PIEZ1_CAEEL
ID PIEZ1_CAEEL Reviewed; 2442 AA.
AC A0A061ACU2; A0A061AE33; A0A061AJB7; A0A061AL01; A0A067XG44; B9WRT3; C6KRJ3;
AC D0VWN8; H9G2S2; H9G2S3; O01260; Q17897;
DT 02-DEC-2020, integrated into UniProtKB/Swiss-Prot.
DT 03-SEP-2014, sequence version 1.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=Piezo-type mechanosensitive ion channel component 1 {ECO:0000312|WormBase:C10C5.1g};
GN Name=pezo-1 {ECO:0000312|WormBase:C10C5.1g};
GN ORFNames=C10C5.1 {ECO:0000312|WormBase:C10C5.1g};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP DISRUPTION PHENOTYPE, AND MUTAGENESIS OF ARG-2405.
RX PubMed=32490809; DOI=10.7554/elife.53603;
RA Bai X., Bouffard J., Lord A., Brugman K., Sternberg P.W., Cram E.J.,
RA Golden A.;
RT "Caenorhabditis elegans PIEZO channel coordinates multiple reproductive
RT tissues to govern ovulation.";
RL Elife 9:0-0(2020).
RN [3] {ECO:0007744|PDB:4PKE, ECO:0007744|PDB:4PKX}
RP X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2065-2346, AND MUTAGENESIS OF
RP MET-2094.
RX PubMed=25242456; DOI=10.1016/j.str.2014.08.009;
RA Kamajaya A., Kaiser J.T., Lee J., Reid M., Rees D.C.;
RT "The structure of a conserved piezo channel domain reveals a topologically
RT distinct beta sandwich fold.";
RL Structure 22:1520-1527(2014).
CC -!- FUNCTION: Pore-forming subunit of a mechanosensitive non-specific
CC cation channel (By similarity). Generates currents characterized by a
CC linear current-voltage relationship (By similarity). Plays a role in
CC reproduction by positively regulating inter-tissue signaling to promote
CC oocyte maturation, ovulation and fertilization, and sperm navigation
CC from and to the spermatheca (PubMed:32490809). May play a role in
CC regulating cytosolic and endoplasmic reticulum calcium ion release
CC (PubMed:32490809). {ECO:0000250|UniProtKB:Q92508,
CC ECO:0000269|PubMed:32490809}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32490809};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing, Alternative initiation; Named isoforms=12;
CC Name=g {ECO:0000312|WormBase:C10C5.1g};
CC IsoId=A0A061ACU2-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:C10C5.1a};
CC IsoId=A0A061ACU2-2; Sequence=VSP_060811, VSP_060812;
CC Name=b {ECO:0000312|WormBase:C10C5.1b};
CC IsoId=A0A061ACU2-3; Sequence=VSP_060810, VSP_060811, VSP_060812;
CC Name=c {ECO:0000312|WormBase:C10C5.1c};
CC IsoId=A0A061ACU2-4; Sequence=VSP_060812;
CC Name=d {ECO:0000312|WormBase:C10C5.1d};
CC IsoId=A0A061ACU2-5; Sequence=VSP_060810, VSP_060812;
CC Name=e {ECO:0000312|WormBase:C10C5.1e};
CC IsoId=A0A061ACU2-6; Sequence=VSP_060811;
CC Name=f {ECO:0000312|WormBase:C10C5.1f};
CC IsoId=A0A061ACU2-7; Sequence=VSP_060810, VSP_060811;
CC Name=h {ECO:0000312|WormBase:C10C5.1h};
CC IsoId=A0A061ACU2-8; Sequence=VSP_060810;
CC Name=i {ECO:0000312|WormBase:C10C5.1i};
CC IsoId=A0A061ACU2-9; Sequence=VSP_060808;
CC Name=j {ECO:0000312|WormBase:C10C5.1j};
CC IsoId=A0A061ACU2-10; Sequence=VSP_060808, VSP_060813;
CC Name=k {ECO:0000312|WormBase:C10C5.1k};
CC IsoId=A0A061ACU2-11; Sequence=VSP_060809;
CC Name=l {ECO:0000312|WormBase:C10C5.1l};
CC IsoId=A0A061ACU2-12; Sequence=VSP_060807;
CC -!- TISSUE SPECIFICITY: Expressed in the pharyngeal-intestinal and
CC spermathecal-uterine valves and in multiple reproductive tissues
CC including the germline, somatic oviduct, and spermatheca
CC (PubMed:32490809). During reproduction, it is expressed in sheath
CC cells, sperm, both spermathecal valves and the spermathecal bag cells
CC (PubMed:32490809). {ECO:0000269|PubMed:32490809}.
CC -!- DEVELOPMENTAL STAGE: Expressed from embryogenesis to adulthood
CC (PubMed:32490809). Expressed in one-cell embryos, 4-cell embryos and
CC multi-cell embryos (PubMed:32490809). {ECO:0000269|PubMed:32490809}.
CC -!- DISRUPTION PHENOTYPE: Reduced brood size due to defects in ovulation
CC with incomplete constriction of the sheath cells impairing oocyte
CC transit, an accumulation of ooplasm in the uterus as a result of
CC 'crushed' oocytes, caused by incomplete opening of the spermathecal-
CC uterine valve, which in wild-type allows the fertilized oocyte to be
CC expelled into the uterus, and sperm navigation defects.
CC {ECO:0000269|PubMed:32490809}.
CC -!- MISCELLANEOUS: Piezo comes from the Greek 'piesi' meaning pressure.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform a]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform b]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform c]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform d]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform e]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform f]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform g]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform h]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform i]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform j]: Produced by alternative splicing.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform k]: Produced by alternative initiation at Met-
CC 755 of isoform g. {ECO:0000305}.
CC -!- MISCELLANEOUS: [Isoform l]: Produced by alternative initiation at Met-
CC 1405 of isoform g. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the PIEZO (TC 1.A.75) family. {ECO:0000305}.
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DR EMBL; BX284604; CAA92444.3; -; Genomic_DNA.
DR EMBL; BX284604; CAA92491.3; -; Genomic_DNA.
DR EMBL; BX284604; CAA92492.2; -; Genomic_DNA.
DR EMBL; BX284604; CAX32485.2; -; Genomic_DNA.
DR EMBL; BX284604; CAZ65467.2; -; Genomic_DNA.
DR EMBL; BX284604; CBH29652.2; -; Genomic_DNA.
DR EMBL; BX284604; CCG28215.2; -; Genomic_DNA.
DR EMBL; BX284604; CCG28216.2; -; Genomic_DNA.
DR EMBL; BX284604; CDR32749.1; -; Genomic_DNA.
DR EMBL; BX284604; CDR32750.1; -; Genomic_DNA.
DR EMBL; BX284604; CDR32751.1; -; Genomic_DNA.
DR EMBL; BX284604; CDR32752.1; -; Genomic_DNA.
DR PIR; T25030; T25030.
DR RefSeq; NP_001255385.2; NM_001268456.2. [A0A061ACU2-9]
DR RefSeq; NP_001255386.2; NM_001268457.2. [A0A061ACU2-10]
DR RefSeq; NP_001255387.2; NM_001268458.2. [A0A061ACU2-4]
DR RefSeq; NP_001255388.2; NM_001268459.2. [A0A061ACU2-5]
DR RefSeq; NP_001255389.2; NM_001268460.2. [A0A061ACU2-2]
DR RefSeq; NP_001255390.2; NM_001268461.2. [A0A061ACU2-3]
DR RefSeq; NP_001255391.2; NM_001268462.2. [A0A061ACU2-6]
DR RefSeq; NP_001293677.1; NM_001306748.1. [A0A061ACU2-12]
DR RefSeq; NP_001293979.1; NM_001307050.1. [A0A061ACU2-7]
DR RefSeq; NP_001293980.1; NM_001307051.1. [A0A061ACU2-1]
DR RefSeq; NP_001293981.1; NM_001307052.1. [A0A061ACU2-8]
DR RefSeq; NP_001293982.1; NM_001307053.1.
DR PDB; 4PKE; X-ray; 2.50 A; A=2065-2346.
DR PDB; 4PKX; X-ray; 2.54 A; A=2065-2346.
DR PDBsum; 4PKE; -.
DR PDBsum; 4PKX; -.
DR AlphaFoldDB; A0A061ACU2; -.
DR SMR; A0A061ACU2; -.
DR STRING; 6239.T20D3.11b; -.
DR TCDB; 1.A.75.1.8; the mechanical nociceptor, piezo (piezo) family.
DR EnsemblMetazoa; C10C5.1a.1; C10C5.1a.1; WBGene00007505. [A0A061ACU2-2]
DR EnsemblMetazoa; C10C5.1b.1; C10C5.1b.1; WBGene00007505. [A0A061ACU2-3]
DR EnsemblMetazoa; C10C5.1c.1; C10C5.1c.1; WBGene00007505. [A0A061ACU2-4]
DR EnsemblMetazoa; C10C5.1d.1; C10C5.1d.1; WBGene00007505. [A0A061ACU2-5]
DR EnsemblMetazoa; C10C5.1e.1; C10C5.1e.1; WBGene00007505. [A0A061ACU2-6]
DR EnsemblMetazoa; C10C5.1f.1; C10C5.1f.1; WBGene00007505. [A0A061ACU2-7]
DR EnsemblMetazoa; C10C5.1g.1; C10C5.1g.1; WBGene00007505. [A0A061ACU2-1]
DR EnsemblMetazoa; C10C5.1h.1; C10C5.1h.1; WBGene00007505. [A0A061ACU2-8]
DR EnsemblMetazoa; C10C5.1i.1; C10C5.1i.1; WBGene00007505. [A0A061ACU2-9]
DR EnsemblMetazoa; C10C5.1j.1; C10C5.1j.1; WBGene00007505. [A0A061ACU2-10]
DR EnsemblMetazoa; C10C5.1k.1; C10C5.1k.1; WBGene00007505. [A0A061ACU2-11]
DR EnsemblMetazoa; C10C5.1l.1; C10C5.1l.1; WBGene00007505. [A0A061ACU2-12]
DR GeneID; 182492; -.
DR KEGG; cel:CELE_C10C5.1; -.
DR UCSC; C10C5.1; c. elegans.
DR UCSC; T20D3.11; c. elegans.
DR CTD; 182492; -.
DR WormBase; C10C5.1a; CE49845; WBGene00007505; pezo-1. [A0A061ACU2-2]
DR WormBase; C10C5.1b; CE49903; WBGene00007505; pezo-1. [A0A061ACU2-3]
DR WormBase; C10C5.1c; CE49745; WBGene00007505; pezo-1. [A0A061ACU2-4]
DR WormBase; C10C5.1d; CE49867; WBGene00007505; pezo-1. [A0A061ACU2-5]
DR WormBase; C10C5.1e; CE49888; WBGene00007505; pezo-1. [A0A061ACU2-6]
DR WormBase; C10C5.1f; CE49932; WBGene00007505; pezo-1. [A0A061ACU2-7]
DR WormBase; C10C5.1g; CE49794; WBGene00007505; pezo-1. [A0A061ACU2-1]
DR WormBase; C10C5.1h; CE49859; WBGene00007505; pezo-1. [A0A061ACU2-8]
DR WormBase; C10C5.1i; CE48356; WBGene00007505; pezo-1. [A0A061ACU2-9]
DR WormBase; C10C5.1j; CE48376; WBGene00007505; pezo-1. [A0A061ACU2-10]
DR WormBase; C10C5.1k; CE49828; WBGene00007505; pezo-1. [A0A061ACU2-11]
DR WormBase; C10C5.1l; CE23991; WBGene00007505; pezo-1. [A0A061ACU2-12]
DR eggNOG; KOG1893; Eukaryota.
DR GeneTree; ENSGT00940000166986; -.
DR HOGENOM; CLU_000512_0_0_1; -.
DR OMA; RRITHKM; -.
DR OrthoDB; 13738at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00007505; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; A0A061ACU2; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR GO; GO:0008381; F:mechanosensitive ion channel activity; IBA:GO_Central.
DR GO; GO:0098655; P:cation transmembrane transport; ISS:WormBase.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IBA:GO_Central.
DR GO; GO:0050982; P:detection of mechanical stimulus; IBA:GO_Central.
DR GO; GO:0030317; P:flagellated sperm motility; IMP:UniProtKB.
DR GO; GO:0090727; P:positive regulation of brood size; IMP:UniProtKB.
DR GO; GO:0060279; P:positive regulation of ovulation; IMP:UniProtKB.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0009612; P:response to mechanical stimulus; ISS:WormBase.
DR InterPro; IPR027272; Piezo.
DR InterPro; IPR031805; Piezo_dom.
DR InterPro; IPR031334; Piezo_RRas-bd_dom.
DR PANTHER; PTHR13167; PTHR13167; 1.
DR Pfam; PF15917; PIEZO; 1.
DR Pfam; PF12166; Piezo_RRas_bdg; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative initiation; Alternative splicing; Cell membrane;
KW Glycoprotein; Ion channel; Ion transport; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..2442
FT /note="Piezo-type mechanosensitive ion channel component 1"
FT /id="PRO_0000451574"
FT TOPO_DOM 1..5
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 6..26
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 27
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 28..48
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..56
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 57..77
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 78..122
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 123..143
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 144..173
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 174..196
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 197..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 199..219
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..239
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 240..260
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..303
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 304..324
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 325..454
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 455..475
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 476..478
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 479..499
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 500..506
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 507..527
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 528..552
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 553..573
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 574..633
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 634..654
FT /note="Helical; Name=13"
FT /evidence="ECO:0000255"
FT TOPO_DOM 655..656
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 657..677
FT /note="Helical; Name=14"
FT /evidence="ECO:0000255"
FT TOPO_DOM 678..683
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 684..704
FT /note="Helical; Name=15"
FT /evidence="ECO:0000255"
FT TOPO_DOM 705..739
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 740..760
FT /note="Helical; Name=16"
FT /evidence="ECO:0000255"
FT TOPO_DOM 761..832
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 833..853
FT /note="Helical; Name=17"
FT /evidence="ECO:0000255"
FT TOPO_DOM 854..874
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 875..895
FT /note="Helical; Name=18"
FT /evidence="ECO:0000255"
FT TOPO_DOM 896..931
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 932..952
FT /note="Helical; Name=19"
FT /evidence="ECO:0000255"
FT TOPO_DOM 953..990
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 991..1011
FT /note="Helical; Name=20"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1012
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 1013..1033
FT /note="Helical; Name=21"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1034..1041
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 1042..1062
FT /note="Helical; Name=22"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1063..1096
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 1097..1117
FT /note="Helical; Name=23"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1118..1160
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 1161..1181
FT /note="Helical; Name=24"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1182..1187
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 1188..1210
FT /note="Helical; Name=25"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1211..1231
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 1232..1252
FT /note="Helical; Name=26"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1253..1299
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 1300..1320
FT /note="Helical; Name=27"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1321..1615
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 1616..1636
FT /note="Helical; Name=28"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1637..1654
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 1655..1675
FT /note="Helical; Name=29"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1676..1706
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 1707..1727
FT /note="Helical; Name=30"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1728..1833
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 1834..1854
FT /note="Helical; Name=31"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1855..1866
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 1867..1887
FT /note="Helical; Name=32"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1888..1900
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 1901..1921
FT /note="Helical; Name=33"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1922..1930
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 1931..1951
FT /note="Helical; Name=34"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1952..2046
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 2047..2067
FT /note="Helical; Name=35"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2068..2346
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 2347..2367
FT /note="Helical; Name=36"
FT /evidence="ECO:0000255"
FT TOPO_DOM 2368..2442
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT REGION 389..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 768..798
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1463..1502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 332
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 392
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 440
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 816
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 908
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 913
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1088
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1094
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1646
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 1737
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT VAR_SEQ 1..1404
FT /note="Missing (in isoform l)"
FT /evidence="ECO:0000305"
FT /id="VSP_060807"
FT VAR_SEQ 1..804
FT /note="MTVPPLLKSCVVKLLLPAALLAAAIIRPSFLSIGYVLLALVSAVLPPIRKSL
FT ALPKLVGTFVIITFLFCLAVALGVGSYQISEQVVHKNDRTYICNRSDTTLFRSIGLVRF
FT HPTGTFESTRAFLPEIIATSAALLTIIIVMFLSHRDEQLDVVGDVVTVRSESGREQRRQ
FT RKLAAIMWSAIGNSLRRLTNFVLFLFTAYVGIVKPSLSNSIYFLAFLFISTWWSTYTPL
FT RHGVYNQIKKFLIFYSALHFLVLYTYQIPIVHHSWLPTGSFLPRLFGLTVLMDSSCPEW
FT WKFPFVAPDFNDDDLIMKWPLYANPIVVLVFFYLTVAQYKFTRNGSREYIDDNEYGSSV
FT HEERFVSAGTVETNVDDVGQLISISESTASAPSGRGRGNTLLLSNASSSANDDEQGRAR
FT SRSPLRNGEEQGSIPLRKVTSQVVDRNKLSNIFNTTAPGDKESAASKGMIAVMTFVIFH
FT SYSIALTAMMTWALLYHSIFGLILLILTCILWIFRDTRKSSFAMAPIILMYIEFLLILQ
FT YFLSMDIHAEIGDPAWMNFVGIEWTTLPVHAVIILCVQTLLTLPVFLLLRLARREKFYE
FT SLSDYERQRRINSYGTFGASKTGAGGVAVAKFQDPKSRKFAAFVEYLSNKVSVYFIFVV
FT SVVLLVVSTCFAPNFYNILFFALWALNLIYLKFSFRLYRGLAYAFWLTLTFYTSIVIIA
FT LYIYQFPGVSQWIIRNTSLSQEWLNAIGLVDFRAIGESGALFLQLLAPIALFVVTMLQL
FT KFFHGPWSRATSPRRAENDPPTSTTEAAAVASTSGTQGRAHAAG -> MLTKSIVSSSG
FT DSGIYEDGCGIMPYIDDDDDLTPIIMARPAIGSGYTGGRNGWHRSPRQYLTNWWS (in
FT isoform i and isoform j)"
FT /evidence="ECO:0000305"
FT /id="VSP_060808"
FT VAR_SEQ 1..756
FT /note="Missing (in isoform k)"
FT /evidence="ECO:0000305"
FT /id="VSP_060809"
FT VAR_SEQ 351..388
FT /note="Missing (in isoform b, isoform d, isoform f and
FT isoform h)"
FT /evidence="ECO:0000305"
FT /id="VSP_060810"
FT VAR_SEQ 442..443
FT /note="Missing (in isoform a, isoform b, isoform e and
FT isoform f)"
FT /evidence="ECO:0000305"
FT /id="VSP_060811"
FT VAR_SEQ 615..616
FT /note="Missing (in isoform a, isoform b, isoform c and
FT isoform d)"
FT /evidence="ECO:0000305"
FT /id="VSP_060812"
FT VAR_SEQ 1396
FT /note="H -> HECMRIDEDDPFPYYDLRISSQDTENE (in isoform j)"
FT /evidence="ECO:0000305"
FT /id="VSP_060813"
FT MUTAGEN 2094
FT /note="M->R: Does not cause significant conformational
FT changes the last cytoplasmic domain."
FT /evidence="ECO:0000269|PubMed:25242456"
FT MUTAGEN 2405
FT /note="R->P: Reduces brood size and ovulation rates, and
FT there is an accumulation of ooplasmic uterine masses."
FT /evidence="ECO:0000269|PubMed:32490809"
FT STRAND 2079..2085
FT /evidence="ECO:0007829|PDB:4PKE"
FT STRAND 2091..2096
FT /evidence="ECO:0007829|PDB:4PKE"
FT STRAND 2106..2109
FT /evidence="ECO:0007829|PDB:4PKE"
FT HELIX 2113..2121
FT /evidence="ECO:0007829|PDB:4PKE"
FT HELIX 2130..2143
FT /evidence="ECO:0007829|PDB:4PKX"
FT HELIX 2148..2150
FT /evidence="ECO:0007829|PDB:4PKE"
FT STRAND 2151..2156
FT /evidence="ECO:0007829|PDB:4PKE"
FT HELIX 2168..2179
FT /evidence="ECO:0007829|PDB:4PKE"
FT STRAND 2184..2191
FT /evidence="ECO:0007829|PDB:4PKE"
FT STRAND 2206..2213
FT /evidence="ECO:0007829|PDB:4PKE"
FT HELIX 2218..2229
FT /evidence="ECO:0007829|PDB:4PKE"
FT STRAND 2236..2242
FT /evidence="ECO:0007829|PDB:4PKE"
FT STRAND 2244..2248
FT /evidence="ECO:0007829|PDB:4PKE"
FT STRAND 2250..2253
FT /evidence="ECO:0007829|PDB:4PKE"
FT HELIX 2258..2264
FT /evidence="ECO:0007829|PDB:4PKE"
FT STRAND 2288..2294
FT /evidence="ECO:0007829|PDB:4PKE"
FT STRAND 2305..2310
FT /evidence="ECO:0007829|PDB:4PKE"
FT TURN 2327..2329
FT /evidence="ECO:0007829|PDB:4PKE"
FT STRAND 2334..2340
FT /evidence="ECO:0007829|PDB:4PKE"
SQ SEQUENCE 2442 AA; 276793 MW; FB7D9F5248DB4814 CRC64;
MTVPPLLKSC VVKLLLPAAL LAAAIIRPSF LSIGYVLLAL VSAVLPPIRK SLALPKLVGT
FVIITFLFCL AVALGVGSYQ ISEQVVHKND RTYICNRSDT TLFRSIGLVR FHPTGTFEST
RAFLPEIIAT SAALLTIIIV MFLSHRDEQL DVVGDVVTVR SESGREQRRQ RKLAAIMWSA
IGNSLRRLTN FVLFLFTAYV GIVKPSLSNS IYFLAFLFIS TWWSTYTPLR HGVYNQIKKF
LIFYSALHFL VLYTYQIPIV HHSWLPTGSF LPRLFGLTVL MDSSCPEWWK FPFVAPDFND
DDLIMKWPLY ANPIVVLVFF YLTVAQYKFT RNGSREYIDD NEYGSSVHEE RFVSAGTVET
NVDDVGQLIS ISESTASAPS GRGRGNTLLL SNASSSANDD EQGRARSRSP LRNGEEQGSI
PLRKVTSQVV DRNKLSNIFN TTAPGDKESA ASKGMIAVMT FVIFHSYSIA LTAMMTWALL
YHSIFGLILL ILTCILWIFR DTRKSSFAMA PIILMYIEFL LILQYFLSMD IHAEIGDPAW
MNFVGIEWTT LPVHAVIILC VQTLLTLPVF LLLRLARREK FYESLSDYER QRRINSYGTF
GASKTGAGGV AVAKFQDPKS RKFAAFVEYL SNKVSVYFIF VVSVVLLVVS TCFAPNFYNI
LFFALWALNL IYLKFSFRLY RGLAYAFWLT LTFYTSIVII ALYIYQFPGV SQWIIRNTSL
SQEWLNAIGL VDFRAIGESG ALFLQLLAPI ALFVVTMLQL KFFHGPWSRA TSPRRAENDP
PTSTTEAAAV ASTSGTQGRA HAAGDTLVKK LHKLANQTIE LLWRFFEVHI SKIVFVIIAI
FIANNINALY IPLVILLSLA ICLPSAADGI FSLFMCAYLF LVALSKMIYQ LDIVPELSQI
DRGVGADNCS HGNISMPEWF GLKKEVEGTE PIYMLFGVIV SIIALAFQSI VIYRQRHYRA
SLGLPESMRA KVFPDFHHSH FDRSLKNAIQ FLIDYGFYKF GLEITMIAIG IDIFNRMDAL
AAIQCFWLVL FALNKRVFVR RIWVFYVIYM AILYPLQFFS YVGLPPDSCI EYPWSYWIPS
YSDDARFNLS YLLNLSIYGV NWPSAYLIGD FFVLLLASCQ LAVFRREGED NDSIYNDGNF
VIKPENPQYD FIDTKKSYVD YFKSFVFHYG HWITLMSTLA AGIAGTSLFA LGYIIFTLTM
LWSGNNLYVM NSTLRSFEHT LKRWNALLGY TLFTITMKVC LQIFGCVFLS WFDQSGGWGK
TLCIVRQLFS ITCVNNECHV LKELEDFSKA CAVETKEGNI GFDVIALSFL VFQIRIFHSW
YFQHCMVEYR SEVILANRGA VLKNQLIEKE MKEQNEQQKA KFNDIRRRTE AIRERYQKQI
ERGAAERDFE PVTYGHAKRA GDYYMFKYDP ENDDLVEPVD SFVPEVDPKA TAYDRLDPGQ
IMYAATAHDL DLAKTVQQVK KGDTIKDPDS RALIAVSEPE ARKPGGTEET DGDEDEDNKD
SKVESTAKFI QKMIASALDL CSVTLNKLCR EHRYVGFVLS KEKQKLKSGH SESLSNTSRK
LTDIRSAVDL PSLQLVQSAN DVEKMETAVS VDWQQKSSAT RLLNAVVNCI GAHTDILCYF
FAIMTQVMTG GLITLPLPLM SLFWGNLSNP RPSKFFWVTM ITYTECVIVI KFVCQFAFMP
YNSITWRTEH QMDPMSLDKL FGVSQRDSFA LWDIVLLFSL FFHRYMLRKL GLWKDANLTD
TFTLKEEPRS ASGSDTGSPK KIAQEPKVVV TQSDTLEGTS GGEIVIPSDP NAVSNMEELD
CEPPIPEKQS GPIGRFIHQL FHPKFRYIRD LYPIMFGIDV ICFLIMTFGY SAFGEGGSGN
VLDDVKASRI PVTLVVMLVG MTLAIIIDRA LYLRKSVVGK LIYQVLMIAF LHIWVFLVLP
NMTRRSAISN HVAQALYVIK SCYFLVSAWQ IRNGYPELCI GNLLTHSYGM TNMIAFKVFM
NIPFLFELRT AIDWTWTDTS MPLFDFFNME NFYAHIFNIK CARQFEAAYP APRGIPKGKL
VKYMMGFPII IGVVIFIFSP LLLWSLLNQI GTISMPEKVT LRISIEGYPP LYEMEAQGSN
HDNAELGMIK PDQLASLNQA LTDSYTTRDT NSILRSRMSV SYLKGYTYED ILIVRFRPES
EIYWPISQDS RNAMIDKLSR NTSVNFEVSL EFTRPYDPNE NAALKHSKSW LVPISLDMTI
RAKIQSALRG DPGHPILIPQ SIPAFIQVPN QGELTLPTSI GNTIINDGNP RINTTGMEKS
DEARAWFDSL TLNLEQGKSQ NEKMWIATSE HPGDQNAKLW IKTANTTYSG RPYLQVVGFI
DRAFPSFLAK VFKGGVIAVY LSVILVVGRG LVRGIFTTSP STVMFTELPN ADHLLKICLD
IYLVREAKDF MLEQDLFAKL IFLFRSPATL IEWTRMSKKK QE
