PIGM_DANRE
ID PIGM_DANRE Reviewed; 392 AA.
AC Q7T310;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=GPI mannosyltransferase 1;
DE EC=2.4.1.-;
DE AltName: Full=GPI mannosyltransferase I;
DE Short=GPI-MT-I;
DE AltName: Full=Phosphatidylinositol-glycan biosynthesis class M protein;
DE Short=PIG-M;
GN Name=pigm; ORFNames=zgc:64177;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-
CC anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-
CC acyl-PI during GPI precursor assembly (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PIGM family. {ECO:0000305}.
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DR EMBL; BC053299; AAH53299.1; -; mRNA.
DR RefSeq; NP_956684.1; NM_200390.1.
DR AlphaFoldDB; Q7T310; -.
DR STRING; 7955.ENSDARP00000036819; -.
DR CAZy; GT50; Glycosyltransferase Family 50.
DR PaxDb; Q7T310; -.
DR Ensembl; ENSDART00000032722; ENSDARP00000036819; ENSDARG00000024277.
DR GeneID; 393361; -.
DR KEGG; dre:393361; -.
DR CTD; 93183; -.
DR ZFIN; ZDB-GENE-040426-1393; pigm.
DR eggNOG; KOG3893; Eukaryota.
DR GeneTree; ENSGT00390000017728; -.
DR HOGENOM; CLU_024220_3_1_1; -.
DR InParanoid; Q7T310; -.
DR OMA; VTSQYFI; -.
DR OrthoDB; 1003258at2759; -.
DR PhylomeDB; Q7T310; -.
DR TreeFam; TF314752; -.
DR Reactome; R-DRE-162710; Synthesis of glycosylphosphatidylinositol (GPI).
DR UniPathway; UPA00196; -.
DR PRO; PR:Q7T310; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 24.
DR Bgee; ENSDARG00000024277; Expressed in early embryo and 21 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1990529; C:glycosylphosphatidylinositol-mannosyltransferase I complex; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051751; F:alpha-1,4-mannosyltransferase activity; IEA:InterPro.
DR GO; GO:0004376; F:glycolipid mannosyltransferase activity; IEA:InterPro.
DR GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR InterPro; IPR007704; PIG-M.
DR PANTHER; PTHR12886; PTHR12886; 1.
DR Pfam; PF05007; Mannosyl_trans; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycosyltransferase; GPI-anchor biosynthesis;
KW Membrane; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..392
FT /note="GPI mannosyltransferase 1"
FT /id="PRO_0000246219"
FT TOPO_DOM 1..4
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 26..65
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..125
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..156
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..177
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 178..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..261
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 283..302
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 324..330
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 352..360
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 382..392
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 392 AA; 44409 MW; 189C1A8615AA79B9 CRC64;
MEARVCVLFG AAALLRLLLL CVGVYQDQTL KLKYTDVDYH VFTDAARFIT QGESPYRRST
FRYTPLLALL LVPNVYLSLL FGKLLFGFCD LLSGLLMFRL LVLRGASHGS ACVSCGLWLL
NPLPMAVSTR GNAESVLAVL VLSTLLCLQL RKHTTAALLF GLSVHMKIYP VTYALPIALA
LTAAPARGRG VLLRFFSPAL LRFAAVSAAV FLSLGLIFYC RYGWEFLQEA YLYHLTRRDL
RHNFSPFFYL QYVCAERCWS SGLLPLLLLP QLLLLLLASA AFSSDLPFCC FLHTAVFVSF
NRVCTSQYFL WYLCLLPVVL PRLRLRLGRG LLLLLLWLLL QGLWLAPAYL LEFQGWNSFS
WIWAASLLFL LTNTFILAQI IQHYRPHDRK AD
