ID   PIK2_ORYSJ              Reviewed;        1021 AA.
AC   P0DO07; B5UBC0;
DT   18-JUL-2018, integrated into UniProtKB/Swiss-Prot.
DT   18-JUL-2018, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Disease resistance protein Pik-2 {ECO:0000305};
DE   AltName: Full=Pik-2 blast resistance protein {ECO:0000312|EMBL:ADZ48538.1};
GN   Name=PIK-2 {ECO:0000312|EMBL:ADZ48538.1};
GN   Synonyms=PIK2-KA {ECO:0000312|EMBL:BAL63006.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=cv. Kusabue;
RX   PubMed=21118257; DOI=10.1111/j.1469-8137.2010.03462.x;
RA   Zhai C., Lin F., Dong Z., He X., Yuan B., Zeng X., Wang L., Pan Q.;
RT   "The isolation and characterization of Pik, a rice blast resistance gene
RT   which emerged after rice domestication.";
RL   New Phytol. 189:321-334(2011).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=cv. Kanto 51;
RX   DOI=10.1007/s11032-011-9638-y;
RA   Ashikawa I., Hayashi N., Abe F., Wu J., Matsumoto T.;
RT   "Characterization of the rice blast resistance gene Pik cloned from
RT   Kanto51.";
RL   Mol. Breed. 30:485-494(2012).
CC   -!- FUNCTION: Disease resistance (R) protein. Resistance proteins guard the
CC       plant against pathogens that contain an appropriate avirulence protein
CC       via an indirect interaction with this avirulence protein. That triggers
CC       a defense system including the hypersensitive response, which restricts
CC       the pathogen growth. Contribution of Pik-1 is required to recognize the
CC       effector avirulence protein AVR-Pik. {ECO:0000269|PubMed:21118257,
CC       ECO:0000269|Ref.2}.
CC   -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC       {ECO:0000305}.
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DR   EMBL; HM048900; ADZ48538.1; -; Genomic_DNA.
DR   EMBL; AB616659; BAL63006.1; -; Genomic_DNA.
DR   AlphaFoldDB; P0DO07; -.
DR   SMR; P0DO07; -.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IMP:UniProtKB.
DR   GO; GO:0002758; P:innate immune response-activating signal transduction; IMP:UniProtKB.
DR   GO; GO:0009626; P:plant-type hypersensitive response; IMP:UniProtKB.
DR   CDD; cd14798; RX-CC_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.8.430; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR038005; RX-like_CC.
DR   InterPro; IPR041118; Rx_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23155; PTHR23155; 1.
DR   Pfam; PF00931; NB-ARC; 2.
DR   Pfam; PF18052; Rx_N; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Leucine-rich repeat; Nucleotide-binding;
KW   Plant defense; Repeat.
FT   CHAIN           1..1021
FT                   /note="Disease resistance protein Pik-2"
FT                   /id="PRO_0000444664"
FT   DOMAIN          186..519
FT                   /note="NB-ARC"
FT                   /evidence="ECO:0000255"
FT   REPEAT          612..634
FT                   /note="LRR 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          659..682
FT                   /note="LRR 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          683..705
FT                   /note="LRR 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          785..807
FT                   /note="LRR 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          817..841
FT                   /note="LRR 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          843..865
FT                   /note="LRR 6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          866..888
FT                   /note="LRR 7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          912..935
FT                   /note="LRR 8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          957..981
FT                   /note="LRR 9"
FT                   /evidence="ECO:0000255"
FT   REGION          1..182
FT                   /note="Structured coiled coil (CC) domain"
FT                   /evidence="ECO:0000303|PubMed:21118257"
FT   REGION          297..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          719..751
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1021 AA;  114572 MW;  17AE9413203B49B8 CRC64;
     MELVVGASEA TMKSLLGKLG NLLAQEYALI SGIRGDIQYI NDELASMQAF LRDLSNVPEG
     HSHGHRMKDW MKQIRDIAYD VEDCIDDFAH RLPQDSISDA KWSFLLTKIY ELWTWWPRRV
     IASNIAQLKV RAQQIADRRS RYGVNNPEHL DSSSSARTRA VNYEIAEYQV TSPQIIGIKE
     PVGMKTVMEE LEVWLTNPQA ENGQAVLSIV GFGGVGKTTI ATALYRKVSE KFQCRASVAV
     SQNYDQGKVL NSILSQVSNQ EQGSSTTISE KKNLTSGAKS MLKTALSLLR GNCICQPEND
     GNPDNTPIRL QETTDDDQNP RKLEQLLAEK SYILLIDDIW SAETWESIRS ILPKNNKGGR
     IIVTTRFQAV GSTCSPLETD RLHTVDFLTD DESQNLFNTS ICESKIRKDS NKVDEQVPEE
     IWKICGGLPL AIVSMAGLVA CNPRKACCDW SKLCKSLFPE QETPLTLDGV TRILDCCYND
     LPADLKTCLL YLSIFPKGWK ISRKRLSRRW IAEGFANEKQ GLTQERVAEA YFNQLTRRNL
     VRPMEHGSNG KVKTFQVHDM VLEYIMSKSI EENFITVVGG HWQMTAPSNK VRRLSMQSSG
     SNRGSSTKGL NLAQVRSLTV FGNLNHVPFH SFNYGIIQVL DLEDWKGLKE RHMTEICQML
     LLKYLSIRRT EISKIPSKIQ KLEYLETLDI RETYVRDLPK SIVQLKRIIS ILGGNKNTRK
     GLRLPQEKSK KPIKNPSPQG KTKEPAKKGF LSQEKGKGAM KALRVLSGIE IVEESSEVAA
     GLHQLTGLRK LAIYKLNITK GGDTFKQLQS SIEYLGSCGL QTLAINDENS EFINSLGDMP
     APPRYLVALE LSGKLEKLPK WITSITTLNK LTISVTVLRT ETLEILHILP SLFSLTFAFS
     LSAAKQDQDI IKDILENNKL DSDGEIVIPA EGFKSLKLLR FFAPLVPKLS FLDKNAMPAL
     EIIEMRFKDF EGLFGIEILE NLREVHLKVS DGAEAITKFL VNDLKVNTEK PKVFVDGIVT
     A