ID   PIF2_NPVAC              Reviewed;         382 AA.
AC   P41427;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   29-SEP-2021, entry version 51.
DE   RecName: Full=Per os infectivity factor 2;
DE            Short=PIF2;
DE   AltName: Full=ORF 8/6;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=E2;
RX   PubMed=1333113; DOI=10.1016/0042-6822(92)90281-s;
RA   Braunagel S.C., Daniel K.D., Reilly L.M., Guarino L.A., Hong T.,
RA   Summers M.D.;
RT   "Sequence, genomic organization of the EcoRI-A fragment of Autographa
RT   californica nuclear polyhedrosis virus, and identification of a viral-
RT   encoded protein resembling the outer capsid protein VP8 of rotavirus.";
RL   Virology 191:1003-1008(1992).
RN   [3]
RP   FUNCTION.
RX   PubMed=16306597; DOI=10.1128/jvi.79.24.15258-15264.2005;
RA   Ohkawa T., Washburn J.O., Sitapara R., Sid E., Volkman L.E.;
RT   "Specific binding of Autographa californica M nucleopolyhedrovirus
RT   occlusion-derived virus to midgut cells of Heliothis virescens larvae is
RT   mediated by products of pif genes Ac119 and Ac022 but not by Ac115.";
RL   J. Virol. 79:15258-15264(2005).
RN   [4]
RP   INTERACTION WITH PIF1; PIF3 AND PIF0.
RX   PubMed=20610731; DOI=10.1128/jvi.00812-10;
RA   Peng K., van Oers M.M., Hu Z., van Lent J.W., Vlak J.M.;
RT   "Baculovirus per os infectivity factors form a complex on the surface of
RT   occlusion-derived virus.";
RL   J. Virol. 84:9497-9504(2010).
CC   -!- FUNCTION: Per os infectivity factor that mediates the specific binding
CC       of occluded virions (ODV) to the host midgut target cells.
CC   -!- SUBUNIT: Forms the PIF complex together with PIF1 and PIF3. The complex
CC       interacts also with per os infectivity factor PIF0.
CC       {ECO:0000269|PubMed:20610731}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA66792.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; L22858; AAA66652.1; -; Genomic_DNA.
DR   EMBL; M96361; AAA66792.1; ALT_SEQ; Genomic_DNA.
DR   PIR; F72852; F72852.
DR   PIR; H44221; H44221.
DR   RefSeq; NP_054051.1; NC_001623.1.
DR   GeneID; 1403854; -.
DR   KEGG; vg:1403854; -.
DR   Proteomes; UP000008292; Genome.
DR   InterPro; IPR006725; PIF2.
DR   Pfam; PF04631; PIF2; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..382
FT                   /note="Per os infectivity factor 2"
FT                   /id="PRO_0000132957"
SQ   SEQUENCE   382 AA;  43777 MW;  71A791B7F245A13C CRC64;
     MYRVLIVFFL FVFLYIVYQP FYQAYLHIGH AQQDYNDTLD DRMDYIESVM RRRHYVPIEA
     LPAIRFDTNL GTLAGDTIKC MSVPLFVSDI DLPMFDCSQI CDNPSAAYFF VNETDVFVVN
     GHRLTVGGYC STNSLPRNCN RETSVILMSL NQWTCIAEDP RYYAGTDNMT QLAGRQHFDR
     IMPGQSDRNV LFDRLLGREV NVTTNTFRRS WDELLEDGTR RFEMRCNARD NNNNLMFVNP
     LNPLECLPNV CTNVSNVHTS VRPVFETGEC DCGDEAVTRV THIVPGDRTS MCASIIDGLD
     KSTASYRYRV ECVNLYTSIL NYSNNKLLCP SDTFDSNTDA AFAFEVPGSY PLSRNGINEP
     TYRFYLDTRS RVNYNDVRGQ LS