PIG1_YEAST
ID PIG1_YEAST Reviewed; 648 AA.
AC Q06216; D6VYS0; E9P964;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Serine/threonine-protein phosphatase 1 regulatory subunit PIG1;
GN Name=PIG1; OrderedLocusNames=YLR273C; ORFNames=L9328.2;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP PARTIAL NUCLEOTIDE SEQUENCE, AND CHARACTERIZATION.
RX PubMed=9046081;
RX DOI=10.1002/(sici)1097-0061(199701)13:1<1::aid-yea49>3.0.co;2-f;
RA Cheng C., Huang D., Roach P.J.;
RT "Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that
RT interacts with the yeast glycogen synthase Gsy2p.";
RL Yeast 13:1-8(1997).
CC -!- FUNCTION: Regulates the activity of glycogen synthase. It is most
CC probably a regulatory subunit for protein phosphatase type 1.
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DR EMBL; U17245; AAB67365.1; -; Genomic_DNA.
DR EMBL; AY723846; AAU09763.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09586.1; -; Genomic_DNA.
DR PIR; S51409; S51409.
DR RefSeq; NP_013375.1; NM_001182160.1.
DR AlphaFoldDB; Q06216; -.
DR BioGRID; 31541; 47.
DR DIP; DIP-2918N; -.
DR IntAct; Q06216; 9.
DR MINT; Q06216; -.
DR STRING; 4932.YLR273C; -.
DR CAZy; CBM21; Carbohydrate-Binding Module Family 21.
DR iPTMnet; Q06216; -.
DR PaxDb; Q06216; -.
DR PRIDE; Q06216; -.
DR EnsemblFungi; YLR273C_mRNA; YLR273C; YLR273C.
DR GeneID; 850979; -.
DR KEGG; sce:YLR273C; -.
DR SGD; S000004263; PIG1.
DR VEuPathDB; FungiDB:YLR273C; -.
DR eggNOG; KOG3986; Eukaryota.
DR GeneTree; ENSGT00940000176558; -.
DR HOGENOM; CLU_028211_0_0_1; -.
DR OMA; IDCEIEP; -.
DR BioCyc; YEAST:G3O-32372-MON; -.
DR Reactome; R-SCE-3322077; Glycogen synthesis.
DR PRO; PR:Q06216; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; Q06216; protein.
DR GO; GO:0000164; C:protein phosphatase type 1 complex; ISA:SGD.
DR GO; GO:2001069; F:glycogen binding; IBA:GO_Central.
DR GO; GO:0008157; F:protein phosphatase 1 binding; IBA:GO_Central.
DR GO; GO:0019888; F:protein phosphatase regulator activity; IMP:SGD.
DR GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0005979; P:regulation of glycogen biosynthetic process; IGI:SGD.
DR Gene3D; 2.60.40.2440; -; 1.
DR InterPro; IPR005036; CBM21_dom.
DR InterPro; IPR038175; CBM21_dom_sf.
DR Pfam; PF03370; CBM_21; 1.
DR PROSITE; PS51159; CBM21; 1.
PE 1: Evidence at protein level;
KW Glycogen biosynthesis; Reference proteome.
FT CHAIN 1..648
FT /note="Serine/threonine-protein phosphatase 1 regulatory
FT subunit PIG1"
FT /id="PRO_0000071519"
FT DOMAIN 201..331
FT /note="CBM21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00491"
FT REGION 20..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..629
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..615
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 228
FT /note="I -> K (in Ref. 3; AAU09763)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 648 AA; 74146 MW; B95853040B225BD7 CRC64;
MPYSHGKKLK PSLKLAKTIS TSSFVSSTTS NSFSPLEDST SASSSTSSSS SGKSVRFAAH
LYTVKKFNTK LAPISISEKA ASNLTRNLHN NAIPLTFPFI GGEDHRYSLD ILDYSDLEYD
NKDVEYDNES DVEDNAMLMH DRSMFIEKEI LCFGEEETFD MADWKLVSNN LNPFKSDYKV
DVTGLEDKIF KYLNGQNIKV HSLELSDPVS YEDICSNNFG NCQIWGLIFV NNLNFEKKIE
IKFTLNNWAD IHYINAHYNK SVTPHVDEFK FIIDISALKL NLISKNLIYT NFFERKTTCL
LNLQFCCRYD VNGFEYRSFY DNNDYKNYEI TISLSAINLN RAVSNSSIFN SNLGPSKMGA
SNAEVTMSKN NENSKKPLRK FIKDTDYYND SPLKHKFYQS FETKAACKTE PVSQTFKAET
IDCEIEPFNY FFEPPDSQTN EDMSDSSYDL SLQDFNYWEF SNHGLGKALA DSDILQFKNY
PKPEPFSRPP IIDDTFTLNT DDRTLGSKTQ KLEDNLAKEW KSAKTRTTLN ETPLHDDEHR
TSFTYTTWNN STDTLMKRKE ERPVESASCS QLSIATIKAE EDLLYQDYIN SGRESSSPEI
SPLNTTTSLP FFPGDNMSDS SGEYEERTSL SPNKIHIFRD YFYKSPSP
