PIF0_NPVAC
ID PIF0_NPVAC Reviewed; 645 AA.
AC P15963;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 29-SEP-2021, entry version 64.
DE RecName: Full=Per os infectivity factor 0;
DE Short=PIF0;
GN Name=P74;
OS Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX NCBI_TaxID=46015;
OH NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2688302; DOI=10.1016/0042-6822(89)90593-x;
RA Kuzio J., Jaques R., Faulkner P.;
RT "Identification of p74, a gene essential for virulence of baculovirus
RT occlusion bodies.";
RL Virology 173:759-763(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C6;
RX PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT virus.";
RL Virology 202:586-605(1994).
RN [3]
RP SUBCELLULAR LOCATION.
RX PubMed=9400957; DOI=10.1099/0022-1317-78-12-3091;
RA Faulkner P., Kuzio J., Williams G.V., Wilson J.A.;
RT "Analysis of p74, a PDV envelope protein of Autographa californica
RT nucleopolyhedrovirus required for occlusion body infectivity in vivo.";
RL J. Gen. Virol. 78:3091-3100(1997).
RN [4]
RP FUNCTION.
RX PubMed=15744572; DOI=10.1007/s11262-004-5623-4;
RA Zhou W., Yao L., Xu H., Yan F., Qi Y.;
RT "The function of envelope protein P74 from Autographa californica multiple
RT nucleopolyhedrovirus in primary infection to host.";
RL Virus Genes 30:139-150(2005).
RN [5]
RP FUNCTION.
RX PubMed=15194753; DOI=10.1128/jvi.78.13.6786-6791.2004;
RA Haas-Stapleton E.J., Washburn J.O., Volkman L.E.;
RT "P74 mediates specific binding of Autographa californica M
RT nucleopolyhedrovirus occlusion-derived virus to primary cellular targets in
RT the midgut epithelia of Heliothis virescens Larvae.";
RL J. Virol. 78:6786-6791(2004).
RN [6]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=20007360; DOI=10.1099/vir.0.017145-0;
RA Slack J.M., Lawrence S.D., Krell P.J., Arif B.M.;
RT "A soluble form of P74 can act as a per os infectivity factor to the
RT Autographa californica multiple nucleopolyhedrovirus.";
RL J. Gen. Virol. 91:915-918(2010).
RN [7]
RP INTERACTION WITH PIF1; PIF2 AND PIF3.
RX PubMed=20610731; DOI=10.1128/jvi.00812-10;
RA Peng K., van Oers M.M., Hu Z., van Lent J.W., Vlak J.M.;
RT "Baculovirus per os infectivity factors form a complex on the surface of
RT occlusion-derived virus.";
RL J. Virol. 84:9497-9504(2010).
CC -!- FUNCTION: Plays an essential role for oral infectivity of occlusion-
CC derived virus (ODV) and functions also in host midgut attachment and
CC fusion by binding to a specific host receptor.
CC {ECO:0000269|PubMed:15194753, ECO:0000269|PubMed:15744572,
CC ECO:0000269|PubMed:20007360}.
CC -!- SUBUNIT: Interacts with the PIF complex composed of PIF1, PIF2 and
CC PIF3. {ECO:0000269|PubMed:20610731}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20007360}. Virion
CC membrane {ECO:0000269|PubMed:9400957}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the baculoviridae p74 family. {ECO:0000305}.
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DR EMBL; M31301; AAA46729.1; -; Genomic_DNA.
DR EMBL; L22858; AAA66768.1; -; Genomic_DNA.
DR PIR; A33750; WMNV74.
DR PIR; C72867; C72867.
DR RefSeq; NP_054168.1; NC_001623.1.
DR GeneID; 1403971; -.
DR KEGG; vg:1403971; -.
DR Proteomes; UP000008292; Genome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0039679; C:viral occlusion body; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019058; P:viral life cycle; IEA:InterPro.
DR InterPro; IPR007663; Baculo_p74.
DR InterPro; IPR013613; Baculo_p74_N.
DR Pfam; PF04583; Baculo_p74; 1.
DR Pfam; PF08404; Baculo_p74_N; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Secreted; Transmembrane; Transmembrane helix;
KW Viral occlusion body; Virion; Virulence.
FT CHAIN 1..645
FT /note="Per os infectivity factor 0"
FT /id="PRO_0000132916"
FT TRANSMEM 437..457
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 590..610
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 611..631
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 73
FT /note="V -> E (in Ref. 1; AAA46729)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="M -> T (in Ref. 1; AAA46729)"
FT /evidence="ECO:0000305"
FT CONFLICT 593
FT /note="L -> M (in Ref. 1; AAA46729)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 645 AA; 73885 MW; 40B9C85146A675F2 CRC64;
MAVLTAVDLT NASRYAIHMH RLEFISRWRT RFPHILIDYT LRPASSDDDY YVPPKLADKA
LAVKLAFSKR GCVSMSCYPF HETGVVSNTT PFMYMQTSET SVGYAQPACY HLDRAAAMRE
GAETQVQSAE FRYTLDNKCI LVDSLSKMYF NSPYLRTEEH TIMGVDDVPA FNVRPDPDPL
FPERFKGEFN EAYCRRFGRE LFNGGCSFRW WESLIGFVLG DTIFVTFKML ANNIFSELRD
FDYKAPSSIL PPRPNVDSNA ILAQWRSVRD NATDLEFEKL FNKNPTLNDL GMIVNGSPVQ
ITYTAETGFT KTPIAYNYRG NERARVEHFE ALDRSISDQD LESIITSFLE DYALVFGIAT
DIGFDMLMSG FKSMLKKINT SLIPAMKHML LSTTRRVTVR MLGETYKAAL VHSLNVIAIK
TLTVTAKALT RIAIQASSIV GIVLILLTLA DLVLALWDPF GYNNMFPREF PDDMSRTFLT
AYFESFDNTT SREIIEFMPE FFSEMVETDD DATFESLFHL LDYVASLEVN SDGQMLNLEE
GDEIEDFDES TLVGQALATS SLYTRMEFMQ YTFRQNTLLS MNKENNNFNQ IILGLFATNT
IVAFTAFVIH TELIFFIFFV IFLMITFYYI IKESYEYYKT IDLLF
