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PIG20_CLAP2
ID   PIG20_CLAP2             Reviewed;         618 AA.
AC   M1WCE9;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 2.
DT   23-FEB-2022, entry version 21.
DE   RecName: Full=Transcriptional regulator CPUR_05421 {ECO:0000303|PubMed:30996871};
DE   AltName: Full=Ergochrome biosynthesis cluster protein CPUR_05421 {ECO:0000303|PubMed:30996871};
GN   ORFNames=CPUR_05421;
OS   Claviceps purpurea (strain 20.1) (Ergot fungus) (Sphacelia segetum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Claviceps.
OX   NCBI_TaxID=1111077;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=20.1;
RX   PubMed=23468653; DOI=10.1371/journal.pgen.1003323;
RA   Schardl C.L., Young C.A., Hesse U., Amyotte S.G., Andreeva K., Calie P.J.,
RA   Fleetwood D.J., Haws D.C., Moore N., Oeser B., Panaccione D.G.,
RA   Schweri K.K., Voisey C.R., Farman M.L., Jaromczyk J.W., Roe B.A.,
RA   O'Sullivan D.M., Scott B., Tudzynski P., An Z., Arnaoudova E.G.,
RA   Bullock C.T., Charlton N.D., Chen L., Cox M., Dinkins R.D., Florea S.,
RA   Glenn A.E., Gordon A., Gueldener U., Harris D.R., Hollin W., Jaromczyk J.,
RA   Johnson R.D., Khan A.K., Leistner E., Leuchtmann A., Li C., Liu J., Liu J.,
RA   Liu M., Mace W., Machado C., Nagabhyru P., Pan J., Schmid J., Sugawara K.,
RA   Steiner U., Takach J.E., Tanaka E., Webb J.S., Wilson E.V., Wiseman J.L.,
RA   Yoshida R., Zeng Z.;
RT   "Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of the
RT   Clavicipitaceae reveals dynamics of alkaloid loci.";
RL   PLoS Genet. 9:E1003323-E1003323(2013).
RN   [2]
RP   FUNCTION.
RX   PubMed=28955461; DOI=10.1186/s40694-016-0020-z;
RA   Neubauer L., Dopstadt J., Humpf H.U., Tudzynski P.;
RT   "Identification and characterization of the ergochrome gene cluster in the
RT   plant pathogenic fungus Claviceps purpurea.";
RL   Fungal Biol. Biotechnol. 3:2-2(2016).
RN   [3]
RP   IDENTIFICATION, AND FUNCTION.
RX   PubMed=30996871; DOI=10.1039/c8sc05126g;
RA   Greco C., de Mattos-Shipley K., Bailey A.M., Mulholland N.P., Vincent J.L.,
RA   Willis C.L., Cox R.J., Simpson T.J.;
RT   "Structure revision of cryptosporioptides and determination of the genetic
RT   basis for dimeric xanthone biosynthesis in fungi.";
RL   Chem. Sci. 10:2930-2939(2019).
CC   -!- FUNCTION: Transcriptional regulator; part of the ergochrome gene
CC       cluster responsible for the typical purple-black color of the ergot
CC       sclerotia (Probable). The ergochrome gene cluster produces several
CC       ergot pigments including the yellow ergochrome secalonic acid and its
CC       derivatives, as well as the red anthraquinones endocrocin and
CC       clavorubin (PubMed:28955461). {ECO:0000269|PubMed:28955461,
CC       ECO:0000305|PubMed:30996871}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CCE31568.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CAGA01000032; CCE31568.1; ALT_SEQ; Genomic_DNA.
DR   EnsemblFungi; CCE31568; CCE31568; CPUR_05421.
DR   VEuPathDB; FungiDB:CPUR_05421; -.
DR   eggNOG; ENOG502SKTR; Eukaryota.
DR   HOGENOM; CLU_516777_0_0_1; -.
DR   OrthoDB; 483063at2759; -.
DR   PhylomeDB; M1WCE9; -.
DR   Proteomes; UP000016801; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..618
FT                   /note="Transcriptional regulator CPUR_05421"
FT                   /id="PRO_0000453510"
FT   DNA_BIND        14..41
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          52..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..87
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   618 AA;  69659 MW;  B6747697E9B166E3 CRC64;
     MVAPHESQRV ADSCSHLVGR EIGCSRDLAG CRRCTSEGRA CSYSRSGVIH RTRRRNRANQ
     DVTRSALYSS NTTPQTISDQ ATGRPCEGAD NTETAYDRLQ QIIPSRSHQS VRVIAELLEE
     YTEAWQGSEA FEKLSKAPIA EFFVFSEPQT RCWLDNLNLI LEKEELLIFT IPPEVYAQLA
     SSRPQEVQDR SWLVMFYSVA IYVEHSKAQN THRVATLSKL RRNLWLAFND VRLLIEPSPA
     RIQALIILAT YVEEFMTPCV CWSLITKACT MLQALGIVHW RLDTATSDVR AMLFWRLNML
     DKALALILCR APAFHREMSS QIAMPTLNRL MQCRPKRTKD YPPALFEAHY LHQMHLVSCI
     MADVWHALYG QDTEKVQEVK ERLEAWYRQA KEVIEAAALV ERPLLTAKGA AAVDLGRQTL
     RFQYLSLVVL LTVSSRQLRS QSIGPSQEML NLLSALGDAI PDHKGPYACL LWQYLHCPLA
     AFGALWGELV MKTTANPEQS LKSMEAIAHL PLYLGKLGSR HALAARLQSI TARIVEQARM
     IVNSQEAPEA LPVQDEPTNP GLPAPAAEIL PIVAPNESLD PTQMQPVDDF LDDRFIMQSD
     PFFGTTFDWF AWGGNLEV
 
 
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