ID   PHZI_PSEFL              Reviewed;         196 AA.
AC   Q51785;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Acyl-homoserine-lactone synthase;
DE            EC=2.3.1.184;
DE   AltName: Full=Autoinducer synthesis protein PhzI;
GN   Name=phzI;
OS   Pseudomonas fluorescens.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=294;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NRRL B-15132 / 2-79;
RX   PubMed=9573209; DOI=10.1128/jb.180.9.2541-2548.1998;
RA   Mavrodi D.V., Ksenzenko V.N., Bonsall R.F., Cook R.J., Boronin A.M.,
RA   Thomashow L.S.;
RT   "A seven-gene locus for synthesis of phenazine-1-carboxylic acid by
RT   Pseudomonas fluorescens 2-79.";
RL   J. Bacteriol. 180:2541-2548(1998).
CC   -!- FUNCTION: Required for the synthesis of a yet unknown N-aceyl-
CC       homoserine lactone (N-aceyl-HSL), an autoinducer molecule which binds
CC       to PhzR and thus regulates phenazine production.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-
CC         homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine;
CC         Xref=Rhea:RHEA:10096, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:14125,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:55474,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651;
CC         EC=2.3.1.184;
CC   -!- SIMILARITY: Belongs to the autoinducer synthase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00533}.
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DR   EMBL; L48616; AAC18898.1; -; Genomic_DNA.
DR   RefSeq; WP_043050169.1; NZ_JXCQ01000041.1.
DR   AlphaFoldDB; Q51785; -.
DR   SMR; Q51785; -.
DR   GO; GO:0061579; F:N-acyl homoserine lactone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR018311; Autoind_synth_CS.
DR   InterPro; IPR001690; Autoind_synthase.
DR   PANTHER; PTHR39322; PTHR39322; 1.
DR   Pfam; PF00765; Autoind_synth; 1.
DR   PRINTS; PR01549; AUTOINDCRSYN.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS00949; AUTOINDUCER_SYNTH_1; 1.
DR   PROSITE; PS51187; AUTOINDUCER_SYNTH_2; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Autoinducer synthesis; Quorum sensing;
KW   S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..196
FT                   /note="Acyl-homoserine-lactone synthase"
FT                   /id="PRO_0000210891"
SQ   SEQUENCE   196 AA;  22400 MW;  24122CDAF4A6E461 CRC64;
     MHMEEHALSA MDDELKLMLG RFRHEQFVEK LGWRLPIPPH QAGYEWDQYD TEHARYLLAF
     NEHRSIVGCA RLIPTTFPNL LEGVFSHACA GAPPRHPAIW EMTRFTTREP QLAMPLFWKT
     LKTASLAGAD AIVGIVNSTM ERYYKINGVK YERLGSVIDH QNEKILAIKL SAHREHHRGA
     RLPSGFTSEA LLEETA