PI5K5_ARATH
ID PI5K5_ARATH Reviewed; 772 AA.
AC Q9SLG9;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase 5;
DE Short=AtPIP5K5;
DE EC=2.7.1.68;
DE AltName: Full=1-phosphatidylinositol 4-phosphate kinase 5;
DE AltName: Full=Diphosphoinositide kinase 5;
DE AltName: Full=PtdIns(4)P-5-kinase 5;
GN Name=PIP5K5; OrderedLocusNames=At2g41210; ORFNames=T3K9.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Abd El-Haliem M., Elge S., Mueller-Roeber B.;
RT "Cloning and functional analysis of a novel Arabidopsis
RT phosphatidylinositol-4-phosphate 5-kinase.";
RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12226484; DOI=10.1104/pp.004770;
RA Mueller-Roeber B., Pical C.;
RT "Inositol phospholipid metabolism in Arabidopsis. Characterized and
RT putative isoforms of inositol phospholipid kinase and phosphoinositide-
RT specific phospholipase C.";
RL Plant Physiol. 130:22-46(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-
CC phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:14425,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58178,
CC ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.68;
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DR EMBL; AF260903; AAK49397.1; -; mRNA.
DR EMBL; AC004261; AAM14925.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09944.1; -; Genomic_DNA.
DR PIR; T02098; T02098.
DR RefSeq; NP_181654.1; NM_129686.2.
DR AlphaFoldDB; Q9SLG9; -.
DR SMR; Q9SLG9; -.
DR BioGRID; 4057; 3.
DR STRING; 3702.AT2G41210.1; -.
DR iPTMnet; Q9SLG9; -.
DR PaxDb; Q9SLG9; -.
DR PRIDE; Q9SLG9; -.
DR ProteomicsDB; 236754; -.
DR EnsemblPlants; AT2G41210.1; AT2G41210.1; AT2G41210.
DR GeneID; 818720; -.
DR Gramene; AT2G41210.1; AT2G41210.1; AT2G41210.
DR KEGG; ath:AT2G41210; -.
DR Araport; AT2G41210; -.
DR TAIR; locus:2040327; AT2G41210.
DR eggNOG; KOG0229; Eukaryota.
DR HOGENOM; CLU_004312_6_4_1; -.
DR InParanoid; Q9SLG9; -.
DR OMA; IFHAERF; -.
DR OrthoDB; 259109at2759; -.
DR PhylomeDB; Q9SLG9; -.
DR BioCyc; ARA:AT2G41210-MON; -.
DR PRO; PR:Q9SLG9; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SLG9; baseline and differential.
DR Genevisible; Q9SLG9; AT.
DR GO; GO:0016324; C:apical plasma membrane; IDA:TAIR.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0090406; C:pollen tube; IDA:TAIR.
DR GO; GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046488; P:phosphatidylinositol metabolic process; IDA:TAIR.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009827; P:plant-type cell wall modification; IMP:TAIR.
DR GO; GO:0009846; P:pollen germination; IGI:TAIR.
DR GO; GO:0009860; P:pollen tube growth; IGI:TAIR.
DR Gene3D; 3.30.800.10; -; 1.
DR InterPro; IPR003409; MORN.
DR InterPro; IPR017163; PIno-4-P-5_kinase_pln.
DR InterPro; IPR023610; PInositol-4-P-5-kinase.
DR InterPro; IPR002498; PInositol-4-P-5-kinase_core.
DR InterPro; IPR027484; PInositol-4-P-5-kinase_N.
DR PANTHER; PTHR23086; PTHR23086; 1.
DR Pfam; PF02493; MORN; 8.
DR Pfam; PF01504; PIP5K; 1.
DR PIRSF; PIRSF037274; PIP5K_plant_prd; 1.
DR SMART; SM00698; MORN; 7.
DR SMART; SM00330; PIPKc; 1.
DR PROSITE; PS51455; PIPK; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Repeat;
KW Transferase.
FT CHAIN 1..772
FT /note="Phosphatidylinositol 4-phosphate 5-kinase 5"
FT /id="PRO_0000185477"
FT REPEAT 75..97
FT /note="MORN 1"
FT REPEAT 98..120
FT /note="MORN 2"
FT REPEAT 121..143
FT /note="MORN 3"
FT REPEAT 144..166
FT /note="MORN 4"
FT REPEAT 167..189
FT /note="MORN 5"
FT REPEAT 190..212
FT /note="MORN 6"
FT REPEAT 213..235
FT /note="MORN 7"
FT REPEAT 236..257
FT /note="MORN 8"
FT DOMAIN 377..768
FT /note="PIPK"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00781"
FT REGION 22..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 728..749
FT /note="Activation loop"
FT /evidence="ECO:0000250"
FT COMPBIAS 22..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 772 AA; 88204 MW; D189D4B24D517152 CRC64;
MSKDQSYVLK AWEVTVRKTQ QAKKRANSVF GTVSVAPHTD NDTTTDDNDD ETTTNRSSLE
EFYHAERVLP NGDYYTGQWY DSFPHGHGKY LWTDGCMYIG DWYNGKTMGN GKFGWPSGAT
YEGEFKSGYM DGIGTYTGPS GDAYKGQWVM NLKHGHGVKS FANGDAYDGE WRRGLQEGQG
KYQWSDGSYY IGEWKNGTIC GKGSFVWTNG NRYDGFWDEG FPRGNGTFKW DNGSFYVGHW
SKDPEEMNGT YYPSGNEGNL EWDPKDLFNN LSEYTICSGE RVPTLPSQKK LSVWNSSKRI
EKPRRTSVDG RVSVGVDRAF EKMNMWGNEI GEGGADMRKE LDAELMRLDA EGLQSLKSSP
VPMKLPKAGR KQGETISKGH RNYELMLNLQ LGIRHSVGRQ APAASLDLKP SAFDPKDKIW
RRFPREGTKY TPPHQSTEFK WKDYCPLVFR SLRKLFKVDP ADYMLSICGN DALRELSSPG
KSGSFFYLTN DDRYMIKTMK KSETKVLLGM LAAYYNHVRA FENSLVIRFF GLHCVKLNGP
TQKKVRFVIM GNLFCSKYSV HRRFDLKGSS LGRTTDKPES EIDSNTILKD LDLNFIFRLQ
KAWYQEFIRQ IDKDCEFLEQ ERIMDYSLLV GIHFREASVA GELIPSGART PIGESEEESG
PRLSRAEVDE LLSDPSRWAS IRLGTNMPAR AERTMRKNDS ELQLVGEPTG EFYEVVMIFG
IIDILQDYDI SKKLEHAYKS IQYDPSSISA VDPRQYSRRF RDFIFKVFTD DN
