ID   PIF5_NPVAC              Reviewed;         376 AA.
AC   P41705;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   29-SEP-2021, entry version 73.
DE   RecName: Full=Per os infectivity factor 5;
DE            Short=PIF5;
DE   AltName: Full=E56;
GN   Name=E56; ORFNames=ORF148;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBCELLULAR LOCATION.
RC   STRAIN=E2;
RX   PubMed=8599240; DOI=10.1006/viro.1996.0097;
RA   Braunagel S.C., Elton D.M., Ma H., Summers M.D.;
RT   "Identification and analysis of an Autographa californica nuclear
RT   polyhedrosis virus structural protein of the occlusion-derived virus
RT   envelope: ODV-E56.";
RL   Virology 217:97-110(1996).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=20444894; DOI=10.1128/jvi.00040-10;
RA   Wang R., Deng F., Hou D., Zhao Y., Guo L., Wang H., Hu Z.;
RT   "Proteomics of the Autographa californica nucleopolyhedrovirus budded
RT   virions.";
RL   J. Virol. 84:7233-7242(2010).
RN   [4]
RP   FUNCTION.
RX   PubMed=20970820; DOI=10.1016/j.virol.2010.09.027;
RA   Sparks W.O., Harrison R.L., Bonning B.C.;
RT   "Autographa californica multiple nucleopolyhedrovirus ODV-E56 is a per os
RT   infectivity factor, but is not essential for binding and fusion of
RT   occlusion-derived virus to the host midgut.";
RL   Virology 409:69-76(2011).
CC   -!- FUNCTION: Structural protein that plays a role in the first steps of
CC       per os larva infection. {ECO:0000269|PubMed:20970820}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000269|PubMed:20444894,
CC       ECO:0000269|PubMed:8599240}. Note=Present in both the budded virus (BV)
CC       and the occluded virus (OV). The occluded form allows the virus to be
CC       transmitted from insect to insect through ingestion of contaminated
CC       food while the budded form is responsible for the dissemination of
CC       infection throughout the insect host. {ECO:0000269|PubMed:20444894,
CC       ECO:0000269|PubMed:8599240}.
CC   -!- MISCELLANEOUS: Expressed late in infection. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the baculoviridae E56 family. {ECO:0000305}.
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DR   EMBL; L22858; AAA66778.1; -; Genomic_DNA.
DR   EMBL; U09501; AAA98967.1; -; Genomic_DNA.
DR   PIR; F72868; F72868.
DR   RefSeq; NP_054179.1; NC_001623.1.
DR   GeneID; 1403981; -.
DR   KEGG; vg:1403981; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006733; Baculo_ODV-E56.
DR   Pfam; PF04639; Baculo_E56; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Late protein; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Viral envelope protein; Virion.
FT   CHAIN           1..376
FT                   /note="Per os infectivity factor 5"
FT                   /id="PRO_0000132923"
FT   TRANSMEM        154..174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        183
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   376 AA;  40863 MW;  CA962F5519304AC6 CRC64;
     MSFFSNLRAV NKLYPNQASF ITDNTRLLTS TPAGFTNVLN APSVRNIGNN RFQPGYQLSN
     NQFVSTSDIN RITRNNDVPN IRGVFQGISD PQINSLSQLR RVDNVPDFNY HTKQTRSNAV
     KQNFPETNVR TPEGVQNALQ QNPRLHSYMQ SLKVGGTGIL LATGGYFLFS AATLVQDIIN
     AINNTGGSYY VQGKDAGEIA EACLLLQRTC RQDPNLNQSD VTICPFDPLL PNNPPELTNM
     CQGFNYEVEK TVCRGSDPSA DPDSPQYVDI SDLPAGQTLM CIEPYSFGDL VGDLGLDWLL
     GDEGLVGKSS NVSDSVSGKL MPIILLIGAV LFLGLIFYFI YRYMMKGGGG GGVGAATSPT
     PIVISMQNPT PTTAPR