PIG1_DROME
ID PIG1_DROME Reviewed; 172 AA.
AC P26023; C9QP90; O76914; Q24519; Q3Y420; Q95SA5; Q9W4T3;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 4.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Pre-intermoult gene 1 protein;
DE AltName: Full=Gland-specific protein;
DE Flags: Precursor;
GN Name=Pig1; Synonyms=gsg, Pig-1; ORFNames=CG10790;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=Karsnas, Oregon-R, and Samarkand;
RX PubMed=3125018; DOI=10.1007/bf00285876;
RA Hofmann A., Korge G.;
RT "Upstream sequences of dosage-compensated and non-compensated alleles of
RT the larval secretion protein gene Sgs-4 in Drosophila.";
RL Chromosoma 96:1-7(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Canton-S;
RX PubMed=1769273; DOI=10.1007/bf00360686;
RA Furia M., Digilio F.A., Artiaco D., D'Avino P.P., Cavaliere D.,
RA Polito L.C.;
RT "Molecular organization of the Drosophila melanogaster Pig-1 gene.";
RL Chromosoma 101:49-54(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oregon-R;
RX PubMed=10731137; DOI=10.1126/science.287.5461.2220;
RA Benos P.V., Gatt M.K., Ashburner M., Murphy L., Harris D., Barrell B.G.,
RA Ferraz C., Vidal S., Brun C., Demailles J., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Borkova D., Minana B., Kafatos F.C.,
RA Louis C., Siden-Kiamos I., Bolshakov S., Papagiannakis G., Spanos L.,
RA Cox S., Madueno E., de Pablos B., Modolell J., Peter A., Schoettler P.,
RA Werner M., Mourkioti F., Beinert N., Dowe G., Schaefer U., Jaeckle H.,
RA Bucheton A., Callister D.M., Campbell L.A., Darlamitsou A., Henderson N.S.,
RA McMillan P.J., Salles C., Tait E.A., Valenti P., Saunders R.D.C.,
RA Glover D.M.;
RT "From sequence to chromosome: the tip of the X chromosome of D.
RT melanogaster.";
RL Science 287:2220-2222(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Ovary;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- TISSUE SPECIFICITY: Low expression in first to third instar larvae
CC salivary glands. {ECO:0000269|PubMed:3125018}.
CC -!- DEVELOPMENTAL STAGE: Throughout the larval period.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA07070.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAA28893.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAL28436.1; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
CC Sequence=CAA33767.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; M24138; AAA28893.1; ALT_SEQ; Genomic_DNA.
DR EMBL; S77478; AAA07070.1; ALT_FRAME; mRNA.
DR EMBL; X15760; CAA33767.1; ALT_FRAME; mRNA.
DR EMBL; AE014298; AAF45859.2; -; Genomic_DNA.
DR EMBL; AL024484; CAA19669.1; -; Genomic_DNA.
DR EMBL; AY060888; AAL28436.1; ALT_SEQ; mRNA.
DR EMBL; BT099972; ACX53653.1; -; mRNA.
DR PIR; A56579; A56579.
DR RefSeq; NP_476677.2; NM_057329.4.
DR AlphaFoldDB; P26023; -.
DR IntAct; P26023; 5.
DR STRING; 7227.FBpp0070512; -.
DR PaxDb; P26023; -.
DR DNASU; 31303; -.
DR EnsemblMetazoa; FBtr0070537; FBpp0070512; FBgn0003086.
DR GeneID; 31303; -.
DR KEGG; dme:Dmel_CG10790; -.
DR CTD; 31303; -.
DR FlyBase; FBgn0003086; Pig1.
DR VEuPathDB; VectorBase:FBgn0003086; -.
DR HOGENOM; CLU_110400_0_0_1; -.
DR OMA; CLGMCLA; -.
DR BioGRID-ORCS; 31303; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31303; -.
DR PRO; PR:P26023; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0003086; Expressed in saliva-secreting gland and 9 other tissues.
DR Genevisible; P26023; DM.
PE 2: Evidence at transcript level;
KW Reference proteome; Repeat; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..172
FT /note="Pre-intermoult gene 1 protein"
FT /id="PRO_0000022061"
FT REPEAT 27..32
FT /note="1"
FT REPEAT 33..38
FT /note="2"
FT REPEAT 39..44
FT /note="3"
FT REGION 25..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 27..44
FT /note="3 X 6 AA tandem repeats of S-S-A-D-S-D"
FT COMPBIAS 40..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..92
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..124
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..172
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 39..44
FT /note="Missing (in Ref. 1; AAA28893, 2; AAA07070 and 5;
FT CAA19669)"
FT /evidence="ECO:0000305"
FT CONFLICT 53
FT /note="I -> R (in Ref. 1; AAA28893 and 2; AAA07070)"
FT /evidence="ECO:0000305"
FT CONFLICT 53
FT /note="I -> T (in Ref. 5; CAA19669)"
FT /evidence="ECO:0000305"
FT CONFLICT 127
FT /note="A -> AN (in Ref. 1; AAA28893, 2; AAA07070 and 5;
FT CAA19669)"
FT /evidence="ECO:0000305"
FT CONFLICT 160
FT /note="N -> NS (in Ref. 2; AAA07070 and 5; CAA19669)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 172 AA; 18504 MW; 9C5AD36BCD0B74A0 CRC64;
MKLTKLWLLF VCLGLFVTLV VSADTDSDAD SDSSADSDSS ADSDENTTAS GSIVTSTTES
SATNSSGSSD DASGSSSDVD DGSDDDTDSG SDTDYDTPTT APVVKKRANR KKANNNKKRA
SNNRKKANNN NNNKKRANSN NNRKRRASNN NNKKKASNNN NRRRNNNSRR RG
