PIG11_CLAP2
ID PIG11_CLAP2 Reviewed; 488 AA.
AC M1W853;
DT 25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2013, sequence version 1.
DT 25-MAY-2022, entry version 30.
DE RecName: Full=Ergochrome gene cluster transcriptional regulator CPUR_05433 {ECO:0000303|PubMed:28955461};
DE AltName: Full=Ergochrome gene cluster protein CPUR_05433 {ECO:0000303|PubMed:28955461};
GN ORFNames=CPUR_05433;
OS Claviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Clavicipitaceae; Claviceps.
OX NCBI_TaxID=1111077;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=20.1;
RX PubMed=23468653; DOI=10.1371/journal.pgen.1003323;
RA Schardl C.L., Young C.A., Hesse U., Amyotte S.G., Andreeva K., Calie P.J.,
RA Fleetwood D.J., Haws D.C., Moore N., Oeser B., Panaccione D.G.,
RA Schweri K.K., Voisey C.R., Farman M.L., Jaromczyk J.W., Roe B.A.,
RA O'Sullivan D.M., Scott B., Tudzynski P., An Z., Arnaoudova E.G.,
RA Bullock C.T., Charlton N.D., Chen L., Cox M., Dinkins R.D., Florea S.,
RA Glenn A.E., Gordon A., Gueldener U., Harris D.R., Hollin W., Jaromczyk J.,
RA Johnson R.D., Khan A.K., Leistner E., Leuchtmann A., Li C., Liu J., Liu J.,
RA Liu M., Mace W., Machado C., Nagabhyru P., Pan J., Schmid J., Sugawara K.,
RA Steiner U., Takach J.E., Tanaka E., Webb J.S., Wilson E.V., Wiseman J.L.,
RA Yoshida R., Zeng Z.;
RT "Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of the
RT Clavicipitaceae reveals dynamics of alkaloid loci.";
RL PLoS Genet. 9:E1003323-E1003323(2013).
RN [2]
RP FUNCTION, AND INDUCTION.
RX PubMed=28955461; DOI=10.1186/s40694-016-0020-z;
RA Neubauer L., Dopstadt J., Humpf H.U., Tudzynski P.;
RT "Identification and characterization of the ergochrome gene cluster in the
RT plant pathogenic fungus Claviceps purpurea.";
RL Fungal Biol. Biotechnol. 3:2-2(2016).
CC -!- FUNCTION: Transcription factor; part of the gene cluster responsible
CC for the typical purple-black color of the ergot sclerotia
CC (PubMed:28955461). The ergochrome gene cluster produces several ergot
CC pigments including the yellow ergochrome secalonic acid and its
CC derivatives, as well as the red anthraquinones endocrocin and
CC clavorubin (PubMed:28955461). {ECO:0000269|PubMed:28955461}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- INDUCTION: Expression correlates with the formation of the sclerotia
CC and thus the pigment production (PubMed:28955461).
CC {ECO:0000269|PubMed:28955461}.
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DR EMBL; CAGA01000032; CCE31580.1; -; Genomic_DNA.
DR AlphaFoldDB; M1W853; -.
DR SMR; M1W853; -.
DR EnsemblFungi; CCE31580; CCE31580; CPUR_05433.
DR VEuPathDB; FungiDB:CPUR_05433; -.
DR eggNOG; ENOG502SU4Z; Eukaryota.
DR HOGENOM; CLU_031656_1_0_1; -.
DR OrthoDB; 1396569at2759; -.
DR PhylomeDB; M1W853; -.
DR Proteomes; UP000016801; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045122; P:aflatoxin biosynthetic process; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR013700; AflR.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF08493; AflR; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..488
FT /note="Ergochrome gene cluster transcriptional regulator
FT CPUR_05433"
FT /id="PRO_0000443983"
FT DNA_BIND 36..63
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 488 AA; 52183 MW; 5F6F7C72B4DF93C4 CRC64;
MDHSIGGRNC QSGGTTASAP RSTGSDEFPS KLRETCHACS LSKVRCSKEK PSCSRCAKRG
VPCEYIVTKR PGRKRDPTKS AGLTSSHCKS FDAATAAPNN TNANCAWLED VLLTDMGGSG
GGSTGHAYLD STQTDTGSPM LWPLMANDGA DIAGDMSDFL MPLITPLSCT FTARTPDFLS
AAAEFSAPIS PPNNHDDKNN NQSMQDGSNV MQLLLPDDVH GGHAAENAAQ EAPSVDFHSS
CSSRSLSSVP ESFLSSKIAS NSDFGSASSS CECLIKALDI MAKVSSTDLA VTPDTPSTRR
NSVQDEAVVA GHDQTSPLLH ATFMANKQTI EALSNMLHGS CQENVYLLTC MSMIVFKVLR
RYEMAAGQSI SAGVLDMHEA ARPRHGDLDR DSLRRAAAQL VLGELHLVQQ LVSRLSRRLQ
LSMDKTPNDG ADSELSDSTL ATRVFTLDED DKADTSAFSA ATLSQMDHDL RKGLARLSSN
IINMLRRL