PIHD2_MOUSE
ID PIHD2_MOUSE Reviewed; 315 AA.
AC Q8CHR9; Q05CZ6; Q9CSM2;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=PIH1 domain-containing protein 2;
GN Name=Pih1d2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor, and Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-310 (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CHR9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CHR9-2; Sequence=VSP_028718, VSP_028719;
CC -!- SIMILARITY: Belongs to the PIH1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH19481.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
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DR EMBL; BC019481; AAH19481.1; ALT_SEQ; mRNA.
DR EMBL; BC039645; AAH39645.1; -; mRNA.
DR EMBL; AK012458; BAB28253.1; -; mRNA.
DR CCDS; CCDS23167.1; -. [Q8CHR9-1]
DR RefSeq; NP_082576.1; NM_028300.2. [Q8CHR9-1]
DR AlphaFoldDB; Q8CHR9; -.
DR SMR; Q8CHR9; -.
DR STRING; 10090.ENSMUSP00000000171; -.
DR iPTMnet; Q8CHR9; -.
DR PhosphoSitePlus; Q8CHR9; -.
DR PaxDb; Q8CHR9; -.
DR PRIDE; Q8CHR9; -.
DR ProteomicsDB; 287728; -. [Q8CHR9-1]
DR ProteomicsDB; 287729; -. [Q8CHR9-2]
DR Antibodypedia; 51744; 163 antibodies from 16 providers.
DR DNASU; 72614; -.
DR Ensembl; ENSMUST00000000171; ENSMUSP00000000171; ENSMUSG00000000167. [Q8CHR9-1]
DR Ensembl; ENSMUST00000132187; ENSMUSP00000118064; ENSMUSG00000000167. [Q8CHR9-2]
DR GeneID; 72614; -.
DR KEGG; mmu:72614; -.
DR UCSC; uc009pjz.2; mouse. [Q8CHR9-1]
DR CTD; 120379; -.
DR MGI; MGI:1919864; Pih1d2.
DR VEuPathDB; HostDB:ENSMUSG00000000167; -.
DR eggNOG; KOG4356; Eukaryota.
DR GeneTree; ENSGT00510000048581; -.
DR HOGENOM; CLU_075974_0_0_1; -.
DR InParanoid; Q8CHR9; -.
DR OMA; PEPQFCL; -.
DR OrthoDB; 1394603at2759; -.
DR PhylomeDB; Q8CHR9; -.
DR TreeFam; TF324376; -.
DR BioGRID-ORCS; 72614; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q8CHR9; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q8CHR9; protein.
DR Bgee; ENSMUSG00000000167; Expressed in spermatocyte and 100 other tissues.
DR ExpressionAtlas; Q8CHR9; baseline and differential.
DR Genevisible; Q8CHR9; MM.
DR GO; GO:0101031; C:chaperone complex; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0097255; C:R2TP complex; IBA:GO_Central.
DR GO; GO:1990904; C:ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; ISO:MGI.
DR GO; GO:0000492; P:box C/D snoRNP assembly; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IBA:GO_Central.
DR InterPro; IPR012981; PIH1_N.
DR InterPro; IPR041442; PIH1D1/2/3_CS-like.
DR Pfam; PF08190; PIH1; 1.
DR Pfam; PF18201; PIH1_CS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..315
FT /note="PIH1 domain-containing protein 2"
FT /id="PRO_0000307335"
FT VAR_SEQ 88..114
FT /note="VSVGRPEDSAEASDAYTIIDVAYNPGV -> MLIPSLMLPTILVFCKRQKKT
FT KGSKIS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028718"
FT VAR_SEQ 115..315
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028719"
SQ SEQUENCE 315 AA; 35583 MW; BA7D05E04430ACEE CRC64;
MTVSSKGLLT HISQFWNMLD DLAENDPERY RNFIQQELKD GKQLCVNPEP QLCIQTKILK
PNEKVLFINL CQWERIPAPQ SATRPVPVSV GRPEDSAEAS DAYTIIDVAY NPGVLQAAEK
DQGIKDQLIR MAMLCIEERL QFTLAHSYHL TSFRLKGSIQ RMKESLMGIK TDFPDLKAMT
RTENTLARIR SSTVSEPNHL PEVLLTKKQA SAKGRCLIEE ISSSEIQVEV KKPAYELKVV
KDRNEKPLKI ELKVELPGIK SVSLCELSVS EVDILIEVSE MYRLCLNLPE SINTEMTTAK
FVKNKSALII TMPLA
