ID   PHZC_PSEFL              Reviewed;         400 AA.
AC   Q51789;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Probable phospho-2-dehydro-3-deoxyheptonate aldolase;
DE            EC=2.5.1.54;
DE   AltName: Full=3-deoxy-D-arabino-heptulosonate 7-phosphate synthase;
DE   AltName: Full=DAHP synthase;
DE   AltName: Full=Phospho-2-keto-3-deoxyheptonate aldolase;
GN   Name=phzC;
OS   Pseudomonas fluorescens.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=294;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NRRL B-15132 / 2-79;
RX   PubMed=9573209; DOI=10.1128/jb.180.9.2541-2548.1998;
RA   Mavrodi D.V., Ksenzenko V.N., Bonsall R.F., Cook R.J., Boronin A.M.,
RA   Thomashow L.S.;
RT   "A seven-gene locus for synthesis of phenazine-1-carboxylic acid by
RT   Pseudomonas fluorescens 2-79.";
RL   J. Bacteriol. 180:2541-2548(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC   -!- PATHWAY: Antibiotic biosynthesis; phenazine biosynthesis.
CC   -!- SIMILARITY: Belongs to the class-II DAHP synthase family.
CC       {ECO:0000305}.
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DR   EMBL; L48616; AAC18902.1; -; Genomic_DNA.
DR   RefSeq; WP_043050172.1; NZ_JXCQ01000041.1.
DR   AlphaFoldDB; Q51789; -.
DR   SMR; Q51789; -.
DR   UniPathway; UPA00099; -.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:InterPro.
DR   GO; GO:0002047; P:phenazine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR002480; DAHP_synth_2.
DR   PANTHER; PTHR21337; PTHR21337; 2.
DR   Pfam; PF01474; DAHP_synth_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Transferase; Virulence.
FT   CHAIN           1..400
FT                   /note="Probable phospho-2-dehydro-3-deoxyheptonate
FT                   aldolase"
FT                   /id="PRO_0000140858"
SQ   SEQUENCE   400 AA;  44005 MW;  2787F91861253BA8 CRC64;
     MEDLLKRVLK CEALQQPQWS EPSQLHDAQA YLRDSASLIR VEDILVLRAT LARVAAGEAM
     IIQCGDCAED MDESAADHVT RKAALLDMLA GTFRLVTQQP VVRVGRIAGQ FAKPRSNHSE
     RIGDVELPVY RGDMVNGRDA VLGHRQHDAQ RLVRGYRAAQ DIMQHLGWKE PSGQEQLTGS
     PAWTSHEMLV LDYELPQVRR DEQGRTFLGS THWPWIGERT RQLTGAHVAL LSEVLNPVAC
     KVGPDITQDQ LLSLCERLDP RREPGRLTLI ARMGAHKVAD RLPPLVEAVR RAGHKIIWLS
     DPMHGNTIVA PCGNKTRMVQ TITDEITAFK HAVVSAGGVA GGLHLETTPD DVSECASDAA
     GLGQVGSHYK SLCDPRLNPW QAITAVMAWK ACPPPSFVSL