ID   PIAP_PIG                Reviewed;         358 AA.
AC   O62640;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Putative inhibitor of apoptosis;
GN   Name=PIAP;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Aorta;
RX   PubMed=9501011; DOI=10.1006/bbrc.1998.8185;
RA   Stehlik C., de Martin R., Binder B.R., Lipp J.;
RT   "Cytokine induced expression of porcine inhibitor of apoptosis protein
RT   (iap) family member is regulated by NF-kappa B.";
RL   Biochem. Biophys. Res. Commun. 243:827-832(1998).
CC   -!- SIMILARITY: Belongs to the IAP family. {ECO:0000305}.
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DR   EMBL; U79142; AAC39171.1; -; mRNA.
DR   PIR; JC5964; JC5964.
DR   AlphaFoldDB; O62640; -.
DR   SMR; O62640; -.
DR   STRING; 9823.ENSSSCP00000020932; -.
DR   PaxDb; O62640; -.
DR   PRIDE; O62640; -.
DR   Ensembl; ENSSSCT00005017065; ENSSSCP00005010164; ENSSSCG00005011063.
DR   eggNOG; KOG1101; Eukaryota.
DR   HOGENOM; CLU_016347_1_0_1; -.
DR   InParanoid; O62640; -.
DR   TreeFam; TF105356; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   Genevisible; O62640; SS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0060546; P:negative regulation of necroptotic process; IBA:GO_Central.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0051726; P:regulation of cell cycle; IBA:GO_Central.
DR   CDD; cd00022; BIR; 2.
DR   Gene3D; 1.10.533.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001370; BIR_rpt.
DR   InterPro; IPR001315; CARD.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF00653; BIR; 2.
DR   Pfam; PF00619; CARD; 1.
DR   SMART; SM00238; BIR; 2.
DR   SMART; SM00114; CARD; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF47986; SSF47986; 1.
DR   PROSITE; PS01282; BIR_REPEAT_1; 2.
DR   PROSITE; PS50143; BIR_REPEAT_2; 2.
DR   PROSITE; PS50209; CARD; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN           1..358
FT                   /note="Putative inhibitor of apoptosis"
FT                   /id="PRO_0000122366"
FT   REPEAT          4..70
FT                   /note="BIR 1"
FT   REPEAT          90..157
FT                   /note="BIR 2"
FT   DOMAIN          193..283
FT                   /note="CARD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00046"
FT   ZN_FING         311..346
FT                   /note="RING-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   BINDING         127
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         130
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         147
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         154
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
SQ   SEQUENCE   358 AA;  40977 MW;  EB2268FA9A6190A4 CRC64;
     MNTEKDRLLT FQMWPLTFLS PADLAKAGFY YIGPGDRVAC FACGGKLSNW EPKDDAMTEH
     LRHFPNCPFL GNQLQDSSRY TVSNLSMQTY AARFKTFCNW PSSIPVHPEQ LASAGFYYMG
     HSDDVKCFCC DGGLRCWESG DDPWVEHAKW FPRCEYLIRI KGQEFISRVQ ASYPHLLEQL
     LSTSDNPEDE NAEPPNDLSL IRKNRMALFQ HLTCVLPILD SLLIARVISE QEHDVIKQKT
     QTSLQARELI DIILVKGNYA ATIFKNSLQE IDPMLYKHLF VQQDIKYIPT ENVSDLSMEE
     QLRRLQEERT CKVCMDKEVS IVFIPCGHLV VCKDCAPSLR KCPICRGTIK GTVRTFLS