ID   PI5K1_ORYSJ             Reviewed;         801 AA.
AC   Q6EX42; Q10ED0; Q70Z13;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2005, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase 1;
DE            EC=2.7.1.68;
DE   AltName: Full=1-phosphatidylinositol 4-phosphate kinase;
DE   AltName: Full=Diphosphoinositide kinase;
DE   AltName: Full=PIP5K;
DE   AltName: Full=PtdIns(4)P-5-kinase;
DE   Flags: Precursor;
GN   Name=PIPK1;
GN   OrderedLocusNames=Os03g0701800 {ECO:0000312|EMBL:BAF12919.1},
GN   LOC_Os03g49510 {ECO:0000312|EMBL:ABF98412.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [MRNA] OF
RP   112-801 (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=cv. Zhonghua 11;
RX   PubMed=15159629; DOI=10.1023/b:plan.0000028796.14336.24;
RA   Ma H., Xu S.-P., Luo D., Xu Z.-H., Xue H.-W.;
RT   "OsPIPK 1, a rice phosphatidylinositol monophosphate kinase, regulates rice
RT   heading by modifying the expression of floral induction genes.";
RL   Plant Mol. Biol. 54:295-310(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
CC   -!- FUNCTION: Involved in flowering. May suppress floral initiation by
CC       modifying the expression of genes related to floral induction.
CC       {ECO:0000269|PubMed:15159629}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-
CC         phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC         inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:14425,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58178,
CC         ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.68;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6EX42-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6EX42-2; Sequence=VSP_015135;
CC   -!- TISSUE SPECIFICITY: Expressed in young seedlings, shoot and seeds, and
CC       at lower level in roots, stem and leaf. {ECO:0000269|PubMed:15159629}.
CC   -!- INDUCTION: By auxin, abscisic acid, cytokinins, gibberellic acid,
CC       Ca(2+), methyl jasmonate and salicylic acid.
CC       {ECO:0000269|PubMed:15159629}.
CC   -!- MISCELLANEOUS: Transgenic plants suppressing PIPK1 show earlier heading
CC       (7 to 14 days earlier), delayed leaf development (a common phenotype
CC       observed with earlier flowering), and greater expression of floral
CC       induction genes.
CC   -!- MISCELLANEOUS: [Isoform 2]: May be due to intron retention.
CC       {ECO:0000305}.
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DR   EMBL; AJ439082; CAD27794.1; -; mRNA.
DR   EMBL; AJ544688; CAD67588.1; -; mRNA.
DR   EMBL; AC091670; AAX95508.1; -; Genomic_DNA.
DR   EMBL; DP000009; ABF98412.1; -; Genomic_DNA.
DR   EMBL; AP008209; BAF12919.1; -; Genomic_DNA.
DR   EMBL; AP014959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q6EX42; -.
DR   SMR; Q6EX42; -.
DR   STRING; 4530.OS03T0701800-01; -.
DR   PaxDb; Q6EX42; -.
DR   PRIDE; Q6EX42; -.
DR   EnsemblPlants; Os03t0701800-01; Os03t0701800-01; Os03g0701800. [Q6EX42-2]
DR   Gramene; Os03t0701800-01; Os03t0701800-01; Os03g0701800. [Q6EX42-2]
DR   eggNOG; KOG0229; Eukaryota.
DR   HOGENOM; CLU_971767_0_0_1; -.
DR   InParanoid; Q6EX42; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   Genevisible; Q6EX42; OS.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.800.10; -; 1.
DR   InterPro; IPR003409; MORN.
DR   InterPro; IPR017163; PIno-4-P-5_kinase_pln.
DR   InterPro; IPR023610; PInositol-4-P-5-kinase.
DR   InterPro; IPR002498; PInositol-4-P-5-kinase_core.
DR   InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR   PANTHER; PTHR23086; PTHR23086; 1.
DR   Pfam; PF02493; MORN; 8.
DR   Pfam; PF01504; PIP5K; 1.
DR   PIRSF; PIRSF037274; PIP5K_plant_prd; 1.
DR   SMART; SM00698; MORN; 8.
DR   SMART; SM00330; PIPKc; 1.
DR   PROSITE; PS51455; PIPK; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ATP-binding; Developmental protein; Differentiation;
KW   Flowering; Kinase; Nucleotide-binding; Reference proteome; Repeat; Signal;
KW   Transferase.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..801
FT                   /note="Phosphatidylinositol 4-phosphate 5-kinase 1"
FT                   /id="PRO_0000024105"
FT   REPEAT          41..63
FT                   /note="MORN 1"
FT   REPEAT          64..86
FT                   /note="MORN 2"
FT   REPEAT          87..109
FT                   /note="MORN 3"
FT   REPEAT          110..132
FT                   /note="MORN 4"
FT   REPEAT          133..155
FT                   /note="MORN 5"
FT   REPEAT          156..178
FT                   /note="MORN 6"
FT   REPEAT          182..201
FT                   /note="MORN 7"
FT   REPEAT          202..223
FT                   /note="MORN 8"
FT   DOMAIN          366..797
FT                   /note="PIPK"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00781"
FT   VAR_SEQ         494..502
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15159629"
FT                   /id="VSP_015135"
SQ   SEQUENCE   801 AA;  90680 MW;  A72DED14A54CDCE6 CRC64;
     MPGLHVVSFL VVLLLQLRSS GMHLVASELF WGNTLPNGDI YVGSFDGLVP HGPGKYMWTD
     GALYDGEWDK SKMTGRGLIQ WPSGASYEGD FRGGFIDGAG TFKGVDGSVY KGSWRMNKKH
     GMGTMVYSNS DTYEGFWNEG LPDEFGKYTW ADGNVYIGRW KSGKMNGSGV MQWINGDTLD
     CNWLNGLAHG KGYCKYASGA CYIGTWDRGL KDGHGTFYQP GSKIPCNLEV SDCLTSHDGT
     SASSSSNEKI TIGLLFLLQK LCKNWRLRRF LHRPRRISNG TTPVFDDNSG SHLCQDVSSK
     SFSADDQCLQ DSEVDKDSVY EREYVQGVLI MEQPKNEDSR MSESGIAQEN NWEKQAKGPM
     ETIYKGHRSY YLMLNLQLGI RYTVGKITPV PLREVRSNDF GPRARIKMYF PCEGSQYTPP
     HYSVDFFWKD YCPMVFRNLR EMFHIDAADY MMSICGGDSL KELSSPGKSG SIFYLSQDER
     FVIKTLRKTE LKIGLMKYVL QILLKMLPKY YNHVKAYDNT LITKFFGVHR ITLKPGRKVR
     FVVMGNMFCT ELRIHRKYDL KGSTQGRSTK KQNINENTTL KDLDLSYVFH VDKPWREALF
     RQIALDCMFL ESQSIIDYSM LLGIHFRAPN HLKRITSCQN ALESTGISAE TECSVALHHE
     ETISSKGFLL VAADEPGPAV RGSHIRGSMV RAAEGGYEEV DLVLPGTGRF RVQLGVNMPA
     RARKVQEDVN VEVENRDTIE EYDVVLYLGI IDILQEYNVS KRVEHAVKSL KFDPLSISAV
     DPNLYSRRFI SFLEKVFPEQ D