PIGH_MOUSE
ID PIGH_MOUSE Reviewed; 188 AA.
AC Q5M9N4;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Phosphatidylinositol N-acetylglucosaminyltransferase subunit H {ECO:0000305};
DE AltName: Full=Phosphatidylinositol-glycan biosynthesis class H protein;
DE Short=PIG-H;
GN Name=Pigh {ECO:0000312|MGI:MGI:99463};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=DBA/2J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Part of the glycosylphosphatidylinositol-N-
CC acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the
CC transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
CC phosphatidylinositol and participates in the first step of GPI
CC biosynthesis. {ECO:0000250|UniProtKB:Q14442}.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000250|UniProtKB:Q14442}.
CC -!- SUBUNIT: Component of the glycosylphosphatidylinositol-N-
CC acetylglucosaminyltransferase (GPI-GnT) complex composed at least by
CC PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts with PIGQ.
CC {ECO:0000250|UniProtKB:Q14442}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PIGH family. {ECO:0000305}.
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DR EMBL; AK167892; BAE39904.1; -; mRNA.
DR EMBL; BC086806; AAH86806.1; -; mRNA.
DR CCDS; CCDS26006.1; -.
DR RefSeq; NP_084264.1; NM_029988.2.
DR AlphaFoldDB; Q5M9N4; -.
DR STRING; 10090.ENSMUSP00000072018; -.
DR PhosphoSitePlus; Q5M9N4; -.
DR EPD; Q5M9N4; -.
DR MaxQB; Q5M9N4; -.
DR PaxDb; Q5M9N4; -.
DR PRIDE; Q5M9N4; -.
DR ProteomicsDB; 288207; -.
DR Antibodypedia; 24854; 153 antibodies from 23 providers.
DR DNASU; 110417; -.
DR Ensembl; ENSMUST00000072154; ENSMUSP00000072018; ENSMUSG00000021120.
DR GeneID; 110417; -.
DR KEGG; mmu:110417; -.
DR UCSC; uc007nzs.2; mouse.
DR CTD; 5283; -.
DR MGI; MGI:99463; Pigh.
DR VEuPathDB; HostDB:ENSMUSG00000021120; -.
DR eggNOG; KOG4551; Eukaryota.
DR GeneTree; ENSGT00390000011890; -.
DR HOGENOM; CLU_102225_1_0_1; -.
DR InParanoid; Q5M9N4; -.
DR OMA; FVKIDHE; -.
DR OrthoDB; 1431299at2759; -.
DR PhylomeDB; Q5M9N4; -.
DR TreeFam; TF324479; -.
DR Reactome; R-MMU-162710; Synthesis of glycosylphosphatidylinositol (GPI).
DR UniPathway; UPA00196; -.
DR BioGRID-ORCS; 110417; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q5M9N4; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q5M9N4; protein.
DR Bgee; ENSMUSG00000021120; Expressed in paneth cell and 239 other tissues.
DR ExpressionAtlas; Q5M9N4; baseline and differential.
DR Genevisible; Q5M9N4; MM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; ISO:MGI.
DR GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; ISS:UniProtKB.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR InterPro; IPR019328; GPI-GlcNAc_Trfase_PIG-H_dom.
DR InterPro; IPR044215; PIG-H.
DR PANTHER; PTHR15231; PTHR15231; 1.
DR Pfam; PF10181; PIG-H; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..188
FT /note="Phosphatidylinositol N-acetylglucosaminyltransferase
FT subunit H"
FT /id="PRO_0000281862"
SQ SEQUENCE 188 AA; 21078 MW; C4C202F84A741A99 CRC64;
MEDEKSFSDI CGGRLALRCR YYSPYCREFG LSSARLSLCS LTAVTCAVWL AAYGLFTLCE
NSMVLSATIF ITILGLLGYL HFVKIDQETL LIIDSLGIQM TSSYASGKES TTFIEMDKVK
DIIINEAIYM QKVIYYLCIL LKEPGKPHEI SRVVPVFQSA KPRLDCLIEV YRSCQEVLAH
QKATATSL
