ID   PIANP_RAT               Reviewed;         272 AA.
AC   Q5U2P6;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=PILR alpha-associated neural protein;
DE   AltName: Full=PILR-associating neural protein;
DE   AltName: Full=Paired immunoglobin-like type 2 receptor-associating neural protein;
DE   Flags: Precursor;
GN   Name=Pianp; Synonyms=Panp;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Acts as a ligand for PILRA in neuronal tissues, where it may
CC       be involved in immune regulation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- PTM: O-glycosylation at Thr-136 is essential for recognition by PILRA.
CC       {ECO:0000250}.
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DR   EMBL; BC085924; AAH85924.1; -; mRNA.
DR   RefSeq; NP_001014081.1; NM_001014059.1.
DR   AlphaFoldDB; Q5U2P6; -.
DR   STRING; 10116.ENSRNOP00000060404; -.
DR   GlyGen; Q5U2P6; 1 site.
DR   PaxDb; Q5U2P6; -.
DR   Ensembl; ENSRNOT00000065846; ENSRNOP00000060404; ENSRNOG00000017052.
DR   GeneID; 312711; -.
DR   KEGG; rno:312711; -.
DR   UCSC; RGD:1304952; rat.
DR   CTD; 196500; -.
DR   RGD; 1304952; Pianp.
DR   eggNOG; ENOG502RH1H; Eukaryota.
DR   GeneTree; ENSGT00510000049460; -.
DR   HOGENOM; CLU_089346_0_0_1; -.
DR   InParanoid; Q5U2P6; -.
DR   OrthoDB; 1234686at2759; -.
DR   PhylomeDB; Q5U2P6; -.
DR   Reactome; R-RNO-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   PRO; PR:Q5U2P6; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000017052; Expressed in frontal cortex and 18 other tissues.
DR   ExpressionAtlas; Q5U2P6; baseline and differential.
DR   Genevisible; Q5U2P6; RN.
DR   GO; GO:0016323; C:basolateral plasma membrane; IDA:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0050776; P:regulation of immune response; IEA:InterPro.
DR   InterPro; IPR029198; AJAP1_PANP_C.
DR   InterPro; IPR039628; PIANP.
DR   PANTHER; PTHR32023; PTHR32023; 1.
DR   Pfam; PF15298; AJAP1_PANP_C; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..272
FT                   /note="PILR alpha-associated neural protein"
FT                   /id="PRO_0000285967"
FT   TOPO_DOM        28..174
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        196..272
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          25..93
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          205..272
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        136
FT                   /note="O-linked (GalNAc...) threonine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   272 AA;  29132 MW;  ED34C6CBAA5A72B8 CRC64;
     MWPAQLLSQL LPLWPLLLLP LSLPAQGSSH RSPPAPARPP CVRGGPSAPR HVCVWERAPP
     PSRSPRVPRS RRQVLPGTAP PATPSGFEEG PPSSQYPWAI VWGPTVSRED GGDPNSVNPG
     FLPLDYGFAA PHGLATPHPN SDSMRDDGDG LILGETPATL RPFLFGGRGE GVDPQLYVTI
     TISIIIVLVA TGIIFKFCWD RSQKRRRPSG QQGALRQEES QQPLTDLSPA GVTVLGAFGD
     SPTPTPDHEE PRGGPRPGMP QPKGAPAFQL NR