ID   PIHD1_DANRE             Reviewed;         287 AA.
AC   Q1RM55; A1L208; Q0V938; Q4V8T6; Q5XJL7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=PIH1 domain-containing protein 1;
GN   Name=pih1d1; ORFNames=im:7150545;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye, and Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the assembly of C/D box small nucleolar
CC       ribonucleoprotein (snoRNP) particles (By similarity). Recruits the
CC       SWI/SNF complex to the core promoter of rRNA genes and enhances pre-
CC       rRNA transcription (By similarity). Mediates interaction of TELO2 with
CC       the R2TP complex which is necessary for the stability of MTOR and SMG1
CC       (By similarity). Positively regulates the assembly and activity of the
CC       mTORC1 complex (By similarity). {ECO:0000250|UniProtKB:Q9NWS0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9CQJ2}.
CC   -!- SIMILARITY: Belongs to the PIH1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH97205.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAI15131.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAI21771.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAI29298.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC083282; AAH83282.1; -; mRNA.
DR   EMBL; BC097205; AAH97205.1; ALT_INIT; mRNA.
DR   EMBL; BC115130; AAI15131.1; ALT_INIT; mRNA.
DR   EMBL; BC121770; AAI21771.1; ALT_INIT; mRNA.
DR   EMBL; BC129297; AAI29298.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q1RM55; -.
DR   SMR; Q1RM55; -.
DR   STRING; 7955.ENSDARP00000055307; -.
DR   PaxDb; Q1RM55; -.
DR   ZFIN; ZDB-GENE-050309-147; pih1d1.
DR   eggNOG; KOG4356; Eukaryota.
DR   InParanoid; Q1RM55; -.
DR   PhylomeDB; Q1RM55; -.
DR   PRO; PR:Q1RM55; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0097255; C:R2TP complex; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; IMP:ZFIN.
DR   GO; GO:0000492; P:box C/D snoRNP assembly; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR   InterPro; IPR012981; PIH1_N.
DR   InterPro; IPR041442; PIH1D1/2/3_CS-like.
DR   Pfam; PF08190; PIH1; 1.
DR   Pfam; PF18201; PIH1_CS; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..287
FT                   /note="PIH1 domain-containing protein 1"
FT                   /id="PRO_0000307331"
FT   CONFLICT        5
FT                   /note="A -> S (in Ref. 1; AAI21771)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        50
FT                   /note="C -> S (in Ref. 1; AAI29298)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        77
FT                   /note="H -> Q (in Ref. 1; AAH83282)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        81
FT                   /note="E -> D (in Ref. 1; AAH97205/AAI15131/AAI29298)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        154
FT                   /note="L -> Q (in Ref. 1; AAI21771)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        193
FT                   /note="S -> P (in Ref. 1; AAH97205)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        202
FT                   /note="R -> C (in Ref. 1; AAI21771/AAH83282)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        213
FT                   /note="S -> N (in Ref. 1; AAI21771)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        266
FT                   /note="N -> S (in Ref. 1; AAI21771)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   287 AA;  32030 MW;  B34E7D404D9809B9 CRC64;
     MDTDASLLLG VEHEQKQQEE LYQQLLLQTM GKLQSDSPPS KVIRPQPGLC VKTSSVSDKK
     KVFLNICQSQ TVPPPPHLSQ EALVELLESE DPTSYRVPMS LGEPHTEVDN SSQGCTVYDV
     VINDEFFQKC EKDTLFQQFL IAVSLEGLEN KYSLELSRDI KILKNRKFMG SIAEQNIRTK
     SKPIIQEIDS KESLTLPSAA KRPEFTLLVE PPSGKAEHLI AEILLPGVSS ARSLVLDLGE
     DRLVLIARPS LFHLDIFFPV LIDQENSVAQ YNTNTQTLTV TMPVVSL