL WTTDTGSPIV
IRGKDKLAEH AVWSLKCFPD WEWYNINIFG TDDPNHFWVE CDGHGKILFP GYPEGYYENH
FLHSFELEDG KIKRNREFMN VFQQLRALSI PVPQIKREGI PT