ID   PI15A_DANRE             Reviewed;         260 AA.
AC   Q7T141;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Peptidase inhibitor 15-A;
DE   Flags: Precursor;
GN   Name=pi15a; Synonyms=pi15; ORFNames=si:rp71-1m12.1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- FUNCTION: Serine protease inhibitor which displays weak inhibitory
CC       activity against trypsin (By similarity). May play a role in facial
CC       patterning during embryonic development (By similarity).
CC       {ECO:0000250|UniProtKB:O43692, ECO:0000250|UniProtKB:Q98ST6}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O43692}.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAE17614.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AL627168; CAE17614.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; NP_001153449.1; NM_001159977.1.
DR   AlphaFoldDB; Q7T141; -.
DR   SMR; Q7T141; -.
DR   STRING; 7955.ENSDARP00000117953; -.
DR   PaxDb; Q7T141; -.
DR   Ensembl; ENSDART00000141620; ENSDARP00000117953; ENSDARG00000045378.
DR   GeneID; 561978; -.
DR   KEGG; dre:561978; -.
DR   CTD; 561978; -.
DR   ZFIN; ZDB-GENE-040724-135; pi15a.
DR   eggNOG; KOG3017; Eukaryota.
DR   GeneTree; ENSGT00940000158635; -.
DR   HOGENOM; CLU_035730_2_2_1; -.
DR   InParanoid; Q7T141; -.
DR   OMA; CSPNEVY; -.
DR   OrthoDB; 1528782at2759; -.
DR   PhylomeDB; Q7T141; -.
DR   TreeFam; TF316148; -.
DR   PRO; PR:Q7T141; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 24.
DR   Bgee; ENSDARG00000045378; Expressed in swim bladder and 11 other tissues.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0030414; F:peptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0010466; P:negative regulation of peptidase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Glycoprotein; Protease inhibitor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..62
FT                   /evidence="ECO:0000250|UniProtKB:O43692"
FT                   /id="PRO_0000287628"
FT   CHAIN           63..260
FT                   /note="Peptidase inhibitor 15-A"
FT                   /id="PRO_0000287629"
FT   DOMAIN          73..213
FT                   /note="SCP"
FT   CARBOHYD        37
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        126
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   260 AA;  29345 MW;  E664A54E35DA747D CRC64;
     MNENRLAIDI LLLCISCGAS ALAGFSPTAS SSLPATNLTD IGFAPPKYLT EAANIPKTRR
     KRYISQNDML AILDYHNKVR GKVFPPASNM EYMVWDDTLA KTAEQWASTC IWEHGPRNLL
     RFLGQNLSVR TGRYRSILQL VKPWHDEVKD YSFPYPRDCN PRCPLKCYGP MCTHYTQMVW
     ATSNKVGCAI NTCHNMNVWG SVWKRATYLV CNYSPKGNWI GEAPYKVGVP CSMCPPSYGG
     SCSNNMCFPA VNSNYLHWFK