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PI42C_PONAB
ID   PI42C_PONAB             Reviewed;         421 AA.
AC   Q5R488;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma {ECO:0000305};
DE            EC=2.7.1.149 {ECO:0000250|UniProtKB:Q8TBX8};
DE   AltName: Full=Phosphatidylinositol 5-phosphate 4-kinase type II gamma;
DE            Short=PI(5)P 4-kinase type II gamma;
DE            Short=PIP4KII-gamma;
GN   Name=PIP4K2C; Synonyms=PIP5K2C;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic
CC       activity. May be a GTP sensor, has higher GTP-dependent kinase activity
CC       than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin
CC       signaling through a catalytic-independent mechanism. They interact with
CC       PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-
CC       dependent conversion to PtdIns(3,4,5)P3.
CC       {ECO:0000250|UniProtKB:Q8TBX8}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-
CC         phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC         inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:12280,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57795,
CC         ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.149;
CC         Evidence={ECO:0000250|UniProtKB:Q8TBX8};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12281;
CC         Evidence={ECO:0000250|UniProtKB:Q8TBX8};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-
CC         phosphate) + ATP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-
CC         inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:55992,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:83423,
CC         ChEBI:CHEBI:84968, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000250|UniProtKB:Q8TBX8};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55993;
CC         Evidence={ECO:0000250|UniProtKB:Q8TBX8};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-
CC         phosphate) + GTP = 1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-
CC         inositol-4,5-bisphosphate) + GDP + H(+); Xref=Rhea:RHEA:55964,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:58189,
CC         ChEBI:CHEBI:83423, ChEBI:CHEBI:84968;
CC         Evidence={ECO:0000250|UniProtKB:Q8TBX8};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:55965;
CC         Evidence={ECO:0000250|UniProtKB:Q8TBX8};
CC   -!- SUBUNIT: Interacts with PIP5K1A; the interaction inhibits PIP5K1A
CC       kinase activity. {ECO:0000250|UniProtKB:Q8TBX8}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:O88370}. Cytoplasm
CC       {ECO:0000250|UniProtKB:O88370}.
CC   -!- PTM: Phosphorylated, phosphorylation is induced by EGF.
CC       {ECO:0000250|UniProtKB:O88370}.
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DR   EMBL; CR861368; CAH93428.1; -; mRNA.
DR   RefSeq; NP_001127008.1; NM_001133536.1.
DR   AlphaFoldDB; Q5R488; -.
DR   SMR; Q5R488; -.
DR   STRING; 9601.ENSPPYP00000005349; -.
DR   GeneID; 100174032; -.
DR   KEGG; pon:100174032; -.
DR   CTD; 79837; -.
DR   eggNOG; KOG0229; Eukaryota.
DR   InParanoid; Q5R488; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; ISS:UniProtKB.
DR   GO; GO:0016309; F:1-phosphatidylinositol-5-phosphate 4-kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:1902635; P:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0090217; P:negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity; ISS:UniProtKB.
DR   GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.800.10; -; 1.
DR   InterPro; IPR023610; PInositol-4-P-5-kinase.
DR   InterPro; IPR002498; PInositol-4-P-5-kinase_core.
DR   InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR   PANTHER; PTHR23086; PTHR23086; 1.
DR   Pfam; PF01504; PIP5K; 1.
DR   SMART; SM00330; PIPKc; 1.
DR   PROSITE; PS51455; PIPK; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; ATP-binding; Cytoplasm; Endoplasmic reticulum; Kinase;
KW   Lipid metabolism; Nucleotide-binding; Phosphoprotein; Reference proteome;
KW   Transferase.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TBX8"
FT   CHAIN           2..421
FT                   /note="Phosphatidylinositol 5-phosphate 4-kinase type-2
FT                   gamma"
FT                   /id="PRO_0000285752"
FT   DOMAIN          43..420
FT                   /note="PIPK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00781"
FT   REGION          69..75
FT                   /note="Required for interaction with PIP5K1A"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TBX8"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TBX8"
FT   MOD_RES         26
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TBX8"
FT   MOD_RES         349
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8TBX8"
SQ   SEQUENCE   421 AA;  47235 MW;  B591B3E709EA4A16 CRC64;
     MASSSVPPAT VSAATTGPGP GFGFASKTKK KHFVQQEVKV FRAADPLVGV FLWGVAHSIN
     ELSQVPPPVM LLPDDFKASS KIKVNNHLFH RENLPSHFKF KEYCPQVFRN LRDRFGIDDQ
     DYLVSLTRNP PSESEGSDGR FLICYDRTLV IKEVSSEDIA DMHSNLSNYH QYIVKCHGNT
     LLPQFLGMYR VSVDNEDSYM LVMRNMFSHR LPVHRKYDLK GSLVSREASD KEKVKELPTL
     KGMDFLNKNQ KVYIGEDEKK IFLEKLKRDV EFLVQLKIMD YSLLLGIHDI IRGSEPEEEG
     PVREDESEVD GDCSLTGPPA LVGSYGTSPE GIGGYIHSHR PLGPGEFESF IDVHAIRSAE
     GAPQKEVYFM GLIDILTQYD AKKKAAHAAK TVKHGAGAEI STVHPEQYAK RFLDFITNIF
     A
 
 
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