PIGE_DROME
ID PIGE_DROME Reviewed; 915 AA.
AC Q24118; Q9VIY7;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein pigeon;
DE AltName: Full=Protein linotte;
GN Name=pigeon; Synonyms=lio; ORFNames=CG10739;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Canton-S; TISSUE=Head;
RX PubMed=7576632; DOI=10.1016/0896-6273(95)90174-4;
RA Bolwig G.M., del Vecchio M., Hannon G., Tully T.;
RT "Molecular cloning of linotte in Drosophila: a novel gene that functions in
RT adults during associative learning.";
RL Neuron 15:829-842(1995).
RN [2]
RP ERRATUM OF PUBMED:7576632.
RA Bolwig G.M., del Vecchio M., Hannon G., Tully T.;
RL Neuron 34:667-667(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- DEVELOPMENTAL STAGE: Detected in embryos, pupae, and adults but not
CC larvae.
CC -!- MISCELLANEOUS: 'Linotte' used in the colloquial sentence 'Tete de
CC linotte' literally means 'Scatterbrain' in French.
CC -!- SIMILARITY: Belongs to the GSAP family. {ECO:0000305}.
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DR EMBL; U32865; AAA92001.1; -; mRNA.
DR EMBL; AE014134; AAF53775.1; -; Genomic_DNA.
DR EMBL; AY061465; AAL29013.1; -; mRNA.
DR RefSeq; NP_476946.1; NM_057598.5.
DR AlphaFoldDB; Q24118; -.
DR BioGRID; 61184; 3.
DR DIP; DIP-18808N; -.
DR STRING; 7227.FBpp0080735; -.
DR PaxDb; Q24118; -.
DR EnsemblMetazoa; FBtr0081194; FBpp0080735; FBgn0010309.
DR GeneID; 35200; -.
DR KEGG; dme:Dmel_CG10739; -.
DR UCSC; CG10739-RA; d. melanogaster.
DR CTD; 35200; -.
DR FlyBase; FBgn0010309; pigeon.
DR VEuPathDB; VectorBase:FBgn0010309; -.
DR eggNOG; ENOG502QWQK; Eukaryota.
DR GeneTree; ENSGT00390000012875; -.
DR HOGENOM; CLU_008601_0_0_1; -.
DR InParanoid; Q24118; -.
DR OMA; CANQSRN; -.
DR PhylomeDB; Q24118; -.
DR BioGRID-ORCS; 35200; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35200; -.
DR PRO; PR:Q24118; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0010309; Expressed in egg chamber and 25 other tissues.
DR ExpressionAtlas; Q24118; baseline and differential.
DR Genevisible; Q24118; DM.
DR GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR GO; GO:1902004; P:positive regulation of amyloid-beta formation; IBA:GO_Central.
DR InterPro; IPR028010; GSAP_C_dom.
DR InterPro; IPR026172; GSAP_fam.
DR PANTHER; PTHR13630; PTHR13630; 1.
DR Pfam; PF14959; GSAP-16; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..915
FT /note="Protein pigeon"
FT /id="PRO_0000058434"
FT CONFLICT 335
FT /note="Y -> C (in Ref. 1; AAA92001)"
FT /evidence="ECO:0000305"
FT CONFLICT 451..452
FT /note="LH -> FD (in Ref. 1; AAA92001)"
FT /evidence="ECO:0000305"
FT CONFLICT 518
FT /note="H -> L (in Ref. 1; AAA92001)"
FT /evidence="ECO:0000305"
FT CONFLICT 867
FT /note="A -> G (in Ref. 1; AAA92001)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 915 AA; 102899 MW; 64768399B546368D CRC64;
MLRQENLAAN FCGLLASQGY KEKANEWRIL GQEQDGSLLT SWIFEYADED QRKETCIGHF
HATKKQLRLL WTLDNCREIV QATINSSVTL LSFVEKTEGK LYQAFVVEVR SSEGGTATPL
NSEPSNRQMM TQFLWRVESA TRTCWQDKLL VLTHEESIKQ YSCVVKQSST TCSTGGGEGS
AWRLDTSILT YETLARNFSW AQWDPECQAL YYIHLKPKAK SLSLLDEREE AGEQTTPTLS
PTLSAFQFNE KQPTETVLNI PLNLPKLPNG SKEESPSYDD DAVPLRVHDS SLNLIILADT
SGMFFVCHYY LYQPMQSEQR DVHFAYSVTL LHHGYVVHCV MPGVPWQKAR LLRPTFALHG
QHHLLVSSAF FVHLLDVGLQ HEPNCHIVCA AHNRSPDITQ LVPLRKWGAL AYDAATLDLV
SLSVPKSHLI EAFRNDSSLD NRISIIHYFL LHSNDMDVLA ELLNNILERP LSLDTVALLK
EALVAGSYAA AVRGLPEDAK PLMRLLPLTT ALASRPIHAK VADISVGLSH ETLHNTSMML
LSPQQRLSPY RTDIWTRLWD LLNESAKQEQ PRFSAEQVTE KLIFSLACYQ PEALSRCTTP
LSPDTGTGGF GDYSSGSAFP FSNEVLPFIE LEGCTASKQE HVISVYLREL SVHLVKHTSK
PNTGFRWLKE TFFERSQAPA HVHAVASQFV SAQLELSRAL CSLVCRAAGL DARMETSRGF
QLIDQMAANQ QHSLFLILER YCLAVESIAF PLPEGFSSFF TYLGYRALGY DMFLQYVENH
VFELQVDVMK AIVFDIEDSP LGIERKLSLL SALPKQRAQR LLKCWQHPDS LMIRGREHAA
NILSGQQQEV LHQQRPTACV NQSRNNARSD LTAEALSPLD SFLDLLTAKA SLNELDYNLL
IETTLSSIDQ LKLEA
