ID   PIANP_MACFA             Reviewed;         282 AA.
AC   Q95K74; Q9N088;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=PILR alpha-associated neural protein;
DE   AltName: Full=PILR-associating neural protein;
DE   AltName: Full=Paired immunoglobin-like type 2 receptor-associating neural protein;
DE   Flags: Precursor;
GN   Name=PIANP; Synonyms=PANP; ORFNames=QccE-10858, QtrA-14178;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RX   PubMed=11574149; DOI=10.1016/s0378-1119(01)00665-5;
RA   Osada N., Hida M., Kususda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA   Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.;
RT   "Assignment of 118 novel cDNAs of cynomolgus monkey brain to human
RT   chromosomes.";
RL   Gene 275:31-37(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a ligand for PILRA in neuronal tissues, where it may
CC       be involved in immune regulation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- PTM: O-glycosylation at Thr-140 is essential for recognition by PILRA.
CC       {ECO:0000250}.
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DR   EMBL; AB046043; BAB01625.1; -; mRNA.
DR   EMBL; AB063097; BAB60803.1; -; mRNA.
DR   RefSeq; NP_001272338.1; NM_001285409.1.
DR   RefSeq; XP_005570004.1; XM_005569947.2.
DR   AlphaFoldDB; Q95K74; -.
DR   STRING; 9541.XP_005570001.1; -.
DR   Ensembl; ENSMFAT00000022237; ENSMFAP00000003576; ENSMFAG00000001518.
DR   GeneID; 102118946; -.
DR   KEGG; mcf:102118946; -.
DR   VEuPathDB; HostDB:ENSMFAG00000001518; -.
DR   eggNOG; ENOG502RH1H; Eukaryota.
DR   GeneTree; ENSGT00510000049460; -.
DR   OMA; SMRDDGN; -.
DR   Proteomes; UP000233100; Chromosome 11.
DR   Bgee; ENSMFAG00000001518; Expressed in temporal lobe and 2 other tissues.
DR   GO; GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0050776; P:regulation of immune response; IEA:InterPro.
DR   InterPro; IPR029198; AJAP1_PANP_C.
DR   InterPro; IPR039628; PIANP.
DR   PANTHER; PTHR32023; PTHR32023; 1.
DR   Pfam; PF15298; AJAP1_PANP_C; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000255"
FT   CHAIN           32..282
FT                   /note="PILR alpha-associated neural protein"
FT                   /id="PRO_0000285965"
FT   TOPO_DOM        32..178
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        200..282
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          28..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..282
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..49
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..232
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        140
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        85
FT                   /note="A -> V (in Ref. 1; BAB01625)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   282 AA;  30076 MW;  772F37069CE472C8 CRC64;
     MESRMWPALL LSHLLPLWPL LLLPLPPPAQ GSSSSPRTPP APARPPCARG GPSAPRHVCV
     WERAPPPSRS PRVPRSRRQV LPGTAPPATP SGFEEGPPSS QYPWAIVWGP TVSREDGGDP
     NSANPGFLDY GFAAPHGLAT PHPNSDSMRG DGDGLILGEA PATLRPFLFG GRGEGVDPQL
     YVTITISIII VLVATGIIFK FCWDRSQKRR RPSGQQGALR QEESQQPLTD LSPAGVTVLG
     AFGDSPTPTP DHEEPRGGPR PGMPHPKGAP AFQLNRIPLV NL