ID   PIF1_NPVAC              Reviewed;         530 AA.
AC   P41672;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   23-FEB-2022, entry version 51.
DE   RecName: Full=Per os infectivity factor 1;
DE            Short=PIF1;
DE   Flags: Precursor;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=16306597; DOI=10.1128/jvi.79.24.15258-15264.2005;
RA   Ohkawa T., Washburn J.O., Sitapara R., Sid E., Volkman L.E.;
RT   "Specific binding of Autographa californica M nucleopolyhedrovirus
RT   occlusion-derived virus to midgut cells of Heliothis virescens larvae is
RT   mediated by products of pif genes Ac119 and Ac022 but not by Ac115.";
RL   J. Virol. 79:15258-15264(2005).
RN   [3]
RP   INTERACTION WITH PIF2; PIF3 AND PIF0.
RX   PubMed=20610731; DOI=10.1128/jvi.00812-10;
RA   Peng K., van Oers M.M., Hu Z., van Lent J.W., Vlak J.M.;
RT   "Baculovirus per os infectivity factors form a complex on the surface of
RT   occlusion-derived virus.";
RL   J. Virol. 84:9497-9504(2010).
CC   -!- FUNCTION: Per os infectivity factor that mediates the specific binding
CC       of occluded virions (ODV) to the host midgut target cells.
CC       {ECO:0000269|PubMed:16306597}.
CC   -!- SUBUNIT: Forms the PIF complex together with PIF2 and PIF3. The complex
CC       interacts also with per os infectivity factor PIF0.
CC       {ECO:0000269|PubMed:20610731}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000269|PubMed:16306597}.
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DR   EMBL; L22858; AAA66749.1; -; Genomic_DNA.
DR   PIR; H72864; H72864.
DR   RefSeq; NP_054149.1; NC_001623.1.
DR   GeneID; 1403952; -.
DR   KEGG; vg:1403952; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007784; PIR.
DR   Pfam; PF05092; PIF; 1.
PE   1: Evidence at protein level;
KW   Membrane; Reference proteome; Signal; Virion.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..530
FT                   /note="Per os infectivity factor 1"
FT                   /id="PRO_0000036755"
SQ   SEQUENCE   530 AA;  59740 MW;  1069BE8899B90830 CRC64;
     MHFAIILLFL LVIIAIVYTY VDLIDVHHEE VRYPITVFDN TRAPLIEPPS EIVIEGNAHE
     CHKTLTPCFT HGDCDLCREG LANCQLFDED TIVKMRGDDG QEHETLIRAG EAYCLALDRE
     RARSCNPNTG VWLLAETETG FALLCNCLRP GLVTQLNMYE DCNVPVGCAP HGRIDNINSA
     SIRCVCDDGY VSDYNADTET PYCRPRTVRD VMYDESFFPR APCADGQVRL DHPALNDFYR
     RHFRLEDICV IDPCSVDPIS GQRTSGRLFH QPTVNGVGIN GCNCPADDGL LPVFNRHTAD
     TGMVRQSDRT VANACLQPFN VHMLSLRHVD YKFFWGRSDH TEFADADMVF QANVNQLSHE
     RYRAILYSLL ESHPDVTEIV TVNMGVMKIS VSYDTTLKNI LLPSSVFRLF RFKESGTAQP
     VCFFPGVGRC ITVNSDSCIR RHAGGQVWTA ETFTNSWCVL SREGTHIKVW SRASRYPRGD
     APAALRLRGF FLNNDRERNT IRAVTTGDMT QGQQIDALTQ ILETYPNYSV