ID   PIGH_BOVIN              Reviewed;         188 AA.
AC   Q32L89;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Phosphatidylinositol N-acetylglucosaminyltransferase subunit H {ECO:0000250|UniProtKB:Q14442};
DE   AltName: Full=Phosphatidylinositol-glycan biosynthesis class H protein;
DE            Short=PIG-H;
GN   Name=PIGH {ECO:0000250|UniProtKB:Q14442};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the glycosylphosphatidylinositol-N-
CC       acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the
CC       transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
CC       phosphatidylinositol and participates in the first step of GPI
CC       biosynthesis. {ECO:0000250|UniProtKB:Q14442}.
CC   -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC       biosynthesis. {ECO:0000250|UniProtKB:Q14442}.
CC   -!- SUBUNIT: Component of the glycosylphosphatidylinositol-N-
CC       acetylglucosaminyltransferase (GPI-GnT) complex composed at least by
CC       PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts with PIGQ.
CC       {ECO:0000250|UniProtKB:Q14442}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PIGH family. {ECO:0000305}.
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DR   EMBL; BC109701; AAI09702.1; -; mRNA.
DR   RefSeq; NP_001033205.2; NM_001038116.2.
DR   AlphaFoldDB; Q32L89; -.
DR   STRING; 9913.ENSBTAP00000024352; -.
DR   PaxDb; Q32L89; -.
DR   GeneID; 515306; -.
DR   KEGG; bta:515306; -.
DR   CTD; 5283; -.
DR   eggNOG; KOG4551; Eukaryota.
DR   InParanoid; Q32L89; -.
DR   OrthoDB; 1431299at2759; -.
DR   UniPathway; UPA00196; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; ISS:UniProtKB.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR019328; GPI-GlcNAc_Trfase_PIG-H_dom.
DR   InterPro; IPR044215; PIG-H.
DR   PANTHER; PTHR15231; PTHR15231; 1.
DR   Pfam; PF10181; PIG-H; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..188
FT                   /note="Phosphatidylinositol N-acetylglucosaminyltransferase
FT                   subunit H"
FT                   /id="PRO_0000281861"
SQ   SEQUENCE   188 AA;  21006 MW;  E450717E79AB0E48 CRC64;
     MEDERSLSDI CGGRLALHRR YYSPSCLEFC LSCPRISLRS ITAVTCTVWL AAYGLFTLCE
     NSMILSAAIF ITLLGLLGYL HFVKIDHETL LIIDSLGIQM TSSYASGKES TTFIEMGKVK
     DVIINEAIYM QKVIYYLCIL LKDPVEPHGI SQVVPIFQSA KPRLDCLIEV YRSCQEILAH
     QKAASTSP