ID   PHZC_PSECL              Reviewed;         400 AA.
AC   Q51517;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Probable phospho-2-dehydro-3-deoxyheptonate aldolase;
DE            EC=2.5.1.54;
DE   AltName: Full=3-deoxy-D-arabino-heptulosonate 7-phosphate synthase;
DE   AltName: Full=DAHP synthase;
DE   AltName: Full=Phospho-2-keto-3-deoxyheptonate aldolase;
GN   Name=phzC; Synonyms=phzF;
OS   Pseudomonas chlororaphis (Pseudomonas aureofaciens).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=30-84;
RX   PubMed=8586283; DOI=10.1111/j.1574-6968.1995.tb07954.x;
RA   Pierson L.S. III, Gaffney T., Lam S., Gong F.;
RT   "Molecular analysis of genes encoding phenazine biosynthesis in the
RT   biological control bacterium. Pseudomonas aureofaciens 30-84.";
RL   FEMS Microbiol. Lett. 134:299-307(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC   -!- PATHWAY: Antibiotic biosynthesis; phenazine biosynthesis.
CC   -!- SIMILARITY: Belongs to the class-II DAHP synthase family.
CC       {ECO:0000305}.
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DR   EMBL; L48339; AAB00328.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q51517; -.
DR   SMR; Q51517; -.
DR   UniPathway; UPA00099; -.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:InterPro.
DR   GO; GO:0002047; P:phenazine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002480; DAHP_synth_2.
DR   PANTHER; PTHR21337; PTHR21337; 2.
DR   Pfam; PF01474; DAHP_synth_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Transferase; Virulence.
FT   CHAIN           1..400
FT                   /note="Probable phospho-2-dehydro-3-deoxyheptonate
FT                   aldolase"
FT                   /id="PRO_0000140857"
SQ   SEQUENCE   400 AA;  43942 MW;  426EC6FF4F399769 CRC64;
     MEDLLKRVLS CEAFQQPQWS EPSQLHDAQA YLRDSASLIR VEDILVLRAT LARVAAGEAM
     VIQSGDCAED MDESTPDHVA RKAAVLDILA GTFRLVTQQP VVRVGRIAGQ FAKPRSNNNE
     RIGDVELPVY RGDMVNGREA VCGHRQHDAQ RLVRGYSAAR DIMQHLGWKA SASQEQLSGS
     PAWTNHEMLV LDYELPQLRQ DEQGRVFLGS THWPWIGERT RQLTGAHVTL LSEVLNPVAC
     KVGPDITQDQ LLSLCERLDA KREPGRLTLI ARMGAQKVAE RLPPLVEAVR QAGHKIIWLS
     DPMHGNTIVA PCGNKTRMVQ AITEEIAAFK HAVTSAGGVA AGLHLETTPD DVSECASDAA
     GLHQVASRYK SLCDPRLNPW QAITAVMAWK NQPSSTLASF