PIC1_SCHPO
ID PIC1_SCHPO Reviewed; 1018 AA.
AC Q1MTN3; Q9UST0; Q9Y7L3;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Inner centromere protein-related protein pic1;
DE Short=INCENP-related protein pic1;
GN Name=pic1; ORFNames=SPBC336.15, SPBC685.01;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP INTERACTION WITH ARK1.
RX PubMed=11950927; DOI=10.1091/mbc.01-07-0330;
RA Leverson J.D., Huang H.-K., Forsburg S.L., Hunter T.;
RT "The Schizosaccharomyces pombe aurora-related kinase Ark1 interacts with
RT the inner centromere protein Pic1 and mediates chromosome segregation and
RT cytokinesis.";
RL Mol. Biol. Cell 13:1132-1143(2002).
RN [3]
RP FUNCTION, INTERACTION WITH ARK1, AND SUBCELLULAR LOCATION.
RX PubMed=16199877; DOI=10.1128/mcb.25.20.9000-9015.2005;
RA Huang H.-K., Bailis J.M., Leverson J.D., Gomez E.B., Forsburg S.L.,
RA Hunter T.;
RT "Suppressors of Bir1p (Survivin) identify roles for the chromosomal
RT passenger protein Pic1p (INCENP) and the replication initiation factor
RT Psf2p in chromosome segregation.";
RL Mol. Cell. Biol. 25:9000-9015(2005).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-171, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- FUNCTION: Required for chromosome segregation and cytokinesis. Has a
CC role in sister chromatid cohesion and condensation.
CC {ECO:0000269|PubMed:16199877}.
CC -!- SUBUNIT: Interacts with ark1. {ECO:0000269|PubMed:11950927,
CC ECO:0000269|PubMed:16199877}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, spindle.
CC Note=Associates with the elongating spindle during anaphase.
CC -!- SIMILARITY: Belongs to the INCENP family. {ECO:0000305}.
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DR EMBL; CU329671; CAB58167.1; -; Genomic_DNA.
DR PIR; T40253; T40253.
DR RefSeq; NP_596135.2; NM_001022053.2.
DR AlphaFoldDB; Q1MTN3; -.
DR BioGRID; 276782; 8.
DR DIP; DIP-59225N; -.
DR IntAct; Q1MTN3; 1.
DR STRING; 4896.SPBC336.15.1; -.
DR iPTMnet; Q1MTN3; -.
DR MaxQB; Q1MTN3; -.
DR PaxDb; Q1MTN3; -.
DR PRIDE; Q1MTN3; -.
DR EnsemblFungi; SPBC336.15.1; SPBC336.15.1:pep; SPBC336.15.
DR GeneID; 2540250; -.
DR KEGG; spo:SPBC336.15; -.
DR PomBase; SPBC336.15; pic1.
DR VEuPathDB; FungiDB:SPBC336.15; -.
DR eggNOG; KOG1181; Eukaryota.
DR HOGENOM; CLU_296495_0_0_1; -.
DR InParanoid; Q1MTN3; -.
DR OMA; ADWSSQD; -.
DR PhylomeDB; Q1MTN3; -.
DR PRO; PR:Q1MTN3; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0032133; C:chromosome passenger complex; TAS:PomBase.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000776; C:kinetochore; IDA:PomBase.
DR GO; GO:0072686; C:mitotic spindle; IDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000070; P:mitotic sister chromatid segregation; IMP:PomBase.
DR InterPro; IPR005635; Inner_centromere_prot_ARK-bd.
DR Pfam; PF03941; INCENP_ARK-bind; 1.
PE 1: Evidence at protein level;
KW Chromosome partition; Cytoplasm; Cytoskeleton; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..1018
FT /note="Inner centromere protein-related protein pic1"
FT /id="PRO_0000255436"
FT REGION 184..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 522..556
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 781..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 848..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 877..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 185..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..287
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..555
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..647
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..666
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 704..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 740..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 781..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..923
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 171
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 1018 AA; 114476 MW; 510368FCD2E8098C CRC64;
MGSNGSELWF NKELEYSQQL TNGKMKEFFF LVSETMDWLN EHMLEVSKLQ LESDIYELVR
TPTKIKEKYS TPRLSPVHRC ALPTPRMRLT SIQHQLEEAA VEGYKSGESN TVKEPKELHT
ATNTETQFDD DRDSTKLSSE YVKDDIVNKS TKGGVSPIKE TRLPTNLPAF SPTSVERRFT
EWNVPLRETS PSPSETADSP NKLPKQKHPA YSFVTLPKRE EILKRPASLH SRVESTNSFI
NQLNRRRTKD NLTNNPEISL DEPIKALPST TSDAPSSLLN TNVSSSPSKF RKFLSSVIPA
KTDLSAKESL TSSTRLSTSY KTRKRSSGVA FSSETVTSSS KERKRSVENE MLKPHPTIFE
SPPEITSFDK SNAVEAEALT AKLKSNEERL PVSSQPGSDA KSQEFDFFEA KIPDSIAKLN
ELTASNENHY ELKTYDRAER LRQKIQEVSS NKRLIPSTPP TKKPINAVLD AAKNSAAKDL
HLAKMKLNNK NDESSLSPAK SHAVITQAPK IPLISTFTRL STRKSSNDFN SSNSRPSSNA
LKSDANENTD SSLPPSKKEF IEKSLHKLSE PLHDDSRQNS DHNFAPHSRP IAIRVATASQ
RELEQTEKRK AKNGAANASN MESRSSENET HRFKKFYGKE RELSNNEFPS RQTKTVTSAN
SSNIRDMEHT ISDKPRSEPD AIPSSKSMHS NKPFEEKSEK PTTKRLVTNP SNVNASWHSN
MLKRQEDLRK KKPLTDNGAT SRHMLKSGLT RVTSKPTQRF ANELAEDMSL AFHSTIPKKM
EPDSVTSVTQ PSVGSLRNNF DIGTTNSQNE DRKKKIAAQK NKNPVHGNVG LTNQHGFKTM
HHNVNPFTKQ NGIMKGKLPS SSTSQSNKPF IEKASMHAPA KGRNSSMQEP SSKSPLLKTP
KSNYFPGYGS LSPNTSVELP EINSDYSDDS DDEGNKKKVN LPSWAESPEL REQLKRQQKW
DPDKIFGMIK PLQMDEYFRS KDRSKIRFRP RSSSADWSSQ DRLTQAEIDN YKKNMGFL
