PI21_ORYSI
ID PI21_ORYSI Reviewed; 263 AA.
AC A2XT03; B5UA06; Q01LA1;
DT 05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Protein PYRICULARIA ORYZAE RESISTANCE 21 {ECO:0000303|PubMed:19696351};
DE Short=Pi21 {ECO:0000303|PubMed:19696351};
GN Name=PI21 {ECO:0000303|PubMed:19696351};
GN ORFNames=OsI_15741 {ECO:0000312|EMBL:EAY93963.1},
GN OSIGBa0113L04.7 {ECO:0000312|EMBL:CAH66470.1},
GN OSIGBa0155K12.2 {ECO:0000312|EMBL:CAH66399.1};
OS Oryza sativa subsp. indica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39946;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=cv. Kasalath;
RX PubMed=19696351; DOI=10.1126/science.1175550;
RA Fukuoka S., Saka N., Koga H., Ono K., Shimizu T., Ebana K., Hayashi N.,
RA Takahashi A., Hirochika H., Okuno K., Yano M.;
RT "Loss of function of a proline-containing protein confers durable disease
RT resistance in rice.";
RL Science 325:998-1001(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Guang-Lu-Ai No.4;
RX PubMed=12447439; DOI=10.1038/nature01183;
RA Feng Q., Zhang Y., Hao P., Wang S., Fu G., Huang Y., Li Y., Zhu J., Liu Y.,
RA Hu X., Jia P., Zhang Y., Zhao Q., Ying K., Yu S., Tang Y., Weng Q.,
RA Zhang L., Lu Y., Mu J., Lu Y., Zhang L.S., Yu Z., Fan D., Liu X., Lu T.,
RA Li C., Wu Y., Sun T., Lei H., Li T., Hu H., Guan J., Wu M., Zhang R.,
RA Zhou B., Chen Z., Chen L., Jin Z., Wang R., Yin H., Cai Z., Ren S., Lv G.,
RA Gu W., Zhu G., Tu Y., Jia J., Zhang Y., Chen J., Kang H., Chen X., Shao C.,
RA Sun Y., Hu Q., Zhang X., Zhang W., Wang L., Ding C., Sheng H., Gu J.,
RA Chen S., Ni L., Zhu F., Chen W., Lan L., Lai Y., Cheng Z., Gu M., Jiang J.,
RA Li J., Hong G., Xue Y., Han B.;
RT "Sequence and analysis of rice chromosome 4.";
RL Nature 420:316-320(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. 93-11;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [4]
RP REVIEW.
RX PubMed=18533827; DOI=10.1094/mpmi-21-7-0859;
RA Ballini E., Morel J.-B., Droc G., Price A., Courtois B., Notteghem J.-L.,
RA Tharreau D.;
RT "A genome-wide meta-analysis of rice blast resistance genes and
RT quantitative trait loci provides new insights into partial and complete
RT resistance.";
RL Mol. Plant Microbe Interact. 21:859-868(2008).
RN [5]
RP REVIEW.
RX PubMed=23184051; DOI=10.1007/s11033-012-2318-0;
RA Miah G., Rafii M.Y., Ismail M.R., Puteh A.B., Rahim H.A., Asfaliza R.,
RA Latif M.A.;
RT "Blast resistance in rice: a review of conventional breeding to molecular
RT approaches.";
RL Mol. Biol. Rep. 40:2369-2388(2013).
CC -!- FUNCTION: Involved in defense responses. Contributes to slowing defense
CC responses toward Magnaporthe oryzae. {ECO:0000269|PubMed:19696351}.
CC -!- DISRUPTION PHENOTYPE: The pi21 allele confers an improved non-race-
CC specific blast resistance toward Magnaporthe oryzae.
CC {ECO:0000269|PubMed:19696351}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAH66399.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAH66470.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB430854; BAG72124.1; -; Genomic_DNA.
DR EMBL; CR855095; CAH66399.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CR855104; CAH66470.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CM000129; EAY93963.1; -; Genomic_DNA.
DR AlphaFoldDB; A2XT03; -.
DR SMR; A2XT03; -.
DR STRING; 39946.A2XT03; -.
DR EnsemblPlants; BGIOSGA015169-TA; BGIOSGA015169-PA; BGIOSGA015169.
DR Gramene; BGIOSGA015169-TA; BGIOSGA015169-PA; BGIOSGA015169.
DR HOGENOM; CLU_060839_1_0_1; -.
DR OMA; SGGHGNC; -.
DR Proteomes; UP000007015; Chromosome 4.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:EnsemblPlants.
DR GO; GO:1900150; P:regulation of defense response to fungus; IMP:UniProtKB.
DR InterPro; IPR044169; PI21.
DR PANTHER; PTHR47488; PTHR47488; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 4: Predicted;
KW Metal-binding; Plant defense; Reference proteome.
FT CHAIN 1..263
FT /note="Protein PYRICULARIA ORYZAE RESISTANCE 21"
FT /id="PRO_0000437420"
FT DOMAIN 1..68
FT /note="HMA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT REGION 126..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 12
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT BINDING 15
FT /ligand="a metal cation"
FT /ligand_id="ChEBI:CHEBI:25213"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00280"
FT CONFLICT 80
FT /note="L -> S (in Ref. 1; BAG72124 and 2; CAH66399/
FT CAH66470)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 263 AA; 29131 MW; 13C4A306B27AD54D CRC64;
MGILVISVDL QCCRCDAKIR KVLGCLEEEY CIEKVEYDVK NNRVIVRGKF DPEKLCKKIW
CKAGKIIKEI LIVDVWPPPL PPPCKPPPCE KPPEDCKPKP CHCCSCEKPK PKPKPCHCEK
PKPCHCEKPK PCEKPPPCKP EEPPKPPPEK PPPKPECKLV PYPYPVPYPY AGQWCCPKPE
PPKPPPEPPK EPEPPKPCGC SHAFVCVCKP APPPPPPCGC SGGHGNCGCG IRPWPPQVWP
PPPVCPPPPW CYTEDNANAC SIM
