PIGC_MOUSE
ID PIGC_MOUSE Reviewed; 297 AA.
AC Q9CXR4; Q3U7H3;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Phosphatidylinositol N-acetylglucosaminyltransferase subunit C {ECO:0000305};
DE AltName: Full=Phosphatidylinositol-glycan biosynthesis class C protein;
DE Short=PIG-C;
GN Name=Pigc {ECO:0000312|MGI:MGI:1914542};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, and Embryonic head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Part of the glycosylphosphatidylinositol-N-
CC acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the
CC transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
CC phosphatidylinositol and participates in the first step of GPI
CC biosynthesis. {ECO:0000250|UniProtKB:Q92535}.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000250|UniProtKB:Q92535}.
CC -!- SUBUNIT: Component of the glycosylphosphatidylinositol-N-
CC acetylglucosaminyltransferase (GPI-GnT) complex composed at least by
CC PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts with PIGQ.
CC Interacts with the heterodimer PIGA:PIGH.
CC {ECO:0000250|UniProtKB:Q92535}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000250|UniProtKB:Q92535}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q92535}.
CC -!- SIMILARITY: Belongs to the PIGC family. {ECO:0000305}.
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DR EMBL; AK014096; BAB29152.1; -; mRNA.
DR EMBL; AK152660; BAE31396.1; -; mRNA.
DR EMBL; BC006938; AAH06938.1; -; mRNA.
DR CCDS; CCDS15419.1; -.
DR RefSeq; NP_001034134.1; NM_001039045.1.
DR RefSeq; NP_080354.1; NM_026078.2.
DR RefSeq; XP_006497022.1; XM_006496959.2.
DR AlphaFoldDB; Q9CXR4; -.
DR STRING; 10090.ENSMUSP00000107221; -.
DR PhosphoSitePlus; Q9CXR4; -.
DR PaxDb; Q9CXR4; -.
DR PRIDE; Q9CXR4; -.
DR ProteomicsDB; 288206; -.
DR Antibodypedia; 34384; 88 antibodies from 24 providers.
DR DNASU; 67292; -.
DR Ensembl; ENSMUST00000028021; ENSMUSP00000028021; ENSMUSG00000026698.
DR Ensembl; ENSMUST00000111594; ENSMUSP00000107221; ENSMUSG00000026698.
DR Ensembl; ENSMUST00000193784; ENSMUSP00000141646; ENSMUSG00000026698.
DR GeneID; 67292; -.
DR KEGG; mmu:67292; -.
DR UCSC; uc007dfx.1; mouse.
DR CTD; 5279; -.
DR MGI; MGI:1914542; Pigc.
DR VEuPathDB; HostDB:ENSMUSG00000026698; -.
DR eggNOG; KOG3059; Eukaryota.
DR GeneTree; ENSGT00390000005496; -.
DR HOGENOM; CLU_024002_0_0_1; -.
DR InParanoid; Q9CXR4; -.
DR OMA; HAFVMVT; -.
DR OrthoDB; 1241278at2759; -.
DR PhylomeDB; Q9CXR4; -.
DR TreeFam; TF314325; -.
DR Reactome; R-MMU-162710; Synthesis of glycosylphosphatidylinositol (GPI).
DR UniPathway; UPA00196; -.
DR BioGRID-ORCS; 67292; 7 hits in 73 CRISPR screens.
DR ChiTaRS; Pigc; mouse.
DR PRO; PR:Q9CXR4; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9CXR4; protein.
DR Bgee; ENSMUSG00000026698; Expressed in small intestine Peyer's patch and 234 other tissues.
DR ExpressionAtlas; Q9CXR4; baseline and differential.
DR Genevisible; Q9CXR4; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:MGI.
DR GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR InterPro; IPR009450; Plno_GlcNAc_GPI2.
DR PANTHER; PTHR12982; PTHR12982; 1.
DR Pfam; PF06432; GPI2; 1.
DR PIRSF; PIRSF016104; GPI2; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; GPI-anchor biosynthesis; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..297
FT /note="Phosphatidylinositol N-acetylglucosaminyltransferase
FT subunit C"
FT /id="PRO_0000058432"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 297 AA; 33724 MW; 3116EF0B412E58BC CRC64;
MCAQRVTDTP EVKWQKVLYE RQPFPDNYVD QRFLEELRKN IYARKYQYWA VVFESSVVIQ
QLCSVCVFVV IWWYMDEGLL APQWLFGTGL ASSLVGYVLF DLIDGGDGRK KSGRTRWADL
KSTLVFITFT YGFSPVLKTL TESVSTDTIY AMAVFMLLGH LIFFDYGANA AIVSSTLSLN
MAIFASVCLA SRLPRSLHAF IMVTFAIQIF ALWPMLQKKL KAYTPRSYVG VTLLFAFSAF
GGLLSISAVG AILFALLLFS ISCLCPYYLI HLQLFKENIH GPWDEAEIKE DLSRFLS
