ID   PIA1_PLEOS              Reviewed;          76 AA.
AC   Q7M4T6;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Serine proteinase inhibitor IA-1;
DE   AltName: Full=Proteinase A inhibitor 1;
OS   Pleurotus ostreatus (Oyster mushroom) (White-rot fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Pleurotaceae; Pleurotus.
OX   NCBI_TaxID=5322;
RN   [1]
RP   PROTEIN SEQUENCE, AND ACETYLATION AT SER-1.
RX   PubMed=7840656; DOI=10.1006/abbi.1995.1066;
RA   Dohmae N., Takio K., Tsumuraya Y., Hashimoto Y.;
RT   "The complete amino acid sequences of two serine proteinase inhibitors from
RT   the fruiting bodies of a basidiomycete, Pleurotus ostreatus.";
RL   Arch. Biochem. Biophys. 316:498-506(1995).
CC   -!- FUNCTION: Specifically inhibits an endogenous intracellular serine
CC       proteinase (proteinase A).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I9 family. {ECO:0000305}.
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DR   PIR; S69162; S69162.
DR   PDB; 1ITP; NMR; -; A=1-76.
DR   PDB; 1V5I; X-ray; 1.50 A; B=1-76.
DR   PDBsum; 1ITP; -.
DR   PDBsum; 1V5I; -.
DR   AlphaFoldDB; Q7M4T6; -.
DR   SMR; Q7M4T6; -.
DR   MEROPS; I09.002; -.
DR   iPTMnet; Q7M4T6; -.
DR   VEuPathDB; FungiDB:PLEOSDRAFT_1089399; -.
DR   EvolutionaryTrace; Q7M4T6; -.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.80; -; 1.
DR   InterPro; IPR037045; S8pro/Inhibitor_I9_sf.
PE   1: Evidence at protein level;
KW   3D-structure; Acetylation; Direct protein sequencing; Protease inhibitor;
KW   Serine protease inhibitor.
FT   CHAIN           1..76
FT                   /note="Serine proteinase inhibitor IA-1"
FT                   /id="PRO_0000212791"
FT   MOD_RES         1
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000269|PubMed:7840656"
FT   STRAND          3..9
FT                   /evidence="ECO:0007829|PDB:1V5I"
FT   STRAND          11..13
FT                   /evidence="ECO:0007829|PDB:1ITP"
FT   HELIX           15..28
FT                   /evidence="ECO:0007829|PDB:1V5I"
FT   STRAND          34..38
FT                   /evidence="ECO:0007829|PDB:1V5I"
FT   STRAND          41..48
FT                   /evidence="ECO:0007829|PDB:1V5I"
FT   HELIX           50..58
FT                   /evidence="ECO:0007829|PDB:1V5I"
FT   TURN            61..63
FT                   /evidence="ECO:0007829|PDB:1V5I"
FT   STRAND          64..69
FT                   /evidence="ECO:0007829|PDB:1V5I"
FT   STRAND          72..74
FT                   /evidence="ECO:0007829|PDB:1V5I"
SQ   SEQUENCE   76 AA;  8267 MW;  7A04289B59024441 CRC64;
     SAGKFIVIFK NDVSEDKIRE TKDEVIAEGG TITNEYNMPG MKGFAGELTP QSLTKFQGLQ
     GDLIDSIEED GIVTTQ