ID   PIHD1_XENLA             Reviewed;         297 AA.
AC   Q7ZWY2;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=PIH1 domain-containing protein 1;
GN   Name=pih1d1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo, and Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the assembly of C/D box small nucleolar
CC       ribonucleoprotein (snoRNP) particles (By similarity). Recruits the
CC       SWI/SNF complex to the core promoter of rRNA genes and enhances pre-
CC       rRNA transcription (By similarity). Mediates interaction of TELO2 with
CC       the R2TP complex which is necessary for the stability of MTOR and SMG1
CC       (By similarity). Positively regulates the assembly and activity of the
CC       mTORC1 complex (By similarity). {ECO:0000250|UniProtKB:Q9NWS0}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9CQJ2}.
CC   -!- SIMILARITY: Belongs to the PIH1 family. {ECO:0000305}.
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DR   EMBL; BC046655; AAH46655.1; -; mRNA.
DR   EMBL; BC106293; AAI06294.1; -; mRNA.
DR   RefSeq; NP_001079638.1; NM_001086169.1.
DR   AlphaFoldDB; Q7ZWY2; -.
DR   SMR; Q7ZWY2; -.
DR   BioGRID; 97568; 2.
DR   IntAct; Q7ZWY2; 1.
DR   DNASU; 379325; -.
DR   GeneID; 379325; -.
DR   KEGG; xla:379325; -.
DR   CTD; 379325; -.
DR   Xenbase; XB-GENE-1013261; pih1d1.L.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 379325; Expressed in oocyte and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   InterPro; IPR012981; PIH1_N.
DR   InterPro; IPR041442; PIH1D1/2/3_CS-like.
DR   Pfam; PF08190; PIH1; 1.
DR   Pfam; PF18201; PIH1_CS; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..297
FT                   /note="PIH1 domain-containing protein 1"
FT                   /id="PRO_0000307332"
SQ   SEQUENCE   297 AA;  33656 MW;  FD17E16D9BFC7C28 CRC64;
     MESDKSLLSA ELNSEFEQAL YEQMLLKAKQ EMQNRLPNTP ESKQIRPQPG FCIKTQTSEK
     AKIFINICKT NDIPAPPDLS EAELVNILES DDPSGYRVPM SIGEPHVEVD NSGNGCTVYD
     IVINSTFFDK MKSNELFREF FITVAMEGLE NKYEMELSRD WRMLKNRKFM GSISDQNIRT
     KSKPIIQELD TSSSQTLQSK PLISEIQSSP KVPEYTIAAE PSEGHPSFLV AEISLPNVTS
     VRSLVLDLGE DRIVLWGRPD LYHLDIFLPY NIVQEESGAQ FNRDTKVLTI TMPVQTI