ID   PIF4_NPVAC              Reviewed;         173 AA.
AC   P41656;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Per os infectivity factor 4;
DE            Short=PIF4;
DE   Flags: Precursor;
GN   Name=AC96; ORFNames=ORF96;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=HR3;
RX   PubMed=1994581; DOI=10.1016/0042-6822(91)90500-b;
RA   Lu A., Carstens E.B.;
RT   "Nucleotide sequence of a gene essential for viral DNA replication in the
RT   baculovirus Autographa californica nuclear polyhedrosis virus.";
RL   Virology 181:336-347(1991).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=19759145; DOI=10.1128/jvi.01141-09;
RA   Fang M., Nie Y., Harris S., Erlandson M.A., Theilmann D.A.;
RT   "Autographa californica multiple nucleopolyhedrovirus core gene ac96
RT   encodes a per Os infectivity factor (PIF-4).";
RL   J. Virol. 83:12569-12578(2009).
CC   -!- FUNCTION: Per os factor that plays an essential role in the initiation
CC       of host midgut infection. May form a specific complex with PIF1, PIF2
CC       and P74 to bind host receptors. {ECO:0000269|PubMed:19759145}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000269|PubMed:19759145}.
CC       Host cytoplasm {ECO:0000269|PubMed:19759145}. Host nucleus
CC       {ECO:0000269|PubMed:19759145}. Note=Present in the envelope fractions
CC       of both budded virions (BV) and occlusion-derived virus (ODV).
CC       {ECO:0000269|PubMed:19759145}.
CC   -!- SIMILARITY: Belongs to the baculoviridae 19 kDa protein family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L22858; AAA66726.1; -; Genomic_DNA.
DR   EMBL; M57687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PIR; A72862; A72862.
DR   RefSeq; NP_054126.1; NC_001623.1.
DR   SMR; P41656; -.
DR   GeneID; 1403929; -.
DR   KEGG; vg:1403929; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006883; AcMNPV_PIF-4.
DR   Pfam; PF04798; Baculo_19; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Membrane; Reference proteome; Signal; Virion.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..173
FT                   /note="Per os infectivity factor 4"
FT                   /id="PRO_0000133027"
SQ   SEQUENCE   173 AA;  19840 MW;  674040AD63731115 CRC64;
     MLSIMLAIVF VLFVLIYLII SIKNHHPFLH RIETLIQDFN NTLLFGAYVQ IYDLSTPART
     ERLFIIAPEN VVLYNFNKTL YYYLDSANVF CPNEFSVTTF TQSTIKTINE TGIYATACTP
     VSSLTLIEHF ATLKNNVPDH TLVLDVVDQQ IQFSILDIIN YLIYNGYVDL LAE