PIANP_HUMAN
ID PIANP_HUMAN Reviewed; 282 AA.
AC Q8IYJ0; A8K0T3; B3KPF7; B3KRI6; Q6UX35;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=PILR alpha-associated neural protein;
DE AltName: Full=PILR-associating neural protein;
DE AltName: Full=Paired immunoglobin-like type 2 receptor-associating neural protein;
DE Flags: Precursor;
GN Name=PIANP; Synonyms=C12orf53, PANP; ORFNames=UNQ828/PRO1755;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=21241660; DOI=10.1016/j.bbrc.2011.01.047;
RA Kogure A., Shiratori I., Wang J., Lanier L.L., Arase H.;
RT "PANP is a novel O-glycosylated PILRalpha ligand expressed in neural
RT tissues.";
RL Biochem. Biophys. Res. Commun. 405:428-433(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Acts as a ligand for PILRA in neural tissues, where it may be
CC involved in immune regulation. {ECO:0000269|PubMed:21241660}.
CC -!- INTERACTION:
CC Q8IYJ0; Q96FZ5: CMTM7; NbExp=3; IntAct=EBI-12204277, EBI-2807956;
CC Q8IYJ0; Q9H1M4: DEFB127; NbExp=3; IntAct=EBI-12204277, EBI-10305240;
CC Q8IYJ0; P55061: TMBIM6; NbExp=3; IntAct=EBI-12204277, EBI-1045825;
CC Q8IYJ0; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-12204277, EBI-947187;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IYJ0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IYJ0-2; Sequence=VSP_024939;
CC -!- TISSUE SPECIFICITY: Mainly expressed in adult brain and cerebellum.
CC Weaker expression in fetal brain and virtually no expression in spleen,
CC heart, kidney, liver and dorsal ganglion relative to brain.
CC {ECO:0000269|PubMed:21241660}.
CC -!- PTM: O-glycosylation at Thr-140 is essential for recognition by PILRA.
CC {ECO:0000250}.
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DR EMBL; AY358534; AAQ88898.1; -; mRNA.
DR EMBL; AK056295; BAG51669.1; -; mRNA.
DR EMBL; AK091656; BAG52398.1; -; mRNA.
DR EMBL; AK095854; BAG53145.1; -; mRNA.
DR EMBL; AK289648; BAF82337.1; -; mRNA.
DR EMBL; CH471116; EAW88750.1; -; Genomic_DNA.
DR EMBL; CH471116; EAW88751.1; -; Genomic_DNA.
DR EMBL; BC035736; AAH35736.1; -; mRNA.
DR CCDS; CCDS44818.1; -. [Q8IYJ0-1]
DR CCDS; CCDS58205.1; -. [Q8IYJ0-2]
DR RefSeq; NP_001230943.1; NM_001244014.1. [Q8IYJ0-2]
DR RefSeq; NP_001230944.1; NM_001244015.1. [Q8IYJ0-1]
DR RefSeq; NP_710152.1; NM_153685.3. [Q8IYJ0-1]
DR AlphaFoldDB; Q8IYJ0; -.
DR BioGRID; 128215; 17.
DR IntAct; Q8IYJ0; 16.
DR STRING; 9606.ENSP00000442157; -.
DR GlyGen; Q8IYJ0; 1 site.
DR PhosphoSitePlus; Q8IYJ0; -.
DR BioMuta; PIANP; -.
DR DMDM; 74728342; -.
DR MassIVE; Q8IYJ0; -.
DR PaxDb; Q8IYJ0; -.
DR PeptideAtlas; Q8IYJ0; -.
DR PRIDE; Q8IYJ0; -.
DR ProteomicsDB; 71182; -. [Q8IYJ0-1]
DR ProteomicsDB; 71183; -. [Q8IYJ0-2]
DR Antibodypedia; 22637; 107 antibodies from 16 providers.
DR DNASU; 196500; -.
DR Ensembl; ENST00000320591.9; ENSP00000317818.5; ENSG00000139200.14. [Q8IYJ0-1]
DR Ensembl; ENST00000534837.6; ENSP00000443919.1; ENSG00000139200.14. [Q8IYJ0-2]
DR Ensembl; ENST00000540656.5; ENSP00000442157.1; ENSG00000139200.14. [Q8IYJ0-1]
DR GeneID; 196500; -.
DR KEGG; hsa:196500; -.
DR MANE-Select; ENST00000534837.6; ENSP00000443919.1; NM_001244014.2; NP_001230943.1. [Q8IYJ0-2]
DR UCSC; uc001qqf.3; human. [Q8IYJ0-1]
DR CTD; 196500; -.
DR DisGeNET; 196500; -.
DR GeneCards; PIANP; -.
DR HGNC; HGNC:25338; PIANP.
DR HPA; ENSG00000139200; Tissue enriched (brain).
DR MIM; 616065; gene.
DR neXtProt; NX_Q8IYJ0; -.
DR OpenTargets; ENSG00000139200; -.
DR PharmGKB; PA143485382; -.
DR VEuPathDB; HostDB:ENSG00000139200; -.
DR eggNOG; ENOG502RH1H; Eukaryota.
DR GeneTree; ENSGT00510000049460; -.
DR HOGENOM; CLU_089346_0_0_1; -.
DR InParanoid; Q8IYJ0; -.
DR OMA; SMRDDGN; -.
DR OrthoDB; 1234686at2759; -.
DR PhylomeDB; Q8IYJ0; -.
DR TreeFam; TF336539; -.
DR PathwayCommons; Q8IYJ0; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR SignaLink; Q8IYJ0; -.
DR BioGRID-ORCS; 196500; 13 hits in 1066 CRISPR screens.
DR GenomeRNAi; 196500; -.
DR Pharos; Q8IYJ0; Tbio.
DR PRO; PR:Q8IYJ0; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8IYJ0; protein.
DR Bgee; ENSG00000139200; Expressed in cingulate cortex and 119 other tissues.
DR ExpressionAtlas; Q8IYJ0; baseline and differential.
DR Genevisible; Q8IYJ0; HS.
DR GO; GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0050776; P:regulation of immune response; IEA:InterPro.
DR InterPro; IPR029198; AJAP1_PANP_C.
DR InterPro; IPR039628; PIANP.
DR PANTHER; PTHR32023; PTHR32023; 1.
DR Pfam; PF15298; AJAP1_PANP_C; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..282
FT /note="PILR alpha-associated neural protein"
FT /id="PRO_0000285964"
FT TOPO_DOM 32..178
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 200..282
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 28..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..49
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 140
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000250"
FT VAR_SEQ 277..282
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_024939"
FT CONFLICT 22
FT /note="L -> S (in Ref. 3; BAG52398)"
FT /evidence="ECO:0000305"
FT CONFLICT 41..43
FT /note="APA -> VPT (in Ref. 3; BAG51669)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 282 AA; 30076 MW; 772F37069CE472C8 CRC64;
MESRMWPALL LSHLLPLWPL LLLPLPPPAQ GSSSSPRTPP APARPPCARG GPSAPRHVCV
WERAPPPSRS PRVPRSRRQV LPGTAPPATP SGFEEGPPSS QYPWAIVWGP TVSREDGGDP
NSANPGFLDY GFAAPHGLAT PHPNSDSMRG DGDGLILGEA PATLRPFLFG GRGEGVDPQL
YVTITISIII VLVATGIIFK FCWDRSQKRR RPSGQQGALR QEESQQPLTD LSPAGVTVLG
AFGDSPTPTP DHEEPRGGPR PGMPHPKGAP AFQLNRIPLV NL
