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PIG11_CLAP2
ID   PIG11_CLAP2             Reviewed;         488 AA.
AC   M1W853;
DT   25-APR-2018, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2013, sequence version 1.
DT   25-MAY-2022, entry version 30.
DE   RecName: Full=Ergochrome gene cluster transcriptional regulator CPUR_05433 {ECO:0000303|PubMed:28955461};
DE   AltName: Full=Ergochrome gene cluster protein CPUR_05433 {ECO:0000303|PubMed:28955461};
GN   ORFNames=CPUR_05433;
OS   Claviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Claviceps.
OX   NCBI_TaxID=1111077;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=20.1;
RX   PubMed=23468653; DOI=10.1371/journal.pgen.1003323;
RA   Schardl C.L., Young C.A., Hesse U., Amyotte S.G., Andreeva K., Calie P.J.,
RA   Fleetwood D.J., Haws D.C., Moore N., Oeser B., Panaccione D.G.,
RA   Schweri K.K., Voisey C.R., Farman M.L., Jaromczyk J.W., Roe B.A.,
RA   O'Sullivan D.M., Scott B., Tudzynski P., An Z., Arnaoudova E.G.,
RA   Bullock C.T., Charlton N.D., Chen L., Cox M., Dinkins R.D., Florea S.,
RA   Glenn A.E., Gordon A., Gueldener U., Harris D.R., Hollin W., Jaromczyk J.,
RA   Johnson R.D., Khan A.K., Leistner E., Leuchtmann A., Li C., Liu J., Liu J.,
RA   Liu M., Mace W., Machado C., Nagabhyru P., Pan J., Schmid J., Sugawara K.,
RA   Steiner U., Takach J.E., Tanaka E., Webb J.S., Wilson E.V., Wiseman J.L.,
RA   Yoshida R., Zeng Z.;
RT   "Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of the
RT   Clavicipitaceae reveals dynamics of alkaloid loci.";
RL   PLoS Genet. 9:E1003323-E1003323(2013).
RN   [2]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=28955461; DOI=10.1186/s40694-016-0020-z;
RA   Neubauer L., Dopstadt J., Humpf H.U., Tudzynski P.;
RT   "Identification and characterization of the ergochrome gene cluster in the
RT   plant pathogenic fungus Claviceps purpurea.";
RL   Fungal Biol. Biotechnol. 3:2-2(2016).
CC   -!- FUNCTION: Transcription factor; part of the gene cluster responsible
CC       for the typical purple-black color of the ergot sclerotia
CC       (PubMed:28955461). The ergochrome gene cluster produces several ergot
CC       pigments including the yellow ergochrome secalonic acid and its
CC       derivatives, as well as the red anthraquinones endocrocin and
CC       clavorubin (PubMed:28955461). {ECO:0000269|PubMed:28955461}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- INDUCTION: Expression correlates with the formation of the sclerotia
CC       and thus the pigment production (PubMed:28955461).
CC       {ECO:0000269|PubMed:28955461}.
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DR   EMBL; CAGA01000032; CCE31580.1; -; Genomic_DNA.
DR   AlphaFoldDB; M1W853; -.
DR   SMR; M1W853; -.
DR   EnsemblFungi; CCE31580; CCE31580; CPUR_05433.
DR   VEuPathDB; FungiDB:CPUR_05433; -.
DR   eggNOG; ENOG502SU4Z; Eukaryota.
DR   HOGENOM; CLU_031656_1_0_1; -.
DR   OrthoDB; 1396569at2759; -.
DR   PhylomeDB; M1W853; -.
DR   Proteomes; UP000016801; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045122; P:aflatoxin biosynthetic process; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR013700; AflR.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF08493; AflR; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..488
FT                   /note="Ergochrome gene cluster transcriptional regulator
FT                   CPUR_05433"
FT                   /id="PRO_0000443983"
FT   DNA_BIND        36..63
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..25
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   488 AA;  52183 MW;  5F6F7C72B4DF93C4 CRC64;
     MDHSIGGRNC QSGGTTASAP RSTGSDEFPS KLRETCHACS LSKVRCSKEK PSCSRCAKRG
     VPCEYIVTKR PGRKRDPTKS AGLTSSHCKS FDAATAAPNN TNANCAWLED VLLTDMGGSG
     GGSTGHAYLD STQTDTGSPM LWPLMANDGA DIAGDMSDFL MPLITPLSCT FTARTPDFLS
     AAAEFSAPIS PPNNHDDKNN NQSMQDGSNV MQLLLPDDVH GGHAAENAAQ EAPSVDFHSS
     CSSRSLSSVP ESFLSSKIAS NSDFGSASSS CECLIKALDI MAKVSSTDLA VTPDTPSTRR
     NSVQDEAVVA GHDQTSPLLH ATFMANKQTI EALSNMLHGS CQENVYLLTC MSMIVFKVLR
     RYEMAAGQSI SAGVLDMHEA ARPRHGDLDR DSLRRAAAQL VLGELHLVQQ LVSRLSRRLQ
     LSMDKTPNDG ADSELSDSTL ATRVFTLDED DKADTSAFSA ATLSQMDHDL RKGLARLSSN
     IINMLRRL
 
 
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