PIGM_CHICK
ID PIGM_CHICK Reviewed; 418 AA.
AC Q5F380;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=GPI mannosyltransferase 1;
DE EC=2.4.1.-;
DE AltName: Full=GPI mannosyltransferase I;
DE Short=GPI-MT-I;
DE AltName: Full=Phosphatidylinositol-glycan biosynthesis class M protein;
DE Short=PIG-M;
GN Name=PIGM; ORFNames=RCJMB04_29i7;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-
CC anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-
CC acyl-PI during GPI precursor assembly (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PIGM family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAH65404.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AJ851770; CAH65404.1; ALT_INIT; mRNA.
DR RefSeq; NP_001026693.2; NM_001031522.2.
DR AlphaFoldDB; Q5F380; -.
DR STRING; 9031.ENSGALP00000037081; -.
DR CAZy; GT50; Glycosyltransferase Family 50.
DR PaxDb; Q5F380; -.
DR GeneID; 428583; -.
DR KEGG; gga:428583; -.
DR CTD; 93183; -.
DR VEuPathDB; HostDB:geneid_428583; -.
DR eggNOG; KOG3893; Eukaryota.
DR InParanoid; Q5F380; -.
DR OrthoDB; 1003258at2759; -.
DR PhylomeDB; Q5F380; -.
DR UniPathway; UPA00196; -.
DR PRO; PR:Q5F380; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1990529; C:glycosylphosphatidylinositol-mannosyltransferase I complex; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051751; F:alpha-1,4-mannosyltransferase activity; IEA:InterPro.
DR GO; GO:0004376; F:glycolipid mannosyltransferase activity; IEA:InterPro.
DR GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR InterPro; IPR007704; PIG-M.
DR PANTHER; PTHR12886; PTHR12886; 1.
DR Pfam; PF05007; Mannosyl_trans; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycosyltransferase; GPI-anchor biosynthesis;
KW Membrane; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..418
FT /note="GPI mannosyltransferase 1"
FT /id="PRO_0000246218"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 28..79
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 101..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..220
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 242..281
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 303..323
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 345..351
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 373..378
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 400..418
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 418 AA; 46577 MW; 08A704FB8CEF2C6F CRC64;
MAGGRPGLRA ALGAGLLARL SLVLYGLYQD AVMRVRYTDV DYRVFTDAAR LVTQGRSPYR
RATFRYTPLL AWLLTPNVHL GELFGKLLFV AGDLAAAGVA YRALRRRGAS PGRACGCCAA
AWLLNPLPMA VSSRGNAEAL VAVLVLAALH LVEAGSVGRA ALCYGLAVHL KIYPLTYALP
IALRLQGSGE GAAGAGRDGT AEFTLVGGIW RRVVRVLNRN VLLFGAVAGS VLAALTVLFY
HLYGWEFLEH AYLYHLTRRD IRHNFSPYFY MLYLTAESKW SFALGLAAFL PQLLLLLVVS
VAFYKDLFFC CFLHTAIFVS FNKVCTSQYF IWYLCLLPII IPNIKMSWRR GVLLLFLWFA
GQGLWLAPAY LLEFKGYNTF VFIWSAGLLF LFINSFILVQ IISHYQQETQ VARKVKEQ
