PIGM_XENTR
ID PIGM_XENTR Reviewed; 419 AA.
AC Q66IJ4;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 90.
DE RecName: Full=GPI mannosyltransferase 1;
DE EC=2.4.1.-;
DE AltName: Full=GPI mannosyltransferase I;
DE Short=GPI-MT-I;
DE AltName: Full=Phosphatidylinositol-glycan biosynthesis class M protein;
DE Short=PIG-M;
GN Name=pigm; ORFNames=TGas014d02.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mannosyltransferase involved in glycosylphosphatidylinositol-
CC anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-
CC acyl-PI during GPI precursor assembly (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PIGM family. {ECO:0000305}.
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DR EMBL; CR760728; CAJ83771.1; -; mRNA.
DR EMBL; BC081324; AAH81324.1; -; mRNA.
DR RefSeq; NP_001008120.1; NM_001008119.1.
DR AlphaFoldDB; Q66IJ4; -.
DR STRING; 8364.ENSXETP00000013605; -.
DR CAZy; GT50; Glycosyltransferase Family 50.
DR PaxDb; Q66IJ4; -.
DR DNASU; 493482; -.
DR GeneID; 493482; -.
DR KEGG; xtr:493482; -.
DR CTD; 93183; -.
DR Xenbase; XB-GENE-5730241; pigm.
DR eggNOG; KOG3893; Eukaryota.
DR HOGENOM; CLU_024220_3_1_1; -.
DR InParanoid; Q66IJ4; -.
DR OMA; HESFIYH; -.
DR OrthoDB; 1003258at2759; -.
DR PhylomeDB; Q66IJ4; -.
DR TreeFam; TF314752; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000008143; Chromosome 6.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000006188; Expressed in testis and 17 other tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:1990529; C:glycosylphosphatidylinositol-mannosyltransferase I complex; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051751; F:alpha-1,4-mannosyltransferase activity; IEA:InterPro.
DR GO; GO:0004376; F:glycolipid mannosyltransferase activity; IEA:InterPro.
DR GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IBA:GO_Central.
DR InterPro; IPR007704; PIG-M.
DR PANTHER; PTHR12886; PTHR12886; 1.
DR Pfam; PF05007; Mannosyl_trans; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Glycosyltransferase; GPI-anchor biosynthesis;
KW Membrane; Reference proteome; Transferase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..419
FT /note="GPI mannosyltransferase 1"
FT /id="PRO_0000246220"
FT TOPO_DOM 1..13
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 35..88
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 89..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..114
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..168
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 190..224
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 246..285
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..327
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 328..348
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 349..355
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 377..382
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 383..403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 404..419
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 419 AA; 49036 MW; ECBD805202269343 CRC64;
MMKQAGILKI FLQHQFMFPT AFFLRSALVL FGVYQDQTML VKYTDVDYHV FTDAAEYLTQ
GVSPYKRATY RYTPLLAWIL TPNIYVTELY GKMLFVCCDL LAAYLIHRIL VDRGIKDSAS
LYCAIWLFNP LPMVVSSRGN AESVLAVLVL SVLYYVQKRR LIKGALIYGL SVHMKIYPIT
YILPIALFFQ KEDFYGSQEG KRVVSNLKYI RIFRNLLQRL LSRDILLFVT VSGVTFALLT
LFFYYRYGWE FLENTYLYHL TRRDIRHNFS PYFYMLYLTA ENNNSFILGL AAFFPQLVLL
FVVSLAYFKD LPFCCFLHTA IFVSFNKVCT SQYFLWYLCL LPLVMPGLKM SMTNGICLII
LWFFSQAIWL VPAYFLEFEG QNTFLYIWCA GLLFLLINTV IIVQIISNYQ LQSKKTKKT
