PI4P2_HUMAN
ID PI4P2_HUMAN Reviewed; 592 AA.
AC A4QPH2; Q6ICJ0; Q6ZT68; Q8WUK7;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2015, sequence version 3.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Putative phosphatidylinositol 4-kinase alpha-like protein P2;
GN Name=PI4KAP2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15461802; DOI=10.1186/gb-2004-5-10-r84;
RA Collins J.E., Wright C.L., Edwards C.A., Davis M.P., Grinham J.A.,
RA Cole C.G., Goward M.E., Aguado B., Mallya M., Mokrab Y., Huckle E.J.,
RA Beare D.M., Dunham I.;
RT "A genome annotation-driven approach to cloning the human ORFeome.";
RL Genome Biol. 5:R84.1-R84.11(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=B-cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=A4QPH2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A4QPH2-2; Sequence=VSP_031848, VSP_031849, VSP_031850;
CC Name=3;
CC IsoId=A4QPH2-4; Sequence=VSP_031848, VSP_057629, VSP_057630;
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI39842.2; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};
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DR EMBL; CR456378; CAG30264.1; -; mRNA.
DR EMBL; AK126860; BAC86726.1; -; mRNA.
DR EMBL; AP000557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC020225; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC139841; AAI39842.2; ALT_SEQ; mRNA.
DR AlphaFoldDB; A4QPH2; -.
DR SMR; A4QPH2; -.
DR IntAct; A4QPH2; 1.
DR ChEMBL; CHEMBL4105789; -.
DR iPTMnet; A4QPH2; -.
DR PhosphoSitePlus; A4QPH2; -.
DR BioMuta; HGNC:33577; -.
DR jPOST; A4QPH2; -.
DR MassIVE; A4QPH2; -.
DR MaxQB; A4QPH2; -.
DR PeptideAtlas; A4QPH2; -.
DR PRIDE; A4QPH2; -.
DR GeneCards; PI4KAP2; -.
DR HGNC; HGNC:33577; PI4KAP2.
DR neXtProt; NX_A4QPH2; -.
DR InParanoid; A4QPH2; -.
DR PathwayCommons; A4QPH2; -.
DR SignaLink; A4QPH2; -.
DR ChiTaRS; PI4KAP2; human.
DR Pharos; A4QPH2; Tdark.
DR PRO; PR:A4QPH2; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A4QPH2; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004430; F:1-phosphatidylinositol 4-kinase activity; IBA:GO_Central.
DR GO; GO:0052742; F:phosphatidylinositol kinase activity; IBA:GO_Central.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; -; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048; PTHR10048; 2.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 5: Uncertain;
KW Alternative splicing; Kinase; Reference proteome; Transferase.
FT CHAIN 1..592
FT /note="Putative phosphatidylinositol 4-kinase alpha-like
FT protein P2"
FT /id="PRO_0000321963"
FT DOMAIN 275..576
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT REGION 180..318
FT /note="Pleckstrin homology (PH) domain conferring
FT phosphoinositide binding specificity"
FT /evidence="ECO:0000250"
FT REGION 281..287
FT /note="G-loop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT REGION 441..449
FT /note="Catalytic loop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT REGION 460..484
FT /note="Activation loop"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00269"
FT VAR_SEQ 325..344
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_031848"
FT VAR_SEQ 422..459
FT /note="ARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHII -> VARVATGRGK
FT SCVLHPTPATHTQPLPTPCSPQSSFVKG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_031849"
FT VAR_SEQ 460..592
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_031850"
FT VAR_SEQ 516..521
FT /note="EPGPYM -> TGLAPT (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_057629"
FT VAR_SEQ 522..592
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_057630"
FT VARIANT 223
FT /note="E -> Q (in dbSNP:rs2930770)"
FT /id="VAR_039391"
FT CONFLICT 201
FT /note="G -> E (in Ref. 1; CAG30264, 2; BAC86726 and 4;
FT AAI39842/BC020225)"
FT /evidence="ECO:0000305"
FT CONFLICT 214
FT /note="V -> I (in Ref. 1; CAG30264, 2; BAC86726 and 4;
FT AAI39842/BC020225)"
FT /evidence="ECO:0000305"
FT CONFLICT 332
FT /note="M -> T (in Ref. 1; CAG30264 and 4; AAI39842)"
FT /evidence="ECO:0000305"
FT CONFLICT 423
FT /note="R -> C (in Ref. 1; CAG30264 and 4; AAI39842)"
FT /evidence="ECO:0000305"
FT CONFLICT 546
FT /note="L -> F (in Ref. 1; CAG30264 and 4; AAI39842)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 592 AA; 66944 MW; 49C0ED1C2575676D CRC64;
MTVEQKFGLF SAEIKEADPL AASEASQPKP CPPEVTPHYI WIDFLVQRFE IAKYCSSDQV
EIFSSLLQRS MSLNIGRAKG SMNRHVAAIG PRFKLLTLGL SLLHADVVPN ATIRNVLREK
IYSTAFDYFS CPPKFPTQGE KRLREDISIM IKFWTAMFSD KKYLTASQLV PPADIGDLLE
QLVEENTGSL SGPAKDFYQR GFDFFNKITN VSAVIKPYPK GDERKKACLS ALSEVTVQPG
CSLPSNPEAI VLDVDYKSGT PMQSAAKAPY LAKFKVKRCG VSELEKEGLR CRSDSEDECS
TQEADGQKIS WQAAIFKLGD DCRQKSYWGA RMPTDRILRL PASQDMLALQ IIDLFKNIFQ
LVGLDLFVFP YRVVATAPGC GVIECIPDCT SRDQLGRQTD FGMYDYFTRQ YGDESTLAFQ
QARYNFIRSM AAYSLLLFLL QIKDRHNGNI MLDKKGHIIH IDFGFMFESS PGGNLGWEPD
IKLTDEMVMI MGGKMEATPF KWFMEMCVQA TWLCGEPGPY MDVVVSLVTI MLDTGLPCFR
GQTIKLLKHR FSPNMTEREA ANFIMKVIQS CFLSNRSRTY NMIQYYQNDI PY
