PIG10_CLAP2
ID PIG10_CLAP2 Reviewed; 467 AA.
AC M1WG94;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2013, sequence version 1.
DT 03-AUG-2022, entry version 23.
DE RecName: Full=Ergochrome gene cluster transcriptional coactivator CPUR_05432 {ECO:0000303|PubMed:28955461};
DE AltName: Full=Ergochrome gene cluster protein CPUR_05432 {ECO:0000303|PubMed:28955461};
GN ORFNames=CPUR_05432;
OS Claviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Claviceps.
OX NCBI_TaxID=1111077;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=20.1;
RX PubMed=23468653; DOI=10.1371/journal.pgen.1003323;
RA Schardl C.L., Young C.A., Hesse U., Amyotte S.G., Andreeva K., Calie P.J.,
RA Fleetwood D.J., Haws D.C., Moore N., Oeser B., Panaccione D.G.,
RA Schweri K.K., Voisey C.R., Farman M.L., Jaromczyk J.W., Roe B.A.,
RA O'Sullivan D.M., Scott B., Tudzynski P., An Z., Arnaoudova E.G.,
RA Bullock C.T., Charlton N.D., Chen L., Cox M., Dinkins R.D., Florea S.,
RA Glenn A.E., Gordon A., Gueldener U., Harris D.R., Hollin W., Jaromczyk J.,
RA Johnson R.D., Khan A.K., Leistner E., Leuchtmann A., Li C., Liu J., Liu J.,
RA Liu M., Mace W., Machado C., Nagabhyru P., Pan J., Schmid J., Sugawara K.,
RA Steiner U., Takach J.E., Tanaka E., Webb J.S., Wilson E.V., Wiseman J.L.,
RA Yoshida R., Zeng Z.;
RT "Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of the
RT Clavicipitaceae reveals dynamics of alkaloid loci.";
RL PLoS Genet. 9:E1003323-E1003323(2013).
RN [2]
RP FUNCTION, AND INDUCTION.
RX PubMed=28955461; DOI=10.1186/s40694-016-0020-z;
RA Neubauer L., Dopstadt J., Humpf H.U., Tudzynski P.;
RT "Identification and characterization of the ergochrome gene cluster in the
RT plant pathogenic fungus Claviceps purpurea.";
RL Fungal Biol. Biotechnol. 3:2-2(2016).
CC -!- FUNCTION: Transcriptional coactivator; part of the gene cluster
CC responsible for the typical purple-black color of the ergot sclerotia
CC (PubMed:28955461). The ergochrome gene cluster produces several ergot
CC pigments including the yellow ergochrome secalonic acid and its
CC derivatives, as well as the red anthraquinones endocrocin and
CC clavorubin (PubMed:28955461). With CPUR_05433, coregulates the
CC production of geodin (PubMed:28955461). {ECO:0000305|PubMed:28955461}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Expression correlates with the formation of the sclerotia
CC and thus the pigment production (PubMed:28955461).
CC {ECO:0000269|PubMed:28955461}.
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DR EMBL; CAGA01000032; CCE31579.1; -; Genomic_DNA.
DR AlphaFoldDB; M1WG94; -.
DR SMR; M1WG94; -.
DR STRING; 1111077.M1WG94; -.
DR EnsemblFungi; CCE31579; CCE31579; CPUR_05432.
DR VEuPathDB; FungiDB:CPUR_05432; -.
DR eggNOG; KOG3178; Eukaryota.
DR HOGENOM; CLU_005533_11_0_1; -.
DR OrthoDB; 817726at2759; -.
DR Proteomes; UP000016801; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; -; 1.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome.
FT CHAIN 1..467
FT /note="Ergochrome gene cluster transcriptional coactivator
FT CPUR_05432"
FT /id="PRO_0000443982"
FT DOMAIN 109..179
FT /note="HTH iclR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
FT DNA_BIND 139..158
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00393"
SQ SEQUENCE 467 AA; 50328 MW; 3B01A50ED44E9A9D CRC64;
MEKLAALKKL PSILRPLLTS KSSYHRVPSD RPTIMDAATS EQLHGLTNRL LTEVNALVSS
YSSIDCQHPF LAAACESQND GSEARSNILS SLSEIEAIVR GPKEFLENIA IQCEMLGSIQ
WLGEFQILAC IPLSQEVPIQ DVANLSNVPE QQLAQMIGLT ARCGFLIEPR RGYVAHTPLS
ASFVTNPSHL DAAMFLAEQA APAALKSATA TQRFTESHTN NETAFSLATT TKVPFEAAQE
QSPRLSRQWA AYLHHAGGLP EDHVLADAMA KLHWSNISKA GGQVVEVGAF LAAKPLARLF
PQLRFLVQLP AGASSCESIL CDPSDPIKPG QISIANRVPG SPQSVTNAAV YVLHLPSSVP
SQILTELQVH LPALRMSNGV MLIMSGRVLP GQDEPIRARH AAVAHARGLI MYQMSNEVEM
DLSSLLQMLD TVRDSTGKLV LVHKLRSCSG MTVAVVVKYQ LMAGGAS