ID   PIGC_RAT                Reviewed;         297 AA.
AC   Q5PQQ4;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Phosphatidylinositol N-acetylglucosaminyltransferase subunit C {ECO:0000305};
DE   AltName: Full=Phosphatidylinositol-glycan biosynthesis class C protein;
DE            Short=PIG-C;
GN   Name=Pigc {ECO:0000312|RGD:1311337};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Part of the glycosylphosphatidylinositol-N-
CC       acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the
CC       transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
CC       phosphatidylinositol and participates in the first step of GPI
CC       biosynthesis. {ECO:0000250|UniProtKB:Q92535}.
CC   -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC       biosynthesis. {ECO:0000250|UniProtKB:Q92535}.
CC   -!- SUBUNIT: Component of the glycosylphosphatidylinositol-N-
CC       acetylglucosaminyltransferase (GPI-GnT) complex composed at least by
CC       PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts with PIGQ.
CC       Interacts with the heterodimer PIGA:PIGH.
CC       {ECO:0000250|UniProtKB:Q92535}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000250|UniProtKB:Q92535}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q92535}.
CC   -!- SIMILARITY: Belongs to the PIGC family. {ECO:0000305}.
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DR   EMBL; BC087080; AAH87080.1; -; mRNA.
DR   RefSeq; NP_001012207.1; NM_001012207.1.
DR   RefSeq; XP_006250244.1; XM_006250182.2.
DR   RefSeq; XP_006250245.1; XM_006250183.2.
DR   RefSeq; XP_008767887.1; XM_008769665.2.
DR   AlphaFoldDB; Q5PQQ4; -.
DR   STRING; 10116.ENSRNOP00000035922; -.
DR   PaxDb; Q5PQQ4; -.
DR   Ensembl; ENSRNOT00000035558; ENSRNOP00000035922; ENSRNOG00000026497.
DR   Ensembl; ENSRNOT00000076417; ENSRNOP00000068091; ENSRNOG00000026497.
DR   Ensembl; ENSRNOT00000077069; ENSRNOP00000068000; ENSRNOG00000026497.
DR   Ensembl; ENSRNOT00000105154; ENSRNOP00000094482; ENSRNOG00000026497.
DR   GeneID; 364032; -.
DR   KEGG; rno:364032; -.
DR   UCSC; RGD:1311337; rat.
DR   CTD; 5279; -.
DR   RGD; 1311337; Pigc.
DR   eggNOG; KOG3059; Eukaryota.
DR   GeneTree; ENSGT00390000005496; -.
DR   HOGENOM; CLU_024002_0_0_1; -.
DR   InParanoid; Q5PQQ4; -.
DR   OMA; HAFVMVT; -.
DR   OrthoDB; 1241278at2759; -.
DR   PhylomeDB; Q5PQQ4; -.
DR   TreeFam; TF314325; -.
DR   Reactome; R-RNO-162710; Synthesis of glycosylphosphatidylinositol (GPI).
DR   UniPathway; UPA00196; -.
DR   PRO; PR:Q5PQQ4; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000026497; Expressed in quadriceps femoris and 19 other tissues.
DR   ExpressionAtlas; Q5PQQ4; baseline and differential.
DR   Genevisible; Q5PQQ4; RN.
DR   GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR009450; Plno_GlcNAc_GPI2.
DR   PANTHER; PTHR12982; PTHR12982; 1.
DR   Pfam; PF06432; GPI2; 1.
DR   PIRSF; PIRSF016104; GPI2; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; GPI-anchor biosynthesis; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..297
FT                   /note="Phosphatidylinositol N-acetylglucosaminyltransferase
FT                   subunit C"
FT                   /id="PRO_0000058433"
FT   TRANSMEM        67..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   297 AA;  33666 MW;  FE914EE878ED8597 CRC64;
     MCAQHVADTS EVKWQKVLYE RQPFPDNYVD QRFLEELRKN IYARKYQYWA VVFESSVVIQ
     QLCSVCVFVV IWWYMDEGLL APQWLFGTGL ASSLVGYVLF DLIDGGDGRK KSGRTRWADL
     KSTLVFITFT YGFSPVLKTL TESVSTDTIY AMSVFMLLGH LIFFDYGANA AIVSSTLSLN
     MAIFASVCLA SRLPRSLHAF IMVTFAIQIF ALWPMLQKKL KAYTPRSYVG VTLLFAFSAF
     GGLLSISGVG AILFALLLFS ISCLCPYYLI HLQLFKENIH GPWDEAEIKE DLSRFLS