ID   PIGP_PONAB              Reviewed;         134 AA.
AC   Q5R946; Q5RA98;
DT   26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Phosphatidylinositol N-acetylglucosaminyltransferase subunit P {ECO:0000250|UniProtKB:P57054};
DE   AltName: Full=Phosphatidylinositol-glycan biosynthesis class P protein;
DE            Short=PIG-P;
GN   Name=PIGP {ECO:0000250|UniProtKB:P57054}; Synonyms=DSCR5;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the glycosylphosphatidylinositol-N-
CC       acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the
CC       transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to
CC       phosphatidylinositol and participates in the first step of GPI
CC       biosynthesis. {ECO:0000250|UniProtKB:P57054}.
CC   -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC       biosynthesis. {ECO:0000250|UniProtKB:P57054}.
CC   -!- SUBUNIT: Component of the glycosylphosphatidylinositol-N-
CC       acetylglucosaminyltransferase (GPI-GnT) complex composed at least by
CC       PIGA, PIGC, PIGH, PIGP, PIGQ, PIGY and DPM2. Interacts directly with
CC       PIGA and PIGQ. {ECO:0000250|UniProtKB:P57054}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the PIGP family. {ECO:0000305}.
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DR   EMBL; CR859549; CAH91714.1; -; mRNA.
DR   EMBL; CR859120; CAH91312.1; -; mRNA.
DR   RefSeq; NP_001127401.1; NM_001133929.1.
DR   AlphaFoldDB; Q5R946; -.
DR   STRING; 9601.ENSPPYP00000012734; -.
DR   GeneID; 100174471; -.
DR   KEGG; pon:100174471; -.
DR   CTD; 51227; -.
DR   eggNOG; KOG2257; Eukaryota.
DR   InParanoid; Q5R946; -.
DR   OrthoDB; 1579862at2759; -.
DR   UniPathway; UPA00196; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0017176; F:phosphatidylinositol N-acetylglucosaminyltransferase activity; IEA:InterPro.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; ISS:UniProtKB.
DR   InterPro; IPR013717; PIG-P.
DR   InterPro; IPR016542; PIG-P_GPI19.
DR   Pfam; PF08510; PIG-P; 1.
DR   PIRSF; PIRSF008765; PIG-P_GPI19; 1.
PE   2: Evidence at transcript level;
KW   Glycosyltransferase; GPI-anchor biosynthesis; Membrane; Reference proteome;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..134
FT                   /note="Phosphatidylinositol N-acetylglucosaminyltransferase
FT                   subunit P"
FT                   /id="PRO_0000191785"
FT   TRANSMEM        13..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        73
FT                   /note="L -> S (in Ref. 1; CAH91312)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        99
FT                   /note="R -> Q (in Ref. 1; CAH91312)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   134 AA;  15465 MW;  1B47322D5B4C2D26 CRC64;
     MVENSPSPLP ERAIYGFVLF LSSQFGFILY LVWAFIPESW LNSLGLTYWP QKYWAVALPV
     YLLIAIVIGY VLLFGINMMS TSPLDSIHTI TDNYARNQRQ KKYQEEAIPA LRDISISEVN
     QMFFLAAKEL YTEN