ID   PIGC_BOVIN              Reviewed;         297 AA.
AC   Q3ZBX1;
DT   03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Phosphatidylinositol N-acetylglucosaminyltransferase subunit C {ECO:0000250|UniProtKB:Q92535};
DE   AltName: Full=Phosphatidylinositol-glycan biosynthesis class C protein;
DE            Short=PIG-C;
GN   Name=PIGC {ECO:0000250|UniProtKB:Q92535};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the glycosylphosphatidylinositol-N-
CC       acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the
CC       transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
CC       phosphatidylinositol and participates in the first step of GPI
CC       biosynthesis. {ECO:0000250|UniProtKB:Q92535}.
CC   -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC       biosynthesis. {ECO:0000250|UniProtKB:Q92535}.
CC   -!- SUBUNIT: Component of the glycosylphosphatidylinositol-N-
CC       acetylglucosaminyltransferase (GPI-GnT) complex composed at least by
CC       PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts with PIGQ.
CC       Interacts with the heterodimer PIGA:PIGH.
CC       {ECO:0000250|UniProtKB:Q92535}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q92535}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q92535}.
CC   -!- SIMILARITY: Belongs to the PIGC family. {ECO:0000305}.
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DR   EMBL; BC103058; AAI03059.1; -; mRNA.
DR   RefSeq; NP_001029555.1; NM_001034383.1.
DR   RefSeq; XP_005216956.1; XM_005216899.2.
DR   AlphaFoldDB; Q3ZBX1; -.
DR   STRING; 9913.ENSBTAP00000034036; -.
DR   PaxDb; Q3ZBX1; -.
DR   Ensembl; ENSBTAT00000034135; ENSBTAP00000034036; ENSBTAG00000024542.
DR   GeneID; 510483; -.
DR   KEGG; bta:510483; -.
DR   CTD; 5279; -.
DR   VEuPathDB; HostDB:ENSBTAG00000024542; -.
DR   eggNOG; KOG3059; Eukaryota.
DR   GeneTree; ENSGT00390000005496; -.
DR   HOGENOM; CLU_024002_0_0_1; -.
DR   InParanoid; Q3ZBX1; -.
DR   OMA; HAFVMVT; -.
DR   OrthoDB; 1241278at2759; -.
DR   TreeFam; TF314325; -.
DR   UniPathway; UPA00196; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000024542; Expressed in biceps femoris and 106 other tissues.
DR   GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR009450; Plno_GlcNAc_GPI2.
DR   PANTHER; PTHR12982; PTHR12982; 1.
DR   Pfam; PF06432; GPI2; 1.
DR   PIRSF; PIRSF016104; GPI2; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; GPI-anchor biosynthesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..297
FT                   /note="Phosphatidylinositol N-acetylglucosaminyltransferase
FT                   subunit C"
FT                   /id="PRO_0000365731"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   297 AA;  33628 MW;  A79B4E4B04D8D80B CRC64;
     MCAQPVANTK EVRWQKVLYE RQPFPDNYVD RRFLEELRKN IYARKYQYWA VVFESSVVIQ
     QLCSVCVFVV IWWYMDEGLL APQWLFGTGL ASSLIGYVLF DFIDGGEGRK KSGRTRWADL
     KSALVFITFT YGFSPVLKTL TESVSTDTIY AMAVFMLLGH LIFFDYGANA AIVSSTLSLN
     MAIFASVCLA SRLPRSLHAF IMVTFAIQIF ALWPMLQKKL KACTPRSYVG VTLLFAFSAL
     GGLLSISAVG AILFALLLIS ISCLCPFYLI RLQLFKENIH GPWDEAEIKE DLSRFLS